"Intraocular hemorrhage"

Massive intraocular hemorrhage, presumably from the central retinal artery after cataract surgery, and difficult hemostasis during vitrectomy: a case report. Severe intraocular hemorrhage is a rare complication of cataract surgery due to the recent generalization of minimal-incision cataract surgery. We report a case of a massive intraocular hemorrhage that probably originated from the central retinal artery after cataract surgery, in which hemostasis was difficult to achieve during vitrectomy. An 86-year-old woman was referred to our department for intraocular lens (IOL) dislocation after undergoing cataract surgery. Massive intraocular hemorrhage was observed during the initial visit to our department. She underwent pars plana vitrectomy (PPV) and IOL repositioning under local anesthesia

Association of Novel Oral Antithrombotics With the Risk of Intraocular Bleeding. Novel oral anticoagulation and antiplatelet therapies have become a mainstay of treatment for thromboembolic disease. However, the safety profile of these medications has not been completely characterized. To determine the risk of developing intraocular hemorrhages with novel oral antithrombotic therapy compared compared with those with new use of clopidogrel bisulfate. Both analyses required the patient to be in the insurance plan for at least 24 months prior to initiation of therapy and excluded patients with any previous diagnosis of intraocular hemorrhages or any prescription for the comparator medications. Furthermore, the antiplatelet analysis required a diagnosis of acute coronary syndrome or a myocardial

Intraocular Hemorrhages and Retinopathy of Prematurity in the Telemedicine Approaches to Evaluating Acute-Phase Retinopathy of Prematurity Study. To describe the clinical characteristics of intraocular hemorrhages (IOHs) in infants in the Telemedicine Approaches to Evaluating Acute-Phase Retinopathy of Prematurity (e-ROP) Study and to evaluate their potential use for prediction of disease

Combined Acute Haemolytic and Secondary Angle Closure Glaucoma following Spontaneous Intraocular Haemorrhages in a Patient on Warfarin To report the first described case of combined haemolytic and acute angle closure glaucoma secondary to spontaneous intraocular haemorrhages in a patient on excessive anticoagulation. To the best of our knowledge, this is the first case reported in the literature international normalised ratio (INR) was 7.7. B-scan ultrasound of posterior segment showed vitreous and suprachoroidal haemorrhages. An ultrabiomicroscopic examination confirmed open angles. A diagnosis of haemolytic glaucoma secondary to intraocular haemorrhages was made. The IOP was controlled medically. Warfarin was withdrawn and oral vitamin K therapy was initiated leading to a rapid INR reduction. Three

Risk of intraocular hemorrhage with new oral anticoagulants PurposeTo assess the risk of intraocular hemorrhage with warfarin and new oral anticoagulants (NOACs).MethodsWe ascertained all reported cases of intraocular hemorrhage (vitreous, choroidal, or retinal) with warfarin and NOACs (including dabigatran, rivaroxaban, apixaban) from the World Health Organizations's Vigibase database from 1968 -2015. We used a disproportionality analysis to compute reported odds ratios (RORs) and corresponding 95% confidence by comparing the number of events with the study outcomes and study drugs compared with all other drugs reported to Vigibase. A harmful signal was deemed for a lower limit of the 95% confidence interval above 1.ResultsWe identified 80 cases of intraocular hemorrhage (vitreous, choroidal

Intraocular hemorrhage causes retinal vascular dysfunction via plasma kallikrein. Retinal hemorrhages occur in a variety of sight-threatening conditions including ocular trauma, high altitude retinopathy, and chronic diseases such as diabetic and hypertensive retinopathies. The goal of this study is to investigate the effects of blood in the vitreous on retinal vascular function in rats . Intravitreal injections of exogenous PK induced retinal vascular permeability, leukostasis, and retinal hemorrhage. Proteomic analyses showed that PK increased collagen degradation in pericyte-conditioned medium and purified type IV collagen. Intravitreal injection of collagenase mimicked PK's effect on retinal hemorrhage. Intraocular hemorrhage increases retinal vascular permeability and leukostasis

for the gastrointestinal cohort and the ICH cohort but not for the 'other major bleeds' cohort (pericardial, retroperitoneal, intraspinal and intraocular bleeds), where the 30-day mortality was higher. The committee understood that important prognostic factors such as severity and volume of the bleed could not be included as covariates, because these were not collected in ORANGE. It also noted that 30-day mortality of patients for bleeds classified as 'other major bleeds' (pericardial, retroperitoneal, intraspinal and intraocular bleeds). The analysis results for these bleeds did not favour andexanet alfa compared with established clinical management with PCC, so the company considered it was counterintuitive and several assumptions were made to model these bleeds. The company assumed that andexanet alfa would lead

a sensitivity of 75% and a specificity of 94% of intraocular haemorrhage in AHT. Bilateral retinal haemorrhages are commonly reported. RHs are often too numerous to count and extend from posterior pole to ora serrata. RHs may be unilateral and asymmetrical but they are often reported as severe, multi-layered, and bilateral.3. Are any ocular fundus findings pathognomonic of child abuse? There are no fundus bilateral in cases of abusive head trauma, cases with unilateral haemorrhages do occur. They also occur in accidental head trauma, and in other pathologies. When they occur in association with unilateral intracranial haemorrhage, they are often but not exclusively ipsilateral.5. Can intraocular haemorrhage increase after injury? The area of retinal haemorrhage can increase in about one third of cases

23 3.2 Clinical features and pathology 24 3.2.1 Age of child at presentation 24 3.2.2 Characteristics of retinal findings 24 3.2.2.1 Site of retinal haemorrhages 24 3.2.2.2 Ocular fundus findings 25 3.2.2.3 Unilateral retinal haemorrhages 26 3.2.2.4 Frequency of intraocular haemorrhages 27 3.2.2.5 Timing of retinal haemorrhages 28 3.2.2.6 Intracranial findings or encephalopathy 29 bleeding? (abuse excluded)4. Which features or characteristics of non-vitreoretinal eye injury are present in child maltreatment, neglect and fabricated or induced illness?(i) What are the non-vitreoretinal ocular and ocular adnexal injuries seen in (a) Abuse (b) Fabricated or induced injury and (c) Neglect?5. Can retinal haemorrhages be dated? (i) Can intraocular haemorrhages increase after injury

within 1 to 5 minutes (thunderclap headache) and lasts more than an hour; typically alongside vomiting, photophobia, and non-focal neurological signs.Examination may be normal or may reveal altered consciousness, meningismus, ocular findings (e.g., intraocular haemorrhages), or focal findings (e.g., unilateral loss of motor function, loss of visual field, aphasia).Order an urgent non-contrast computed

that can lead to permanent loss of vision (< 1.1%2) High intraocular pressure Decrease in vision, severe pain Intraocular bleeding Numerous floaters Toxic anterior segment syndrome

of retinal detachment, intraocular bleeding, and complications associated with the anesthesia-induced hypotension used to decrease the risk of bleeding. Either adjuvant brachytherapy or neoadjuvant proton-beam therapy are administered. Experience is limited to retrospective, single-center, case series.[10-12][Level of evidence C3]Surgical resection of metastasesSurgical resection of metastases from ocular

bleed’) and the ICH plus GI cohort. In the whole cohort, the submitting company assumed ‘other major bleeds’ included intraocular bleeds, intraspinal bleeds, pericardial bleeds and retroperitoneal bleeds. The economic analysis was based on a model comprising a short-term decision tree followed by a long-term Markov model. The decision tree estimates costs and QALYs for the first 30 days of the bleeding event; defined as either an ICH, severe GI bleed, intraocular bleed, intraspinal bleed, pericardial bleed or retroperitoneal bleed. Patients who survive transition to their respective survivor health states in the Markov model and remain in their respective health states until death. A cycle length of 1 month was implemented in the Markov model with a half cycle correction applied

malfunctioning, requiring removal and replacement. They considered that the following were theoretical adverse events: intraocular haemorrhage, glaucoma, photopsia, choroidal neovascularisation, thermal injury to neurons, choroidal or retinal circulation abnormalities, and complications associated with vitrectomy. 6 6 Committee comments Committee comments 6.1 The Committee noted that insertion of a subretinal

2022SummarySubarachnoid haemorrhage (SAH) presents as a sudden, severe headache that peaks within 1 to 5 minutes (thunderclap headache) and lasts more than an hour; typically alongside vomiting, photophobia, and non-focal neurological signs.Examination may be normal or may reveal altered consciousness, meningismus, ocular findings (e.g., intraocular haemorrhages), or focal findings (e.g., unilateral loss of motor

2022SummarySubarachnoid haemorrhage (SAH) presents as a sudden, severe headache that peaks within 1 to 5 minutes (thunderclap headache) and lasts more than an hour; typically alongside vomiting, photophobia, and non-focal neurological signs.Examination may be normal or may reveal altered consciousness, meningismus, ocular findings (e.g., intraocular haemorrhages), or focal findings (e.g., unilateral loss of motor

and intraocular hemorrhage. Poor vision in both eyes was noted after the patient regained consciousness. B-scan ultrasonography showed extensive vitreous opacity with a posterior vitreous detachment and without obvious retinal detachment. Vitrectomy was performed in both eyes five months after the accident. After clearing up the vitreous opacity, a peculiar pigmented mushroom-like mass lesion was noted