Symptom-based Kikuchidisease subtypes: Clinical scenarios across specialties in Taiwan with temporal trends analysis. We propose a subtyping system for Kikuchidisease based on chief complaints and fever status. A chart review of 388 patients diagnosed with Kikuchidisease. The subtypes afebrile lymphadenopathy (aLAP), febrile lymphadenopathy (FebLAP), and febrile accounted for 68 %, 18 longer periods. Approximately 9 % of patients were referred to rheumatology; these patients more frequently used disease-modifying antirheumatic drugs and steroids and were followed for an extended duration. From 2005 to 2022, the incidence of Kikuchidisease has doubled, driven by otolaryngologists' aggressive use of ultrasound-guided core needle biopsy to diagnose more aLAP cases. Patients
Kikuchidisease in acute leukaemia: a distinct clinical syndrome with HLA association. To report the clinicopathological features of Kikuchidisease in patients with acute leukaemia, emphasising similarities among cases. In a cohort of 454 Kikuchidisease patients, we identified three cases of concurrent acute leukaemia. These patients shared similar clinical traits, with Kikuchidisease emerging approximately a month after induction chemotherapy onset, featuring neck-region lymphadenopathy. Notably, two patients were middle-aged, deviating from the typical age distribution of Kikuchidisease. Histologically, these cases aligned with typical Kikuchidisease. Negative immunohistochemical stains (CD34, CD117, ERG, TdT) indicated the absence of extramedullary leukaemic infiltration. Herpes
A patient with P369S/R408Q variants in the MEFV gene presented with clinical features of Kikuchidisease and Mollaret meningitis, successfully treated with colchicine. This case report presents the case of a patient with P369S and R408Q variants in the MEFV gene who exhibited clinical features of Kikuchidisease and Mollaret meningitis. Furthermore, it discusses colchicine as a new potential treatment option for Kikuchidisease-associated meningitis. A 41-year-old Japanese woman presented with fever and headache. She had nuchal rigidity and bilateral cervical lymphadenopathies. Her past medical history included multiple episodes of aseptic meningitis and cervical lymphadenopathy for more than twenty years. Lumbar puncture showed increased lymphocytes and IL-6 level and pathognomonic Mollaret
KikuchiDisease in Children: Case Report and Review of the Literature. Kikuchidisease (KD) is a rare and generally benign condition of uncertain etiology that presents with nonspecific symptoms including fever and cervical lymphadenopathy. Clinical presentations can vary. Here, we present an atypical case of KD in a 10-year-old girl, as well as an updated literature review of the clinical presentation, laboratory features and management of KD in children. Studies (published up until February 2020) were identified through searches of PubMed using the following search items: Kikuchi-Fujimoto disease or histiocytic necrotizing lymphadenitis or Kikuchidisease. Our primary search resulted in 1117 publications. A total of 34 publications with a total of 670 patients were included in the final
KikuchiDisease with an Exuberant Proliferation of Large T cells: A Study of 25 Cases that Can Mimic T-Cell Lymphoma. Exuberant large T-cell proliferations in Kikuchidisease potentially can be misdiagnosed as lymphoma. In this study, we explore their clinicopathological features and summarize key points that can be used to distinguish them from T-cell lymphoma. The cohort consists of 25 cases of Kikuchidisease with an exuberant large T cell proliferation which, in part, mimicked lymphoma. The median age was 25 years with a female:male ratio of 4:1. The patients presented with either isolated lymphadenopathy (60%) involving the cervical and axillary regions or generalized lymphadenopathy (40%). Histologically, lymph nodes showed paracortical and interfollicular expansion by sheets of large
Distribution of lymphadenopathy in patients with Kikuchidisease. Cervical lymphadenopathy is among the cardinal manifestations of Kikuchidisease (KD). The incidences and locations of extra-cervical lymph nodes (LNs) involvement in KD have not been comprehensively reported. From 2003 to 2016, 60 patients with pathologically confirmed KD and with computed tomography and/or whole-body
Association Kikuchidisease with Hashimoto thyroiditis: a case report and literature review Kikuchi-Fujimoto disease (KFD) is a benign and self-limited disease characterized by fever and lymphadenopathy. The etiology of KFD is unknown, but an autoimmune cause has been suggested. Hashimoto thyroiditis is the most common autoimmune thyroid disorder in children and is known to be associated
Expanding the clinical spectrum of self-limiting, rare Kikuchidisease - A case with overwhelming multi-organ involvement. Kikuchidisease is a rare disorder with an unknown pathogenesis and a typically self-limiting natural course in predominantly previously healthy young women. Here we present a 54-year-old woman suffering from an overwhelming presentation of Kikuchidisease, associated with haemophagocytic syndrome, liver cell necrosis and nephrotic syndrome. She recovered fully without immunosuppressive treatment. This case report adds to the already broad clinical spectrum of Kikuchidisease described in literature. Awareness among physicians of the full clinical spectrum of Kikuchidisease and the self-limiting nature of this syndrome leads to a good diagnostic approach and may prevent
Recurrent Kikuchi'sDisease Treated by Hydroxychloroquine Kikuchi-Fujimoto disease (KFD) is a benign, self-limiting disease, with a specific histopathology. It can be diagnosed clinically, and specific symptoms include fever and cervical lymphadenopathy. The histological finding of KFD in cervical lymph nodes includes necrotizing lymphadenitis. KFD needs conservative treatments. If KFD persists
KikuchiDisease with Generalized Lymph Node, Spleen and Subcutaneous Involvement Detected by Fluorine-18-Fluorodeoxyglucose Positron Emission Tomography/Computed Tomography Kikuchi-Fujimoto disease, known as Kikuchidisease, is a rare benign and self-limiting disorder that typically affects the regional cervical lymph nodes. Generalized lymphadenopathy and extranodal involvement are rare. We
KikuchiDisease-Like Inflammatory Pattern in Cutaneous Inflammatory Infiltrates Without Lymph Node Involvement: A New Clue for the Diagnosis of Lupus? Kikuchi-Fujimoto disease (KFD) is a rare and benign disorder that usually occurs in young adults with enlarged lymph nodes containing infiltrate of cytotoxic T cells and nuclear debris. It can be a manifestation of systemic lupus erythematosus (SLE called these skin lesions "Kikuchidisease-like inflammatory pattern" (KLIP). Twenty-nine patients, whose median age was 49 years at the time of skin biopsy, were selected and retrospectively analyzed using standardized clinical and histology charts. In skin biopsies, KLIP was localized to restricted areas within the inflammatory infiltrate (17%) or diffuse (83%), and was the only histological finding
Comparison of Ultrasonographic Findings of Biopsy-Proven Tuberculous Lymphadenitis and KikuchiDisease Although tuberculous lymphadenitis and Kikuchidisease are common causes of cervical lymphadenopathy in Asians and exhibit similar clinical manifestations, their treatment strategies are totally different. The purpose of this study was to identify ultrasonographic features that distinguish these two diseases. This study was approved by the Institutional Review Board. The study included 77 patients with tuberculous lymphadenitis and 135 patients with Kikuchidisease. The sex and age distributions of the patients were analyzed. The size and shape of lymph nodes (LNs), presence of conglomeration, increased perinodal echogenicity, echogenic hilum, posterior neck involvement, internal
Kikuchidisease presenting with aseptic meningitis. Kikuchidisease is a self-limited disease characterized primarily by regional lymphadenopathy. Kikuchidisease was first described in 1972 as a lymphadenitis with specific histopathologic findings. Extranodal manifestations have been reported, including rare neurologic complications such as aseptic meningitis. This case report discusses a patient who presented to the ED with signs and symptoms suggestive of aseptic meningitis and was ultimately diagnosed with Kikuchidisease. We also review the epidemiology, clinical presentation, and laboratory findings typically found in patients with Kikuchidisease. Inclusion of Kikuchidisease in the differential diagnosis for meningitis may help establish a diagnosis in patients also presenting