"Kveim test"

Diagnostic yield of the Kveim test in sarcoidosis patients. Sarcoidosis is a granulomatous disorder of unknown etiology characterized by the existence of non-caseating granulomatous inflammation. Diagnosis can be challenging due to the presence of comprehensive clinical, laboratory, and radiologic manifestations. We have evaluated the diagnostic yield of the Kveim test and compared this test with the other conventional laboratory modalities. Our aim was to reach the highest level of diagnostic confidence acknowledging the absolute uncertainty in diagnosis with the current diagnostic enterprises. Medical records of 300 sarcoidosis patients were reviewed. Patients were classified into two categories as the conventional laboratory and the Kveim test group to compare the diagnostic yield. Sensitivity

idiopathic sarcoidosis is the level of immunoglobulins, which is increased in persons with sarcoidosis and decreased in those with CVID. The Kveim test is not helpful because it returns a positive finding in up to 40-50% of CVID patients. Serum angiotensin-converting enzyme (ACE) levels, a marker of macrophage activity, are elevated in approximately a third of these patients. In vitro T-cell

develop sarcoidal granulomas. [14, 15, 16, 17] Previous Next: Kveim-Siltzbach Test and Tuberculin Skin TestKveim-Siltzbach testThe Kveim test is the most specific test for sarcoidosis. It is not commonly available, nor commonly used, because of difficulty in obtaining a validated antigen source, as well as a fear of transmitting infection. The Kveim test involves intradermal injection of tissue from

develop sarcoidal granulomas. [14, 15, 16, 17] Previous Next: Kveim-Siltzbach Test and Tuberculin Skin TestKveim-Siltzbach testThe Kveim test is the most specific test for sarcoidosis. It is not commonly available, nor commonly used, because of difficulty in obtaining a validated antigen source, as well as a fear of transmitting infection. The Kveim test involves intradermal injection of tissue from

develop sarcoidal granulomas. [14, 15, 16, 17] Previous Next: Kveim-Siltzbach Test and Tuberculin Skin TestKveim-Siltzbach testThe Kveim test is the most specific test for sarcoidosis. It is not commonly available, nor commonly used, because of difficulty in obtaining a validated antigen source, as well as a fear of transmitting infection. The Kveim test involves intradermal injection of tissue from

idiopathic sarcoidosis is the level of immunoglobulins, which is increased in persons with sarcoidosis and decreased in those with CVID. The Kveim test is not helpful because it returns a positive finding in up to 40-50% of CVID patients. Serum angiotensin-converting enzyme (ACE) levels, a marker of macrophage activity, are elevated in approximately a third of these patients. In vitro T-cell

develop sarcoidal granulomas. [14, 15, 16, 17] Previous Next: Kveim-Siltzbach Test and Tuberculin Skin TestKveim-Siltzbach testThe Kveim test is the most specific test for sarcoidosis. It is not commonly available, nor commonly used, because of difficulty in obtaining a validated antigen source, as well as a fear of transmitting infection. The Kveim test involves intradermal injection of tissue from

, noncaseating granulomatous nodules. Scanning electron microscopy and energy-dispersive radiograph analysis revealed large quantities of silicates. Cellular immunologic studies showed normal response to beryllium, and results of Kveim testing were negative. We suspect that exposure to one or more materials resulting from the WTC catastrophe may be implicated in the development of granulomatous pulmonary

sites were correlated with demographic data, chest radiographic stages, symptoms, pulmonary function and associated organ involvement. Seven hundred and seventy-six diagnostic biopsies were performed. Five hundred and sixty-seven were intrathoracic, 198 extrathoracic. Eleven Kveim tests were positive. When cutaneous sarcoidosis or an enlarged extrathoracic lymph node was present, skin or lymph node Bx

* sarcoidosis * Kveim test * pulmonary embolism * Hampton hump * Westermark

* sarcoidosis * Kveim test * pulmonary embolism * Hampton hump * Westermark

the diagnosis more likely; elevations in angiotensin-converting enzyme and calcium in the blood, too, make sarcoidosis more likely. In the past, the Kveim test was used to diagnose sarcoidosis. This now obsolete test had a high (85 percent) sensitivity, but required spleen tissue of a known sarcoidosis patient, an extract of which was injected into the skin of a suspected case.[1]Only biopsy of suspicious

Observations on the Kveim reaction using an animal model of granulomatous bowel disease. Striking differences were observed between the visceral and cutaneous responses after tests with validated Kveim and normal spleen suspensions in a guinea pig model of granulomatous bowel disease. Five of six animals sensitised with BCG showed positive responses at the ileal Kveim test site whereas all six had negative cutaneous Kveim tests. Conversely, two of six animals sensitised with irradiated Mycobacterium leprae showed positive cutaneous Kveim tests and only one a positive response in the ascending colon. All six showed negative responses at the ileal Kveim test site. No positive visceral or cutaneous responses were observed in either group of animals after tests with normal spleen suspension

Chronic pulmonary sarcoidosis: relationship between lung lavage cell counts, chest radiograph, and results of standard lung function tests. Thirty three consecutive untreated patients with pulmonary sarcoidosis, confirmed histologically or by Kveim test, were investigated to correlate cell counts in bronchoalveolar lavage fluid with clinical features, the chest radiograph, and results of lung

of the bronchial mucosa in 17 out of 22 patients. Kveim tests were completed in 44 patients: results were positive in 19, equivocal in 11, and negative in 14. In 16 patients histological support was obtained on biopsy of various other tissues. The clinical presentation of the disease and the degree of histological support provided by the various procedures used in reaching a diagnosis of sarcoidosis varied

Pulmonary granulomatous reaction: talc pneumoconiosis or chronic sarcoidosis? A chronic pulmonary granulomatous reaction was associated with an almost identical clinical picture in two patients exposed to talc. In both patients lung biopsy showed the deposition of talc particles and a heavy granulomatous reaction. At the time of diagnosis the Kveim test result was negative in both patients

Kveim test.

Validation and standardization of Kveim test suspensions prepared from two human sarcoid spleens. Single lots of a Chase-Siltzbach type I Kveim test material from each of two sarcoid spleens and designated lot 5 of spleen K12 and lot 1 of spleen K13 have been validated alongside a single lot (lot 10) of a 'standard' suspension provided by Dr L. E. Siltzbach and prepared identically from and in healthy subjects. All patients were closely matched and two Kveim tests were made in each subject according to a prearranged statistical design. The reactivity of the K12, K12 1/2 dilution, and K13 suspensions among patients with active and inactive sarcoidosis was closely similar to that with the 'standard' S10 suspension and in accordance with the expected proportions of reactions in patients

The Kveim test.

`Residual bodies' in sarcoid and sarcoid-like granulomas A MORPHOLOGICAL AND HISTOCHEMICAL STUDY WAS MADE OF EPITHELIOID CELL GRANULOMAS: (a) classical sarcoid type, namely, sarcoidosis, Kveim tests, tuberculosis, farmer's lung, and Crohn's syndrome; (b) sarcoid-like granulomas, often distinguishable from (a) by the presence of extracellular mucin or bile, namely, ulcerative colitis