that mimic DS well. Here we explored the anti-epileptiform mechanisms of FA by investigating whether selective agonists/antagonists of specific receptor subtypes were able to counteract the FA-induced inhibition of seizures and abnormal brain discharges observed in the mutants. We show that antagonists of 5-HT and 5-HT receptor subtypes were able to do so (LY310762 and SB 242084, respectively