"Loperamide\/simethicone"

without loperamide (C) to improve clinical diarrhea, fecal frequency, and time to diarrhea resolution?Qualitative AnalysisThere were a total of 10 RCTs[4–10][15–17] that described 2,325 patients, including 819 patients who received loperamide. Loperamide was compared with placebo,[4][5][15–17] a combination of loperamide-simethicone,[4][5] simethicone alone,[4][5]Saccharomyces boulardii,[6] bismuth and simethicone alone.[4][5] Loperamide was found to be more effective when compared with simethicone alone, but loperamide-simethicone was more beneficial than loperamide in terms of fecal frequency, time to diarrhea resolution, and overall improvement diarrhea-related symptoms.Two studies evaluated performance of loperamide compared with diphenoxylate/atropine.[8][9] Both studies showed a positive effect

,fecal frequency, and time to diarrhea resolution?QUALITATIVE ANALYSISThere were a total of 10 RCTs4–10,15–17that described2,325 patients, including 819 patients who received loperamide.Loperamide was compared with placebo,4,5,15–17a combinationof loperamide-simethicone,4,5simethicone alone,4,5Saccharomycesboulardii,6bismuth subsalicylate,7diphenoxylate/atropine,8,9andwood creosote.10The effect of loperamidewith simethicone and simethicone alone.4,5Loperamide wasFigure 1.PRISMA flow diagram for study selection.JTraumaAcuteCareSurgVolume87,Number4Bugaev et al.© 2019 Wolters Kluwer Health, Inc. All rights reserved.917Copyright © 2019 Wolters Kluwer Health, Inc. All rights reserved.found to be more effective when compared with simethiconealone, but loperamide-simethicone was more beneficial thanloperamide

Randomized, double-blind, placebo-controlled clinical trial of loperamide plus simethicone versus loperamide alone and simethicone alone in the treatment of acute diarrhea with gas-related abdominal discomfort. To compare efficacy and tolerability of a loperamide/simethicone (LOP/SIM) combination product with that of loperamide (LOP) alone, simethicone (SIM) alone, and placebo (PBO) for acute

Loperamide-simethicone vs loperamide alone, simethicone alone, and placebo in the treatment of acute diarrhea with gas-related abdominal discomfort. A randomized controlled trial. Acute diarrhea with gas-related abdominal discomfort is a common, usually self-limited disorder with substantial social and economic impact. To compare the efficacy and safety of a loperamide hydrochloride-simethicone -related abdominal discomfort were the protocol-specified primary outcomes. Secondary outcomes included time to complete relief of diarrhea, number of unformed stools, and patient-assessed variables at the end of the study (overall illness relief, diarrhea relief, and abdominal discomfort relief). Patients who received loperamide-simethicone had significantly (P < .001) shorter time to last unformed

A scintigraphic study to investigate the potential for altered gut distribution of loperamide from a loperamide-simethicone formulation in man. A loperamide simethicone combination formulation has recently been demonstrated to have significant clinical advantages compared to loperamide alone in the relief of diarrhoea and related symptoms. The product visualisation technique of gamma scintigraphy

) * Difenoxin * does not cross BBB: Eluxadoline * Loperamide# (+simethicone) Intestinal anti-inflammatory agents

hour study, subjects will rate the overall effectiveness of the product.Condition or disease Intervention/treatment Phase Diarrhea Drug: loperamide-simethicone Drug: matching placebo Phase 4 Detailed Description: A six-hour study to evaluate multiple early efficacy endpoints in loperamide-simethicone therapy to help identify speed of Multiple Endpoints in Measuring the Onset of Clinical Efficacy of Loperamide-Simethicone Caplets in the Treatment of Acute Non-specific Diarrhea Study Start Date : October 2008

. Evaluation of simethicone for the treatment of postoperative abdominal discomfort in infants. J Clin Anesth. 1998 Mar;10(2):91-4. Kaplan MA, Prior MJ, Ash RR, McKonly KI, Helzner EC, Nelson EB. Loperamide-simethicone vs loperamide alone, simethicone alone, and placebo in the treatment of acute diarrhea with gas-related abdominal discomfort. A randomized controlled trial. Arch Fam Med. 1999 May-Jun;8(3):243

More InformationGo to Top of Page Study Description Study Design Arms and Interventions Outcome Measures Eligibility Criteria Contacts and Locations More Information Publications automatically indexed to this study by ClinicalTrials.gov Identifier (NCT Number): Cottrell J, Koenig K, Perfekt R, Hofmann R; Loperamide-Simethicone Acute Diarrhoea Study Team. Comparison of Two Forms of Loperamide