Successful management of lymphangiosarcoma in a puppy using a tyrosine kinase inhibitor A puppy was diagnosed with lymphangiosarcoma associated with lymphedema based on lymphography and histopathology. The lesions resolved after toceranib therapy, and the dog remains in remission 1 year later. This is the first report of a successful outcome following oral toceranib as first-line therapy for lymphangiosarcoma in a dog.
Lymphangiosarcoma with bone formation of the auricle in a dog A 12-year-old mixed-breed neutered female dog was referred with cutaneous tumors at the left auricle. Histologically, the cutaneous tumor located in the dermis comprised numerous clefts and cavernous channels lined by neoplastic endothelial cells with no erythrocytes. Bone tissue without direct contact with neoplastic cells was seen membrane beneath the tumor cells. Histopathological features of this case were consistent with lymphangiosarcoma, and stromal ossification was characteristic.
Constitutive Activation of mTORC1 in Endothelial Cells Leads to the Development and Progression of Lymphangiosarcoma through VEGF Autocrine Signaling Angiosarcoma/lymphangiosarcoma is a rare malignancy with poor prognosis. We generated a mouse model with inducible endothelial-cell-specific deletion of Tsc1 to examine mTORC1 signaling in lymphangiosarcoma. Tsc1 loss increased retinal angiogenesis in neonates and led to endothelial proliferative lesions from vascular malformations to vascular tumors in adult mice. Sustained mTORC1 signaling was required for lymphangiosarcoma development and maintenance. Increased VEGF expression in tumor cells was seen, and blocking autocrine VEGF signaling abolished vascular tumor development and growth. We also found significant correlations between mTORC1
Lymphangiosarcoma with systemic metastases in a Japanese domestic cat A 4-year-2-month-old female Japanese domestic cat was diagnosed with lymphangiosarcoma through tissue biopsy of an amputated leg. Two months later, the cat was euthanized, and postmortem findings revealed edema, and bruising at the caudal region of the trunk, pulmonary hemorrhage, pulmonary nodules and mediastinal for vimentin, von Willebrand factor and CD31. Based on the histopathological and immunohistochemical features, the neoplasia was diagnosed as lymphangiosarcoma with systemic metastases.
with activities of daily living (ADL).Grade 4: Progression to malignancy (e.g., lymphangiosarcoma); amputation indicated; disabling lymphedema.The fifth version of the CTCAE is more streamlined and does not include limb volumes:[28]Grade 1: Trace thickening or faint discoloration.Grade 2: Marked discoloration; leathery skin texture; papillary formation; limitation in instrumental ADL.Grade 3: Severe symptoms
the following:[4-6]Previous radiation therapy.Chronic lymphedema (risk factor for lymphangiosarcoma).Exposure to the chemicals thorium dioxide (Thorotrast), vinyl chloride, or arsenic. These are established carcinogens for hepatic angiosarcomas.HIV and human herpesvirus 8 infection. These viruses have been implicated in the pathogenesis of Kaposi sarcoma. For more information, see Kaposi Sarcoma
Establishment and characterization of a novel lymphangiosarcoma cell line (MO-LAS) compared with the hemangiosarcoma cell line (ISO-HAS) The concept of "lymphangiosarcoma" remains obscure. Therefore, we reported a patient with lymphangiosarcoma, resistant to immunotherapy. The patient presented with impressive and discriminative features: clinically an ill-defined edematous lesion with lymphorrhea and pathologically atypical vascular channel formation without extravasation of blood, clearly distinguished from common angiosarcoma with hemorrhage. From this case, a lymphangiosarcoma cell line, MO-LAS, was established and its characteristics were compared with the hemangiosarcoma cell line, ISO-HAS. Flow cytometric analysis revealed that MO-LAS was negative for factor VIII-related antigen
created a new mouse model for human lymphangiosarcoma by deleting Tsc1 in endothelial cells and consequent hyper-activation of mTORC1. Using Tsc1 tumour cells from this mouse model, we assessed the efficacies of histone deacetylase (HDAC) inhibitors as anti-tumour agents for mTORC1-driven tumours. Unlike the cytostatic effect of mTORC1 inhibitors, HDAC inhibitors induced Tsc1 tumour cell death in vitro observed increased reactive oxygen species and endoplasmic reticulum stress in SAHA-treated tumour cells, suggesting their contribution to autophagic cell death, which were dependent on mTORC1 hyper-activation. These studies suggest a potential new treatment strategy for mTORC1-driven cancers like lymphangiosarcoma through an alternative mechanism.
changes may suggest a superficial haemangioma, lymphangiosarcoma, dermatofibrosarcoma or Kaposi's sarcoma.NB: a patient with a sudden increase in size of lump, change in consistency, increased pain and/or neurovascular compromise are all red flags that indicate a need for an urgent specialist assessment[2].Differential diagnosisDVT.Vascular masses - popliteal artery aneurysm, cystic adventitial degeneration of popliteal artery (Erdheim's mucoid degeneration), haemangioma.Inflammatory arthritides.Septic arthritis.Postoperative changes (seroma, haematoma, abscess).Haemophilic arthropathy.Benign soft tissue tumour - peripheral nerve sheath tumours (neurolemmoma).Malignant - myxoid liposarcoma (adults), lipoblastoma (children, especially aged <5 years), lymphangiosarcoma, dermatofibrosarcoma, Kaposi's
in lymphangioma circumscriptum is vital, as recurrence following surgical resection and secondary development of lymphangiosarcoma and squamous cell carcinoma following treatment with radiation have been reported. Thus, it is important to consider lymphangioma circumscriptum in the differential of similar lesions in the future to allow appropriate diagnosis, treatment, and monitoring.
patient exhibited STS type 2 [mixed lymphangiosarcoma (mLAS)]. The MRI signal intensity (SI) of all the nodules was compared with the pathological results. In the T1WI sequences, all nodules showed isointensity compared with normal muscle tissues in the same image. However, in the T2WI sequences, there were the visually recognizable differences in the SI compared with the LE tissues in the two STS types
) The vast majority of SAS occurs in the radiation field following radiation therapy for breast cancer, called radiation angiosarcoma of the breast (RAAS). 2) Chronic lymphedema following breast surgery and lymphatic drainage, which may also be referred to as Stewart-Treves syndrome or lymphangiosarcoma. Due to the rarity of the disease and the difficulty of diagnosis, there is no standard therapy
lymphangiosarcomas. Other malignancies associated with Maffucci syndrome include pancreatic and hepatic adenocarcinoma, ovarian tumors, brain gliomas, astrocytomas, and other types of sarcomas. [6] Previous Next: EpidemiologyMaffucci syndrome is rare. Fewer than 100 cases of Maffucci syndrome have been reported in the United States with about 160 total case reports in the English literature. No increased frequency
for lymphangiosarcoma (Stewart-Treves syndrome), which is an aggressive tumor with a dismal prognosis. Cutaneous angiosarcoma has also been reported in massive localized lymphedema in morbidly obese patients. [17] Previous Next: Patient EducationPatients should be reassured. Lymphangiectases pose no potential for malignant transformation.For patient education resources, see the Women's Health Center and Cancer
superinfection of ruptured vesicles, cleansing the affected area daily with topical antibacterial agents and applying mupirocin ointment or silver sulfadiazine cream are advisable.Follow-up care is essential for early treatment of lymphangiectasia recurrences. Lymphangiosarcoma (Stewart-Treves syndrome) may occur in chronic edematous limbs, and early detection is critical. At times, severe recurrent cellulitis