MALTlymphoma Skip to main contentSkip to searchLog inEnglish#{autosuggest.search}#{autosuggest.search}MALTlymphoma MENULog in or subscribe to access all of BMJ Best PracticeLast reviewed:10 Dec 2023Last updated:05 Jan 2024SummaryMucosa-associated lymphoid tissue (MALT) lymphoma is categorised as indolent or low-grade B-cell lymphoma; however, high-grade histological transformation can occur.Median age at presentation is approximately 60 years.The stomach is the most frequently involved organ, and in most cases (90%), there is a strong association between gastric MALTlymphoma and chronic Helicobacter pylori infection.Other sites that may be involved include the ocular adnexa, lung, parotid gland, skin, intestinal tract, and thyroid. May also occur (rarely) in breasts, dura
CT radiomics analysis discriminates pulmonary lesions in patients with pulmonary MALTlymphoma and non-pulmonary MALTlymphoma. The aim of this study is to create and validate a radiomics model based on CT scans, enabling the distinction between pulmonary mucosa-associated lymphoid tissue (MALT) lymphoma and other pulmonary lesion causes. Patients diagnosed with primary pulmonary MALTlymphoma and lung infections at Fuzhou Pulmonary Hospital were randomly assigned to either a training group or a validation group. Meanwhile, individuals diagnosed with primary pulmonary MALTlymphoma and lung infections at Fujian Provincial Cancer Hospital were chosen as the external test group. We employed ITK-SNAP software for delineating the Region of Interest (ROI) within the images. Subsequently, we
Response-adapted ultra-low-dose 4 Gy radiation as definitive therapy of gastric MALTlymphoma: a single-centre, pilot trial. Given the favourable prognosis of patients with gastric mucosa-associated lymphoid tissue (MALT) lymphoma, treatment-related toxicity should be minimised. We aimed to evaluate the efficacy of 4 Gy radiotherapy given in a response-adapted approach. We conducted a single -centre, single-arm, prospective trial at MD Anderson Cancer Center (Houston, TX, USA) of response-adapted ultra-low-dose radiotherapy. Eligible patients were 18 years or older and had newly diagnosed or relapsed Helicobacter pylori-negative gastric MALTlymphoma, with stage I-IV disease. Given the expected low toxicity profile of treatment, performance status was not an exclusion criterion. Patients
Primary lymphoma of mucosa associated lymphoid tissue (MALTlymphoma) in the urinary bladder mimicking recurrent urinary tract infection: a case report and literature review. We report the case of a 79-year-old woman with primary lymphoma of mucosa-associated lymphoid tissue (MALT) in the urinary bladder. The patient, with urinary frequency, urgency and suprapubic pain had several emergency room visits due to recurrent urinary tract infection. Both sonogram and cystoscopy identified bladder tumors near the bladder neck. An abdominal contrast-enhanced computed tomography scan revealed a polypoid lesion on the anterior bladder wall without enlarged lymph nodes. Transurethral resection of the bladder tumor was conducted. The pathology report confirmed extranodal marginal zone MALTlymphoma
Endoscopic morphology of gastric MALTlymphoma correlate with API2/MALT1 fusion and predict treatment response after helicobacter pylori eradication. The presence of API2/MALT1 fusion in gastric mucosa-associated lymphoid tissue (MALT) lymphoma predicts poor response to Helicobacter pylori (Hp) eradication therapy. This study aimed to assess the correlation between endoscopic morphology of MALTlymphoma and API2/MALT1 fusion and evaluate treatment response to Hp eradication based on morphological subtypes. A retrospective review was conducted on patients diagnosed with gastric MALTlymphoma between January 2011 and December 2022. Endoscopic morphology was categorized as superficial, non-superficial, or mixed type. The superficial type was further classified into gastritis superficial lesion
Safety and efficacy of intralesional rituximab injection versus involved site radiation therapy in primary ocular adnexal MALTlymphoma: study protocol for a multicentre randomised controlled trial. Involved site radiation therapy (ISRT) is a widely used treatment for primary ocular adnexal mucosa-associated lymphoid tissue (MALT) lymphoma with control rates over 85%; however, its complications could reach 30%-50%. Intralesional rituximab injection has shown promising results with remission rates between 65% and 100% and minimal complications. This study aimed to conduct a multicentre randomised controlled clinical trial to compare the safety and efficacy of intralesional rituximab injection versus ISRT on primary ocular adnexal MALTlymphoma. This is a multicentre randomised controlled
MALTlymphomaMALTlymphoma - Symptoms, diagnosis and treatment | BMJ Best PracticeSkip to main contentSkip to search * About us * Help * Subscribe * Access through your institution * Log inBMJ Best Practice * Help * Getting started * FAQs * Contact us * Recent updates * Specialties * Calculators * Patient leaflets * Videos * Evidence * Drugs * Recent updates * Specialties * Resources * Guidelines * Images and videos * References * Patient leaflets * Evidence Log in or subscribe to access all of BMJ Best PracticeLast reviewed: 13 Jun 2022Last updated: 30 Mar 2021SummaryMucosa-associated lymphoid tissue (MALT) lymphoma is categorised as indolent or low-grade B-cell lymphoma; however, high-grade histological
The Distinctive Nature of Thyroid MALTLymphomas Including IRTA1 Expression. Mucosa-associated lymphoid tissue (MALT) lymphomas often express IgM and IRTA1 with only a minority demonstrating plasmacytic differentiation. However, like primary cutaneous marginal zone lymphoproliferative disorders (PCMZLPD), thyroid MALTlymphomas (T-MALT-L) frequently show plasmacytic differentiation and IgG , and sometimes in germinal centers. IRTA1 positivity was also present in all HT cases, although it was never very extensive and often had a perifollicular distribution, occasionally with sparse aggregates and positive cells within rare thyroid follicles. Thus, T-MALT-L share some features with PCMZLPD but are more similar to noncutaneous MALTlymphomas, with prominent lymphoepithelial lesions, ubiquitous
Radiomics analysis of T1WI and T2WI magnetic resonance images to differentiate between IgG4-related ophthalmic disease and orbital MALTlymphoma. Preoperative differentiation between IgG4-related orbital disease (IgG4-ROD) and orbital mucosa-associated lymphoid tissue (MALT) lymphoma has a significant impact on clinical decision-making. Our research aims to construct and evaluate a magnetic resonance imaging (MRI)-based radiomics model to assist clinicians to better identify IgG4-ROD and orbital MALTlymphoma and make better preoperative medical decisions. MR images and clinical data from 20 IgG4-ROD patients and 30 orbital MALTlymphoma patients were classified into a training (21 MALT; 14 IgG4-ROD) or validation set (nine MALT; six IgG4-ROD). Radiomics features were collected from T1
GPR34 activation potentially bridges lymphoepithelial lesions to genesis of salivary gland MALTlymphoma. GPR34 translocation and mutation are specifically associated with salivary gland MALTlymphoma (SG-MALT-lymphoma). The majority of GPR34 mutations are clustered in its C-terminus, resulting in truncated proteins lacking the phosphorylation motif important for receptor desensitization . It is unclear why GPR34 genetic changes associate with SG-MALT-lymphoma and how these mutations contribute to the development of lymphoma. We generated isogenic Flp-InTRex293 cell lines that stably expressed a single copy of GPR34 or its various mutants and performed a range of in vitro assays. We found that the GPR34 Q340X truncation, but not the R84H and D151A mutants, conferred a significantly increased
Thyroid MALTlymphoma: self-harm to gain potential T-cell help. The development of extranodal marginal zone lymphoma of mucosa-associated lymphoid tissue (MALT) is driven by chronic inflammatory responses and acquired genetic changes. To investigate its genetic bases, we performed targeted sequencing of 93 genes in 131 MALTlymphomas including 76 from the thyroid. We found frequent deleterious mutations of TET2 (86%), CD274 (53%), TNFRSF14 (53%), and TNFAIP3 (30%) in thyroid MALTlymphoma. CD274 was also frequently deleted, together with mutation seen in 68% of cases. There was a significant association between CD274 mutation/deletion and TNFRSF14 mutation (p = 0.001). CD274 (PD-L1) and TNFRSF14 are ligands for the co-inhibitory receptor PD1 and BTLA on T-helper cells, respectively
Involvement of non-Helicobacter pylori helicobacter infections in Helicobacter pylori-negative gastric MALTlymphoma pathogenesis and efficacy of eradication therapy. Eradication therapy is known to be effective against Helicobacter pylori-positive gastric MALTlymphoma but predicting the efficacy of eradication therapy against Helicobacter pylori-negative gastric MALTlymphoma is difficult . Recent reports have shown that non-Helicobacter pylori helicobacter infections induce gastric MALTlymphoma, and we aimed to clarify whether non-Helicobacter pylori helicobacter infections are associated with the efficacy of eradication therapy. We analyzed eradication therapy as a first-line treatment for 182 cases of gastric MALTlymphoma, classified according to Helicobacter pylori infection
Dieulafoy disease with gastric MALTlymphoma: A case report. Dieulafoy lesion (DL), a rare cause of gastrointestinal bleeding, is easily covered by blood scab formation on the mucous membrane for its small size, which makes it difficult to be identified under endoscope. In clinical practice, it is also very easy to miss gastric mucosa-associated lymphoid tissue (MALT) lymphoma that exhibits
MALTlymphoma of the colon: a clinicopathological review. Extranodal marginal zone lymphoma of mucosa-associated lymphoid tissue (MALTlymphoma) occurs in approximately 9% of non-Hodgkin B cell lymphoma. However, it occurs only rarely within the colon. The presentation is often asymptomatic, and can have multiple endoscopic appearances, including a single or multinodular polypoid lesion studied. Therefore, an updated review on MALTlymphoma of the colon is needed.
Unique expansion of IL-21+ Tfh and Tph cells under control of ICOS identifies Sjögren's syndrome with ectopic germinal centres and MALTlymphoma. To explore the relevance of T-follicular-helper (Tfh) and pathogenic peripheral-helper T-cells (Tph) in promoting ectopic lymphoid structures (ELS) and B-cell mucosa-associated lymphoid tissue (MALT) lymphomas (MALT-L) in Sjögren's syndrome (SS
Mucosa-associated Lymphoid Tissue (MALT) Lymphoma We value your privacyWe and our partners store and/or access information on a device, such as cookies and process personal data, such as unique identifiers and standard information sent by a device for personalised ads and content, ad and content measurement, and audience insights, as well as to develop and improve products. With your permission GI tract, ocular adnexa, salivary gland, thyroid, lung, thymus and breast.Splenic.MALT lymphomas can be divided into:Gastric: the most common type and associated with H. pylori infection.Non-gastric: most often in the head and neck, lung and eye. Non-gastric MALTlymphomas are not associated with H. pylori infection.AetiologyMALT can develop in nearly every organ as a result of chronic infection
Outcomes After Reduced-Dose Intensity Modulated Radiation Therapy for Gastric Mucosa- Associated Lymphoid Tissue (MALT) Lymphoma. In patients with gastric extranodal marginal zone lymphoma of mucosa-associated lymphoid tissue (MALT) lymphoma, the standard radiation therapy (RT) dose is ≥30 Gy. We report the outcome of patients treated with reduced dose 24 Gy compared with those treated with ≥30 Gy. We reviewed results from 32 patients who received a diagnosis of gastric MALTlymphoma between 2007 and 2017 who were treated with involved site RT using intensity modulated radiation therapy (IMRT). Response to therapy was based on post-RT endoscopic biopsy. Freedom from local treatment failure (FFLTF), freedom from treatment failure (FFTF), and overall survival (OS) outcomes were determined