How I treat microangiopathichemolyticanemia in patients with cancer. Microangiopathichemolyticanemia (MAHA) with thrombocytopenia, suggests a thrombotic microangiopathy (TMA), linked with thrombus formation affecting small or larger vessels. In cancer patients, it may be directly related to the underlying malignancy (initial presentation or progressive disease), to its treatment
MicroangiopathicHemolyticAnemia in Pregnancy. Thrombotic microangiopathies (TMAs) are associated with microangiopathichemolyticanemia and thrombocytopenia, resulting in microvascular thrombosis and end-organ damage. In pregnancy, this may be the result of pregnancy-related TMAs such as preeclampsia; hemolysis, elevated liver enzymes, and low platelets; or pregnancy-associated TMAs
Acute Hepatitis Caused by Genotype 4 HCV Presenting with MicroangiopathicHemolyticAnemia Many cases have been reported about the role of chronic hepatitis C and interferon therapy in the development and recurrence of thrombotic thrombocytopenic purpura (TTP), but to our knowledge there is no previous report about the association between acute hepatitis C and any microangiopathichemolyticanemia (MAHA) including TTP. We report a case of acute hepatitis C that presented with MAHA resembling TTP, which resolved with spontaneous clearance of viral infection.
R Inguinal/R Scrotum Extramammary Paget's Disease with Diffuse Spine Metastasis Complicated by MicroangiopathicHemolyticAnemia A 47-year-old male presented with a groin lesion in 2011. Initial treatment with antifungals and vinegar was unsuccessful. In 2016, biopsy of this lesion was pursued with diagnosis of extramammary Paget's disease (EMPD). Prior to the scheduled excision, he developed constant lower back pain with radiation to his lower extremities. MRI confirmed vertebral metastasis. Despite surgical and radiation therapy, his back pain progressed, and repeat imaging showed epidural spread of tumor in the thoracic spine. Later, the patient was admitted to the hospital due to severe anemia and thrombocytopenia. Further work-up confirmed the diagnosis of microangiopathichemolytic
MicroangiopathicHemolyticAnemia Due to ADAMTS-13 Loss in Idiopathic Systemic Capillary Leak Syndrome. Essentials Idiopathic systemic capillary leak syndrome (SCLS) is characterized by episodes of vascular leakage. We present the case of a patient with SCLS who developed microangiopathichemolyticanemia (MAHA). We propose that this anemia is the result of ADAMTS-13 loss in the third-space fluid
MicroangiopathicHemolyticAnemia Due to Malignancy in Pregnancy. Microangiopathic disorders during pregnancy remain a diagnostic challenge because these conditions often imitate more common obstetric diseases. A 31-year-old multigravid woman delivered at term with a postpartum course complicated by laboratory indices consistent with hemolysis, elevated liver enzymes, and low platelet count syndrome. After clinical recovery, she was readmitted 2 weeks after delivery with presumptive pyelonephritis. Persistent hemolysis and worsening thrombocytopenia suggested a diagnosis of thrombotic microangiopathy, which did not respond to plasma exchange. Directed bone biopsy revealed metastatic signet ring cell adenocarcinoma. Microangiopathichemolyticanemia is rarely the initial clinical
A Case of MicroangiopathicHemolyticAnemia after Myxoma Excision and Mitral Valve Repair Presenting as Hemolytic Uremic Syndrome Microangiopathichemolyticanemia occurs in a diverse group of disorders, including thrombotic thrombocytopenic purpura, hemolytic uremic syndrome, and prosthetic cardiac valves. Hemolytic anemia also occurs as a rare complication after mitral valve repair . In this report, we describe a case of microangiopathichemolyticanemia following myxoma excision and mitral valve repair, which was presented as hemolytic uremic syndrome.
A rare case of concurrent signet-ring carcinoma of breast and microangiopathichemolyticanemiaMicroangiopathichemolyticanemia (MAHA) can be an uncommon presentation of an underlying malignancy, most often due to signet-ring cell carcinoma (SRCC). Additionally, pure SRCC in a breast primary-tumor comprises <2% of all breast cancers (Shin SY, Park H, Chae SW, Woo HY. Microangiopathichemolyticanemia as the first manifestation of metastatic signet-ring cell carcinoma of unknown origin: a case report and review of literature. Kor J Lab Med 2011;31:157-61). To the best of our knowledge, the combination of these two entities, pure breast primary SRCC along with MAHA, has not been reported. Here, we present such a rare case. We also evaluate the current literature regarding this and similar
Microangiopathichemolyticanemia associated with metastatic breast cancer: case report and literature review Microangiopathichemolyticanemia (MAHA) is a mechanical hemolytic anemia characterized by the emergence of fragmented red cells in peripheral blood. Here, we report a case of breast cancer associated with cancer-related (CR)-MAHA along with a literature review. The patient was a 54-year
Signet Ring Cell Carcinoma Presenting with MicroangiopathicHemolyticAnemia: A Systematic Review Signet Ring Cell Carcinoma Presenting with MicroangiopathicHemolyticAnemia: A Systematic Review Print | PDF PROSPERO This information has been provided by the named contact for this review. CRD has accepted this information in good faith and registered the review in PROSPERO. The registrant
Evaluation of patients with microangiopathichemolyticanemia and thrombocytopenia. When a patient presents with unexpected microangiopathichemolyticanemia and thrombocytopenia, the diagnosis of thrombotic thrombocytopenic purpura (TTP) is often considered. However, many different disorders, including many different systemic infections and malignancies, can cause thrombotic microangiopathy (TMA ), with the clinical features of microangiopathichemolyticanemia and thrombocytopenia. Other etiologies include severe hypertension, preeclampsia, systemic lupus erythematosus, adverse drug reactions, allogeneic hematopoietic stem cell transplantation, and abnormalities of complement regulation. This article focuses on distinguishing TTP from other etiologies of microangiopathichemolyticanemia
Relapsing catastrophic antiphospholipid syndrome potential role of microangiopathichemolyticanemia in disease relapses. To analyze the clinical and laboratory characteristics of patients with catastrophic antiphospholipid syndrome (APS) who suffer relapses. We analyzed the Web site--based international registry of patients with catastrophic APS ("CAPS Registry") http://infmed.fcrb.es/es/web were not fully described. Therefore, a total of 18 episodes were analyzed. In 9 (50%) episodes, a precipitating factor was identified. The most frequent precipitating factor, found in 5 (28%) episodes, was infection. Brain, kidney, heart, and lung were the most common organs involved. Laboratory features of microangiopathichemolyticanemia (MHA) were present in 13 of 18 (72%) episodes (definitive
Cancer-related microangiopathichemolyticanemia: clinical and laboratory features in 168 reported cases. Cancer-related microangiopathichemolyticanemia (CR-MAHA) is a paraneoplastic syndrome characterized by Coombs-negative hemolytic anemia with schistocytes and thrombocytopenia. We reviewed and analyzed all cases of CR-MAHA reported since 1979 (the time of the last published review
MicroangiopathicHemolyticAnemia in 57-year-old Woman with Borderline Serous Tumor of the Ovary: Real-Time Management of Common Pathways of Hemostatic Failure