Intranasal Nafarelin For Triggering Oocyte Maturation This is a non-inferiority randomised, controlled clinical trial comparing subcutaneous triptorelin to intranasal nafarelin for the final maturation of oocytes in oocyte donors undergoing ovarian stimulation. Oocyte donors meeting the inclusion criteria will be randomised to receive triggering for final oocyte maturation with 200 micrograms of subcutaneous triptorelin (control group) or 800 micrograms of intranasal nafarelin (experimental group). The primary outcome is the number of mature (metaphase 2 (MII)) oocytes collected. The study has been designed with a non-inferiority limit of a difference of 2 mature oocytes, with 80% power and one-sided alpha of 0.05.
are candidates for treatment with dienogest b Dienogestc 2 Symptomatic treatment of adult women of reproductive age with endometriosis who have already been treated with medication or surgery and who are no (longer) candidates for treatment with dienogestb GnRH analogues (goserelin or buserelin or leuprorelin or triptorelin or nafarelin)c a. Presented is the respective ACT specified by the G-BA. b with dienogest b Dienogestc Added benefit not proven 2 Symptomatic treatment of adult women of reproductive age with endometriosis who have already been treated with medication or surgery and who are no (longer) candidates for treatment with dienogestb GnRH analogues (goserelin or buserelin or leuprorelin or triptorelin or nafarelin)c Added benefit not proven a. Presented is the respective ACT specified
deficiency. J Clin Endocrinol Metab 75 (4): 1022-6, 1992. [PUBMED Abstract]Isaacs JT: Hormonal balance and the risk of prostatic cancer. J Cell Biochem Suppl 16H: 107-8, 1992. [PUBMED Abstract]Peters CA, Walsh PC: The effect of nafarelin acetate, a luteinizing-hormone-releasing hormone agonist, on benign prostatic hyperplasia. N Engl J Med 317 (10): 599-604, 1987. [PUBMED Abstract]Kyprianou N, Isaacs JT
. Private fertility clinic. Forty-six high-responder patients were administered a GnRHa ovulation trigger to avoid ovarian hyperstimulation syndrome (OHSS), followed by 2 weeks of daily intranasal GnRHa (nafarelin) for luteal-phase support. No additional progesterone supplementation was administrated. Intranasal GnRHa for luteal-phase support. The primary outcome was ongoing clinical pregnancy rate. High
normal 4. Management 1. Counseling and reassurance 2. Consider GnRH analog to suppress FSH and LH 1. Leuprolide (Lupron) long acting injectable 2. Nafarelin (Synarel) short acting intranasal XII. Evaluation: Step 2b - Normal Variation in Step 1 1. Findings 1. Early, but normal Puberty 2. Bone Age consistent with Chronological age
and diabetes. [16] GnRH agonists approved in the United States include leuprolide (Eligard, Lupron, Viadur), nafarelin (Synarel), triptorelin (Trelstar), histrelin (Vantas), and goserelin (Zoladex). Nafarelin is approved only for the management of endometriosis; all others are approved for the treatment of advanced prostate cancer.Previous Next: Selection of Candidates for NADTHigh-risk patients (ie, those
warnings describing the increased risk for heart disease and diabetes. [30] The following GnRH agonists are approved in the United States: * * Leuprolide (Eligard, Lupron, Viadur) * * Nafarelin (Synarel) * * Triptorelin (Trelstar) * * Histrelin (Vantas) * * Goserelin (Zoladex). Intermittent androgen therapyIntermittent androgen suppression is a well-established treatment offered to patients