Cocaine-Like Discriminative Stimulus Effects of Mephedrone and Naphyrone in Mice In recent years, commercial products containing synthetic cathinone analogues have emerged as illicit drugs of abuse. These cathinones are structurally similar to the psychostimulants 3,4-methylenedioxymethamphetamine (MDMA) and methamphetamine (METH), and produce their effects via interactions with monoamine transporters, where smaller compounds (e.g., mephedrone) are amphetamine-like monoamine releasers, while the structurally larger compounds (e.g., naphyrone) are cocaine-like monoamine reuptake inhibitors. Individual cathinones also differ from one another with respect to selectivity among the three monoamine transporters. This study was designed to assess the cocaine-like interoceptive effects of synthetic
-butyrophenone) * * Butylone (beta-keto-N-methyl-3,4-benzodioxyolybutanamine) * * Methedrone (4-methoxymethcathinone) * * Pentedrone (α-methylaminovalerophenone) * * Naphyrone (naphthylpyrovalerone) The many different sympathomimetic agents produce their physiologic and toxicologic properties through several different mechanisms. Nevertheless, toxicity from these agents typically presents similarly
-butyrophenone) * * Butylone (beta-keto-N-methyl-3,4-benzodioxyolybutanamine) * * Methedrone (4-methoxymethcathinone) * * Pentedrone (α-methylaminovalerophenone) * * Naphyrone (naphthylpyrovalerone) The many different sympathomimetic agents produce their physiologic and toxicologic properties through several different mechanisms. Nevertheless, toxicity from these agents typically presents similarly