Optic neuritis Skip to main contentSkip to searchEnglish (US)EnglishPortuguês中文Log inSearchSearchHomeOptic neuritis MENULog in or subscribe to access all of BMJ Best PracticeLast reviewed:28 May 2024Last updated:06 Jun 2024Summary Optic neuritis (ON) may involve the retrobulbar (retrobulbar neuritis) or the intrabulbar (papillitis) portion of the optic nerve, or both. Idiopathic ON, the most
Ultrasound pupillometry for the detection of a relative afferent pupillary defect (RAPD): Systematic evaluation in patients with optic neuritis and comparison with infrared video pupillometry. A relative afferent pupillary defect (RAPD) is a characteristic clinical sign of optic neuritis (ON). Here, we systematically evaluated ultrasound pupillometry (UP) for the detection of an RAPD in patients
Association of relapses with visual outcomes in optic neuritis: a post hoc analysis of the Optic Neuritis Treatment Trial. To examine whether the number of relapses is associated with visual outcomes in patients with optic neuritis. A post hoc analysis using data from the Optic Neuritis Treatment Trial, a multicenter randomized controlled trial conducted to explore the efficacy of corticosteroids on optic neuritis. Multivariate linear mixed effect models were used to estimate the associations of the number of ipsilateral relapses in the baseline affected eye with visual outcomes. The modeling accounted for the number of ipsilateral relapses and adjusted for time to follow-up visit, baseline visual function, treatment groups, the number of contralateral relapses, the interaction between
Predictive model for converting optic neuritis to multiple sclerosis; decision tree in focus. Optic neuritis (ON) can be an initial clinical presentation of multiple sclerosis This study aims to provide a practical predictive model for identifying at-risk ON patients in developing MS. We utilized data from the Optic Neuritis Treatment Trial study, which enrolled 457 patients aged from 18 to 46
Visual Outcomes Following Plasma Exchange for Optic Neuritis: An International Multicenter Retrospective Analysis of 395 Optic Neuritis Attacks. To evaluate the effectiveness of plasma exchange (PLEX) for optic neuritis (ON). We conducted an international multicenter retrospective study evaluating the outcomes of ON following PLEX. Outcomes were compared to raw data from the Optic Neuritis
Herpes zoster ophthalmicus with acute retrobulbar optic neuritis and abducens nerve palsy: a case report. Herpes zoster Ophthalmicus (HZO) affecting the ophthalmic division (V1) of the trigeminal nerve. HZO may cause extraocular muscle palsies, with the third nerve being the most commonly affected and the fourth nerve the least. The combined involvement of the optic nerve and isolated paralysis
RENEWED: A follow-up study of the opicinumab phase 2 RENEW study in participants with acute optic neuritis. The randomized, phase 2 RENEW trial (NCT01721161) evaluated efficacy/safety of opicinumab (anti-LINGO-1) versus placebo in patients with first-episode unilateral acute optic neuritis (AON). Although no significant differences in the latency recovery of visual evoked potential (VEP) were
Clinical predictors in acute optic neuritis: Analysis based on clinical trial data. To identify baseline clinical predictors of visual outcomes six months after acute optic neuritis using data from our completed clinical neuroprotection trial (TONE study). Secondary analysis of data from the TONE study cohort (NCT01962571). Total of 103 patients presenting within 10 days of a first episode of acute unilateral optic neuritis as a clinically isolated syndrome with baseline high contrast visual acuity (HCVA) < 20/40 Snellen (logMAR 0.3). Patients were recruited from 12 German university hospitals between November 25, 2014, and October 9th, 2017. We selected potential predictors based on literature research and experience, then computed initial linear regression models that each included one
Vestibular Function in Patients With Vestibular Neuritis Experiencing Prodromal Dizziness. It is unknown whether prodromal dizziness (PD) before an attack of vestibular neuritis (VN) has an association with peripheral vestibular lesions. The purpose of this study was to investigate whether the severity of vestibular dysfunction has an association with the presence of PD. We reviewed the medical
Optic neuritis, as unusual manifestations of hypoparathyroidism: a rare case report. Optic neuritis, commonly associated with multiple sclerosis (MS), can also occur in the context of hypocalcemia as a rare intriguing clinical scenario. Most recent articles have reported the association of papilledema and hypoparathyroidism, However, very rarely, case reports revealed hypocalcemia-induced optic neuritis as well as our case. We report a 43-year-old woman with a history of hypocalcemia presenting with optic neuritis, characterized by sudden vision loss, painful eye movements, and pulsatile headache. Despite the normalization of serum calcium level and pulses of steroid treatment for the most probable underlying cause (demyelination); visual acuity improvement was not regained. Lumbar puncture
Case report: Coexistence of optic neuritis and primary anti-PLA2R-positive membranous nephropathy. Optic neuritis (ON) is an inflammatory optic neuropathy characterized by acute vision loss. Primary anti-PLA2R-positive membranous nephropathy, an autoimmune disease, has been reported to be related to neurological diseases. However, the co-occurrence of ON and primary membranous nephropathy (PMN
Effectiveness of oral prednisone tapering following intravenous methylprednisolone for acute optic neuritis in multiple sclerosis. Acute optic neuritis treatment lacks standardized protocols. The value of oral prednisone taper (OPT) following intravenous methylprednisolone (IVMP) on visual outcome parameters in optic neuritis (ON) has never been explored. In the present retrospective study, we
Peripapillary choroidal microvasculature dropout is associated with poor prognosis in optic neuritis. To identify peripapillary choroidal microvasculature dropout (MvD) in eyes with optic neuritis and its association with longitudinal changes in retinal nerve fiber layer (RNFL) and ganglion cell-inner plexiform layer (GCIP) thicknesses following diagnosis. A total of 48 eyes with optic neuritis (41.7%) with optic neuritis. MvD was most commonly found in the temporal quadrant (85.0%), and peripapillary retinal vessel density in the temporal quadrant was significantly lower in eyes with MvD (P = 0.012). At 6 months follow-up, optic neuritis eyes with MvD showed significantly thinner GCIP in superior, superotemporal, inferior and inferotemporal sectors (P<0.05). No significant difference
Trends in Plasma Exchange Utilization in Optic Neuritis Hospitalizations in the United States. To report utilization trends of plasma exchange (PLEX) as well as sociodemographic and medical comorbidities associated with PLEX in the United States (US). Retrospective cross-sectional study. Adult patients (≥18 years old) admitted for inpatient hospitalization with a primary diagnosis of optic neuritis (ON). Data from the National Inpatient Sample database was compiled to assess PLEX utilization rates between the year 2000 through 2020. The cohorts of patients receiving PLEX versus no PLEX were analyzed between quarter four of 2015 through 2020 (ICD-10 only) for patient sociodemographic variables, medical diagnoses, insurance types, hospital characteristics, etiology of disease, time
Myelin oligodendrocyte glycoprotein (MOG) associated optic neuritis in a patient with idiopathic intracranial hypertension (IIH) and compressive optic neuropathy case report. Myelin oligodendrocyte glycoprotein-associated disease (MOGAD) has a wide phenotypic expression and should be considered in a differential diagnosis of patients with optic disc edema and increased intracranial pressure
Prognostic factors of first-onset optic neuritis based on diagnostic criteria and antibody status: a multicentre analysis of 427 eyes. Optic neuritis (ON) prognosis is influenced by various factors including attack severity, underlying aetiologies, treatments and consequences of previous episodes. This study, conducted on a large cohort of first ON episodes, aimed to identify unique prognostic
The risk of optic neuritis following mRNA COVID-19 vaccination compared to COVID-19 infection and other vaccinations. to determine the risk of optic neuritis (ON) after mRNA COVID-19 vaccine administration. U.S. National aggregate database retrospective cohort study SUBJECTS: Patients were placed into cohorts based on mRNA COVID-19 vaccination status (no vaccine and positive history of COVID-19 ratio (RR) of optic neuritis 21 days after vaccination (or COVID-19 infection) and incidence of ON per 100,000 individuals. After matching, the first dose COVID-19 and influenza vaccine cohorts (n=1,678,598, mean age [standard deviation] at vaccination of 45.5[23.3] and 43.2[25.5], 55% female) had a 0.44 risk reduction of developing ON (95% CI 0.28-0.80). The first dose COVID-19 and Tdap (n=797,538
Pearls & Oy-sters: Optic Neuritis as First Demyelinating Event During Pregnancy in 2 Young Hispanic Women: MS vs MOGAD. Optic neuritis (ON) can present as the first demyelinating attack in both multiple sclerosis (MS) and myelin oligodendrocyte glycoprotein (MOG) antibody-associated disease (MOGAD), which may require different treatment depending on the final diagnosis. We present 2 young
Radiological predictors of visual outcome in myelin oligodendrocyte glycoprotein-related optic neuritis. This study aimed to determine whether magnetic resonance imaging (MRI) biomarkers are associated with visual prognosis in myelin oligodendrocyte protein (MOG)-associated optic neuritis (MOG-ON). Cross-sectional analysis. Patients meeting 2023 international diagnostic criteria for MOG antibody