Intralesional Injections of a TNF-α Inhibitor to Treat OrofacialGranulomatosis. We present the first documented case of successful treatment of orofacialgranulomatosis by intralesional injections of a tumor necrosis factor α inhibitor to the lip. Our patient had rapid symptomatic improvement after 3 injections, and near resolution within 4 months of anti-tumor necrosis factor α therapy.
Disease-related burden and long-term outcome in orofacialgranulomatosis: observations from a large single-centre cohort. There is a lack of standardized treatment recommendations for orofacialgranulomatosis, a chronic inflammatory condition aetiologically related to Crohn disease. To assess clinical baseline parameters and treatment strategies, we retrospectively analysed 61 consecutive cases
OrofacialGranulomatosis Associated with Crohn's Disease: a Multicentre Case Series. Orofacialgranulomatosis [OFG] is a rare syndrome that may be associated with Crohn's disease [CD]. We aimed to characterise this relationship and the management options in the biologic era. This multicentre case series was supported by the European Crohn's and Colitis Organisation [ECCO], and performed as part
Streptococcus Salivarius: A Potential Salivary Biomarker for OrofacialGranulomatosis and Crohn's Disease? Orofacialgranulomatosis (OFG) is a rare disease characterised by chronic, noncaseating, granulomatous inflammation primarily affecting the oral cavity. Histologically, it is similar to Crohn's disease (CD), and a proportion of patients have both OFG and CD. The cause of OFG remains elusive
Detailed Follow-up Study of Pediatric OrofacialGranulomatosis Patients. Orofacialgranulomatosis (OFG) is a chronic inflammatory condition affecting the orofacial area. Its connection to Crohn disease (CD) is debated. Our aim was to describe a cohort of pediatric patients with OFG in detail, study the long-term behavior of OFG, and evaluate factors predicting CD in patients with OFG. We invited
Effectiveness of surgical treatment of severe macrocheilia in a patient with orofacialgranulomatosis. Orofacialgranulomatosis (OFG) is the term given to a group of diseases characterized by the presence of non-necrotizing granulomatous inflammation affecting the soft tissues of the orofacial region. Treatment of OFG is often challenging and unsatisfactory. We report on a 32-year-old man
Orofacialgranulomatosis: A case report of three cases may be caused by apical periodontitis. Orofacialgranulomatosis (OFG) is a rare disease characterized by noncaseating granulomatous inflammation. The most common clinical presentation is persistent swelling of the soft tissues in the oral and maxillofacial regions. The precise cause of OFG is unknown. Corticosteroids are the first-line
Treatment of orofacialgranulomatosis: a case report Orofacialgranulomatosis is a relatively recent term coined by Wiesenfield et al. in 1985 to define granulomatous lesions of oral mucosa without intestinal involvement. When it presents in a triad encompassing facial nerve palsy, lip swelling, and fissured or furrowed tongue it is called Melkersson-Rosenthal syndrome while monosymptomatic or oligosymptomatic forms are referred to as granulomatous cheilitis. It is an uncommon clinicopathologic entity which is distinct from classic Crohn's disease. The NOD2 variant which is commonly associated with Crohn's has not been shown to have any association with orofacialgranulomatosis. We present a case of a 31-year-old white man who had painful swelling of the lip with oral ulcers and difficulty eating
Does Crohn's Disease with Concomitant OrofacialGranulomatosis Represent a Distinctive Disease Subtype? Although orofacialgranulomatosis (OFG) may present as a separate clinical entity, it often seems in conjunction with various systemic diseases, of which Crohn's disease (CD) is one of the most common. The aim of this study was to investigate whether CD with concomitant OFG represents
Genetic Association Analysis Reveals Differences in the Contribution of NOD2 Variants to the Clinical Phenotypes of OrofacialGranulomatosis. Orofacialgranulomatosis (OFG) is a rare, inflammatory disorder of the mouth, in which some patients also have intestinal Crohn's disease (CD). The etiology remains largely unknown, although there is a high prevalence of atopy, and oral granulomas are also
Uncommon inflammatory swelling of the lips: orofacialgranulomatosisOrofacialgranulomatosis (OFG) is an unusual condition associated with permanent or recurrent swelling of orofacial tissues together with oral mucosal ulceration and a variety of orofacial characteristics. The chronic inflammation inherent to OFG often displays granulomas in the subepithelial stroma. We present a case of OFG
Adverse reaction to silicone simulating orofacialgranulomatosis. Granulomatous reactions to silicone facial fillers are well described in the literature. Clinically, these reactions present as nodules or pseudotumors that are frequently described as silicone granulomas or siliconomas. We want to report a peculiar form of granulomatous reaction to injected silicone characterized by recurrent describe and illustrate a new type of adverse reaction to injected silicone simulating orofacialgranulomatosis. The reaction presents as recurrent, unilateral, asymmetric facial edema of the cheek in patients who have been injected with silicone in the face. Familiarity with this adverse reaction will help to prevent erroneous diagnoses such as idiopathic angioedema, Melkersson Rosenthal syndrome
OrofacialGranulomatosis in Children can be the Initial Manifestation of Systemic Disease: A Presentation of Two Cases Orofacialgranulomatosis is a chronic granulomatous condition characterized by relapsing and remitting lip swelling and oral involvement that may include deep ulcers, tags and cobblestone formation. It occurs as an independent entity but also in conjunction with systemic diseases such as tuberculosis, sarcoidosis and Crohn's disease. The clinical presentation is not indicative of concomitant systemic disease. To highlight the importance of thorough examination to rule out systemic disease, we present two childhood cases of orofacialgranulomatosis, one of which was associated to Crohn's disease.