*" or "Non-steroidal anti-inflammator*" or "Nordihydroguaiaretic Acid" or NSAID* or osenal or Oxametacin or Oxaprozin or Oxyphenbutazone or Parecoxib or "Pentosan Sulfuric Polyester" or Phenazone or Phenylbutazone or Piroxicam or Pirprofen or Prenazone or Proglumetacin or Rofecoxib or Salicylamide or Salicylate or Sulfasalazine or Sulfinpyrazone or Sulindac or Suprofen or Tenoxicam or "Tiaprofenic acid
[Pharmacokinetics of oxametacin in healthy volunteers following multiple administration (author's transl)]. In a double-blind cross-over study 2 groups of 6 healthy volunteers were dosed with 2 x 75 mg and 3 x 75 mg/d oxametacin (1-p-chlorobenzoyl-2-methyl-5-methoxy-3-indolylacethydroxamic acid). Plasma concentrations of oxametacin and indometacin metabolites were compared. 6 volunteers received 2 x 75 mg oxametacin/d for the first 5 d. Thereafter a drug-free period (1 week) followed and finally they received 3 x 75 mg drug/d a further 5 d. The second group of 6 was dosed identically in the reverse order. Plasma concentrations of oxametacin metabolites were significantly higher after the 3 x 75 mg daily dose than after the 2 x 75 mg dose. The steady-state level for both doses was reached