"Oxytocin"

Managing risks associated with oxytocin infusions during labour Managing risks associated with oxytocin infusions during labour – SPS - Specialist Pharmacy Service – The first stop for professional medicines advice SPS - Specialist Pharmacy Service The first stop for professional medicines advice * About * Log in * Register NHS * Guidance Guidance * Guidance index * COVID-19 vaccines * PGDs medicines * Homecare * ATMPs * Clinical Trials * Medical gases * Record keeping * More * Less * Home * Guidance * Medication Safety Managing risks associated with oxytocin infusions during labour Published 24 September 2024 Topics: Medication Safety · Oxytocin Safety strategies can minimise the risk of harms related to oxytocin infusion overdose and delayed therapy. Contents 1. Patient harm 2. Clinical

The Oxytocin System and Implications for Oxytocin Deficiency in Hypothalamic-Pituitary Disease. Oxytocin is a hypothalamic-posterior pituitary hormone with multiple effects, ranging from regulation of energy homeostasis to bone health and psychological wellbeing, in addition to its well-known effects in labor and lactation. Patients with hypothalamic and pituitary damage have a higher risk for medical and psychiatric comorbidities despite standard-of-care hormone replacement, and a clinically relevant oxytocin deficient state has been identified in patients with arginine vasopressin deficiency (formerly known as central diabetes insipidus) in the last decade. Therefore, oxytocin deficiency in patients with hypothalamic and pituitary damage is an emerging field. While intranasal oxytocin

Intranasal oxytocin increases breast milk oxytocin, but has a reduced effect in depressed mothers: A randomized controlled trialcon. Oxytocin (OT) plays pivotal roles in stress regulation, mother-infant bonding, and breastfeeding, all of which are adversely impacted by postnatal depression (PND). In a double-blind, randomized controlled trial, we assessed endogenous OT concentrations first

Oxytocin with calcium vs. oxytocin for induction of labor in women with term premature rupture of membranes: A randomized controlled trial: Oxytocin with calcium gluconate for labor induction. Intravenous calcium administration has shown promise in enhancing uterine contractions and reducing blood loss during cesarean section, but this regimen has not been compared in vaginal labor induction . To determine the efficacy of oxytocin combined with calcium versus oxytocin alone for inducing labor among women with term premature rupture of membranes (PROM). This single-blind, randomized control trial was conducted between October 2022 and May 2023 in a tertiary university hospital. Patients diagnosed with PROM were randomly allocated into two groups. The intervention group received a bolus of 10 mL

Uterogenic Agents (Misoprostol versus to Oxytocin) for Postpartum Hemorrhage HomeReviewsTherapy (NNT) ReviewsDiagnosis (LR) ReviewsAboutThe NNT, ExplainedThe NNT Rating SystemtheNNT Editorial ProcessThe NNT Intervention QuizAbout theNNT TeamSubmit an articleAccountLoginSign upContactDONATEUterogenic Agents (Misoprostol versus to Oxytocin) for Postpartum HemorrhageNot more effective than oxytocin after birth. Uterine atony is the most common cause of PPH,3 and oxytocin is recommended as first-line medical therapy by the American College of Obstetricians and Gynecologists and the World Health Organization.3, 4 However, there are many effective (i.e. better than placebo) ‘uterotonic’ agents for the treatment of PPH,1 including misoprostol which may be used alone or in combination with oxytocin

Two oxytocin analogs, N-(p-fluorobenzyl) glycine and N-(3-hydroxypropyl) glycine, induce uterine contractions ex vivo in ways that differ from that of oxytocin. Contraction of the uterus is critical for parturient processes. Insufficient uterine tone, resulting in atony, can potentiate postpartum hemorrhage; thus, it is a major risk factor and is the main cause of maternity-related deaths worldwide. Oxytocin (OT) is recommended for use in combination with other uterotonics for cases of refractory uterine atony. However, as the effect of OT dose on uterine contraction and control of blood loss during cesarean delivery for labor arrest are highly associated with side effects, small amounts of uterotonics may be used to elicit rapid and superior uterine contraction. We have previously

Oxytocin versus carbetocin at elective Cesarean delivery in parturients with class III obesity: a double-blind randomized controlled noninferiority trial Class III obesity (body mass index [BMI] ≥ 40 kg·m) is associated with high rates of Cesarean deliveries and postpartum hemorrhage, with increased maternal and fetal morbidity. The doses of oxytocin and carbetocin are two to four times higher at Cesarean delivery in patients with class III obesity. We sought to investigate the efficacy of carbetocin 80 µg iv compared with oxytocin 1 IU iv (plus infusion) at elective Cesarean delivery in parturients with class III obesity. We hypothesized that, with equipotent dosing, carbetocin would be noninferior to oxytocin. We conducted a randomized, double-blind, noninferiority study in nonlabouring, term

Age-dependent effects of oxytocin in brain regions enriched with oxytocin receptors. Although intranasal oxytocin administration to tap into central functions is the most commonly used non-invasive means for exploring oxytocin's role in human cognition and behavior, the way by which intranasal oxytocin acts on the brain is not yet fully understood. Recent research suggests that brain regions densely populated with oxytocin receptors may play a central role in intranasal oxytocin's action mechanisms in the brain. In particular, intranasal oxytocin may act directly on (subcortical) regions rich in oxytocin receptors via binding to these receptors while only indirectly affecting other (cortical) regions via their neural connections to oxytocin receptor-enriched regions. Aligned

Statement of retraction: a prospective randomised trial comparing Foley catheter, oxytocin, and combination Foley catheter-oxytocin for labour induction with unfavourable cervix.

A Comparative Study of the Efficacy of Intraoperative Intravenous Oxytocin and Intramuscular Oxytocin Versus Conventional Intramuscular Oxytocin for Third-Stage Labour in Elective Cesarean Section. Objective  To study the efficacy of intraoperative IV oxytocin and intramuscular (IM) oxytocin versus conventional intramuscular oxytocin alone for active management of the third stage of labor in lower segment cesarean section (CS). The study was performed to determine the effect of 5 IU (International Unit) oxytocin infusion at the time of skin incision and that of 10 IU IM oxytocin infusion after delivery in reducing blood loss during and after CS, in comparison with the effect of administrating conventional 10 IU IM oxytocin in the same time period. In addition, it assessed the ability

Validation of two immunoassays for oxytocin measurements in human saliva. The objective of this research was to develop and validate two immunoassays for oxytocin measurement in human saliva, one using a monoclonal and the other a polyclonal antibody against oxytocin, whose affinity for oxytocin was tested by an antibody mapping epitope analysis. These assays were analytically validated and used to compare oxytocin concentrations with those obtained with a commercial kit before and after the extraction or reduction/alkylation (R/A) treatments to saliva samples. The assays were also used to evaluate changes in salivary oxytocin concentrations following a physical effort and an induced psychological stress, which have previously been described as situations that cause an increase in salivary

The impact of oxytocin on emotion recognition and trust: Does disordered eating moderate these relationships? The current study aimed to investigate the impact of oxytocin on emotion recognition, trust, body image, affect, and anxiety and whether eating disorder (ED) symptoms moderated any of these relationships. Participants (n = 149) were female university students, who were randomly allocated to receive in a double-blind nature, a single dose of oxytocin intranasal spray (n = 76) or a placebo (saline) intranasal spray (n = 73). Participants were asked to complete an experimental measure of emotion recognition and an investor task aimed to assess trust. The oxytocin group exhibited better overall performance on the emotion recognition task (especially with recognising positive emotions

Changes in the analgesic mechanism of oxytocin can contribute to hyperalgesia in Parkinson's disease model rats. Pain is a major non-motor symptom of Parkinson's disease (PD). Alterations in the descending pain inhibitory system (DPIS) have been reported to trigger hyperalgesia in PD patients. However, the underlying mechanisms remain unclear. In the current study, dopaminergic nigrostriatal ) after formalin injection compared to sham-operated rats. Moreover, the 6-OHDA-lesioned rats also exhibited significantly lower plasma oxytocin (OT) concentration and percentage of oxytocin-immunoreactive (OT-IR) neurons expressing c-Fos protein in the mPVN and dorsal parvocellular division of the PVN (dpPVN), which secrete the analgesic hormone OT upon activation by nociceptive stimuli, when compared

WHO recommendation on umbilical vein injection of oxytocin for the treatment of retained placenta WHO recommendation onUmbilical vein injection of oxytocin for the treatment of retained placentaWHO recommendation onUmbilical vein injection of oxytocin for the treatment of retained placentaWHO recommendation on umbilical vein injection of oxytocin for the treatment of retained placentaISBN 978-92 of the World Intellectual Property Organization (http://www.wipo.int/amc/en/mediation/rules/).Suggested citation. WHO recommendation on umbilical vein injection of oxytocin for the treatment of retained placenta. Geneva: World Health Organization; 2020. Licence: CC BY-NC-SA 3.0 IGO.Cataloguing-in-Publication (CIP) data. CIP data are available at http://apps.who.int/iris.Sales, rights and licensing

WHO recommendation on routes of oxytocin administration for the prevention of postpartum haemorrhage after vaginal birth WHO recommendation onRoutes of oxytocin administration for the prevention of postpartum haemorrhage after vaginal birthWHO recommendation onRoutes of oxytocin administration for the prevention of postpartum haemorrhage after vaginal birthWHO recommendation on routes of oxytocin administration for the prevention of postpartum haemorrhage after vaginal birthISBN 978-92-4-001392-6 (electronic version) ISBN 978-92-4-001393-3 (print version)© World Health Organization 2020Some rights reserved. This work is available under the Creative Commons Attribution-NonCommercial-ShareAlike 3.0 IGO licence (CC BY-NC-SA 3.0 IGO; https://creativecommons.org/licenses/by-nc-sa/3.0/igo

The bilevel chamber revealed differential involvement of vasopressin and oxytocin receptors in female mouse sexual behavior. Arginine vasopressin (AVP) and oxytocin (OT) are well-known as neuropeptides that regulate various social behaviors in mammals. However, little is known about their role in mouse female sexual behavior. Thus, we investigated the role of AVP (v1a and v1b) and OT receptors

Epistatic interactions between oxytocin- and dopamine-related genes and trust. Trust is an essential human trait. Although research suggests that the interplay between oxytocinergic and dopaminergic systems affects trust formation, little research has focused on epistatic (i.e., gene by gene) interaction effects of oxytocin- and dopamine-related genes on trust. Using a sample of 348 adults (114 men), we aimed to investigate the associations between genetic variants in oxytocin- and dopamine-related genes and the general, neighborhood, and institutional trust with consideration of sex differences. Three-way interaction between oxytocin-related gene genotypes, dopamine-related genotypes, and sex was found for the oxytocin receptor gene (OXTR)rs1042778 and the Catechol-O-Methyltransferase

Continued versus discontinued oxytocin stimulation in the active phase of induced labour: factors associated with unexpectedly high rates of conversion to open label oxytocin in the CONDISOX trial. To examine the factors associated with unexpectedly high rates of conversion to open label oxytocin in the CONDISOX trial of continuation vs discontinuation of oxytocin infusion during induced labour . Secondary retrospective analysis of data from a prospective randomised controlled trial. Nine hospitals in Denmark and one in the Netherlands between 8 April 2016 and 30 June 2020. 1200 women having labour induced. Analysis of outcomes by actual management. Mode of delivery and associated variables. Switching to open label oxytocin (42.4% overall) was associated with nulliparity, an unripe cervix, larger

Pharmacokinetics and safety of inhaled oxytocin compared with intramuscular oxytocin in women in the third stage of labour: A randomized open-label study. To compare pharmacokinetics (PK) and safety of heat-stable inhaled (IH) oxytocin with intramuscular (IM) oxytocin in women in third stage of labour (TSL), the primary endpoint being PK profiles of oxytocin IH and secondary endpoint of safety . A phase 1, randomized, cross-over study was undertaken in 2 UK and 1 Australian centres. Subjects were recruited into 2 groups: Group 1, women in TSL; Group 2, nonpregnant women of childbearing potential (Cohort A, combined oral contraception; Cohort B, nonhormonal contraception). Participants were randomized 1:1 to: Group 1, oxytocin 10 IU (17 μg) IM or oxytocin 240 IU (400 μg) IH immediately after

Biosynthesis and function of VIP and oxytocin: mechanisms of C-terminal amidation, oxytocin secretion and transport. In this review, we provide the current status of research on vasoactive intestinal peptide (VIP) and oxytocin, typical C-terminal α-amidated peptide hormones, including their precursor protein structures, processing and C-terminal α-amidation, and the recently identified mechanisms of regulation of oxytocin secretion and its transportation through the blood brain barrier. More than half of neural and endocrine peptides, such as vasoactive intestinal peptide (VIP) and oxytocin, have the α-amide structure at their C-terminus, which is generally essential for biological activities. We have studied the synthesis and function of C-terminal α-amidated peptides, including VIP and oxytocin