"Pallor"

Optic Disc Pallor in Parkinson's Disease: A UK Biobank Study. Recent studies have suggested that retinal changes measured with optical coherence tomography are detectable in early Parkinson's disease (PD), highlighting the potential of ophthalmic biomarkers for diagnosis and monitoring. We set out to investigate the relationship between optic disc pallor measured in fundoscopy images and both prevalent and incident PD. We analyzed color fundus photographs from 787 UK Biobank participants: 89 with prevalent PD, 317 with incident PD, and 381 age- and sex-matched controls. Optic disc pallor in several zones was quantified using semi-automated software. We used logistic and linear regression, adjusted for relevant covariates, to test for associations between disc pallor and PD status and duration

Automatic computer-aided analysis of optic disc pallor in fundus photographs. Assessment of optic disc pallor in fundus photographs may be frequently misinterpreted due to the subjective nature of interpretation. We developed a fully automatic computer-aided detection (CAD) system for optic disc pallor using colour fundus photographs and evaluated the accuracy of the system. A newly proposed CAD system was developed for automated segmentation and image analysis of optic disc pallor, and a logistic regression model was developed for risk analysis. A total of 230 photographs with variable degree of optic disc pallor, and 123 normal optic discs confirmed by optical coherence tomography were tested for validation of the software. Sensitivity and specificity of the CAD system in automatic detection

Raynaud phenomenon causing lingual pallor and dysarthria

Role of vaginal pallor reaction in predicting late vaginal stenosis after high-dose-rate brachytherapy in treatment-naive patients with cervical cancer To assess actual rates of late vaginal stenosis and identify predisposing factors for complications among patients with previously untreated cervical cancer following high-dose-rate brachytherapy. We performed longitudinal analyses of 57 patients (severe) stenosis gradually increased with time. Actual stenosis rates for grade 1, 2, and 3 were 97.5% (95% confidence interval [CI], 92.7 to 97.5), 60.7% (95% CI, 42.2 to 79.3), and 7.4% (95% CI, 0 to 18.4) at 3 years after treatment. Pallor reaction grade 2-3 at 6 months was only a statistically significant predisposing factor for grade 2-3 late vaginal stenosis 3 years or later with a hazard ratio

The accuracy of clinical pallor to diagnose anemia in children: A systemic review and meta-analysis PROSPEROInternational prospective register of systematic reviews Print | PDFThe accuracy of clinical pallor to diagnose anemia in children: A systemic review and meta-analysisMounika Reddy, Yankappa N, Rashmi Kundapur, Bhushan Kamble, Vidya G, Akhil Goel, Suthanthira Kannan, Padmavathi STo enable here.CitationMounika Reddy, Yankappa N, Rashmi Kundapur, Bhushan Kamble, Vidya G, Akhil Goel, Suthanthira Kannan, Padmavathi S. The accuracy of clinical pallor to diagnose anemia in children: A systemic review and meta-analysis. PROSPERO 2023 CRD42023422027 Available from: https://www.crd.york.ac.uk/prospero/display_record.php?ID=CRD42023422027Review questionWhat is the accuracy of clinical pallor in the diagnosis

Breast irradiation causes pallor in the nipple-areolar complex in women with Celtic skin type (result from the St. George and Wollongong randomised breast boost trial). The nipple-areolar complex (NAC) has special histological properties with higher melanocyte concentration than breast skin. To date, there are no data describing the late effects on the NAC following breast-conserving therapy

Palmar Crease Pallor

or tongue Non-blanching petechial or purpuric rash For signs and symptoms of meningococcal disease, see the NICE guideline on bacterial meningitis and meningococcal septicaemia in under 16s. Pallor of skin, lips or tongue Temperature Any Less than 36ºC - Temperature Under 3 months 38°C or more - Temperature 3 to 6 months - 39°C or more Other Any - Leg pain Cold hands or feet Suspected sepsis: recognition

) • hyperpigmentation (primary adrenal insufficiency only) • hyponatraemia • hypoglycaemia (particularly in children) • circulatory shock or collapse • condition failing to respond to initial treatments. 1.6.2 Consider adrenal crisis in people with, or at high risk of, adrenal insufficiency (see recommendation 1.2.1) who are unwell with milder symptoms, including: • lethargy • pallor • clamminess • feeling cold

of the following: • pallor • persistent fatigue • unexplained fever • unexplained persistent or recurrent infection • generalised lymphadenopathy • unexplained bruising • unexplained bleeding • unexplained petechiae • hepatosplenomegaly. [2015] [2015] Leukaemia in children and young people Leukaemia in children and young people 1.10.2 Refer children and young people for immediate specialist assessment for leukaemia if they have unexplained petechiae or hepatosplenomegaly. [2015] [2015] 1.10.3 Offer a very urgent full blood count (within 48 hours) to assess for leukaemia in children and young people with any of the following: • pallor • persistent fatigue • unexplained fever • unexplained persistent infection • generalised lymphadenopathy Suspected cancer: recognition and referral (NG12)© NICE 2022. All

symptoms that on other occasions have been abolished by sitting or lying down • sweating before the episode • prolonged standing that appeared to precipitate the TLoC • pallor during the episode. Do not routinely use EEG in the investigation of TLoC (see NICE's guideline on epilepsies in children, young people and adults). Transient loss of consciousness ('blackouts') in over 16s (CG109)© NICE 2023. All

on defecation. [2012] [2012] 1.3.4 Be aware that ectopic pregnancy can present with a variety of signs on examination by a healthcare professional. Signs of ectopic pregnancy include: • more common signs: － pelvic tenderness － adnexal tenderness － abdominal tenderness • other reported signs: － cervical motion tenderness － rebound tenderness or peritoneal signs － pallor － abdominal distension － enlarged uterus

of retinal haemorrhage or papilloedema (accelerated hypertension) or or • life-threatening symptoms such as new onset confusion, chest pain, signs of heart failure, or acute kidney injury. [2019] [2019] 1.5.3 Refer people for specialist assessment, carried out on the same day, if they have suspected phaeochromocytoma (for example, labile or postural hypotension, headache, palpitations, pallor, abdominal

* periorbital ecchymosis (panda eyes) * subcutaneous skin nodules * family history of neuroblastic tumours * signs of spinal cord compression * signs of Horner's syndrome * signs of superior vena cava syndrome * intractable secretory diarrhoea * opsoclonus-myoclonus ataxia (OMA) Full detailsOther diagnostic factors * constipation * pallor * bleeding * infections * hypertension * hepatomegaly Full detailsRisk

symptoms such as dizziness, pallor, and sweating. According to the Rome foundation, chronic nausea is defined as bothersome nausea occurring several times per week, not usually associated with vomiting, in the absence of endoscopic or metabolic disease. These criteria must be fulfilled for the last 3 months, with the symptom onset at least 6 months prior to diagnosis.[1]Hyams JS, Di Lorenzo C, Saps M, et

vision with that of the clinician.[4] If a defect is identified, formal testing may be required, for example with Goldmann perimetry.Direct ophthalmoscopy: visualising the optic nerve as it enters the back of the eye can reveal pallor (optic atrophy) or disc swelling (papillitis or papilloedema).Oculomotor (III), trochlear (IV), and abducens (VI)AnatomyThe third cranial nerve emerges from the midbrain

* cannon a-waves in jugular venous pulse * jugular venous distension Full detailsOther diagnostic factors * increased intracranial pressure * abnormal heart sounds * abdominal or lower extremity oedema * hypotension * mental status changes * pallor * extremities cool to touch * hypothermia * chest pain * rashes * thyroid goitre Full detailsRisk factors * use of known causative medications * age >70 years

2024SummaryRaynaud's phenomenon (RP) is common, affecting between 3% and 5% of the population. The diagnosis is made clinically: digits turn white (pallor) then blue with deoxygenation and/or red with reperfusion; pallor is well demarcated. Primary RP often needs no pharmacological treatment. Keeping warm, smoking cessation, regular exercise, and avoiding stress are recommended. Pharmacological treatment can ulcers may be important adjunctive treatments. DefinitionRaynaud's phenomenon (RP) is characterised by vasospasm that causes digits to change colour to white (pallor) from lack of blood flow, usually brought on by cold temperatures. Affected areas subsequently turn blue due to de-oxygenation and/or red due to reperfusion. Both primary and secondary RP can be painful; however, secondary RP can lead

pain * eczema * faltering growth Full detailsOther diagnostic factors * abdominal pain/discomfort * borborygmi * flatulence * skin rashes * palpitations * history of asthma * history of peptic ulcer disease * history of gastro-oesophageal reflux disorder * nausea * vomiting * constipation * pallor * steatorrhoea * weight loss * short stature * progressive disability * flushing * sensory loss * oedema