Circular RNA expression alterations and function prediction in OSA-induced pancreaticinjury in mice: New insights into pathogenesis. Increasing studies have shown that circular RNAs (circRNAs) participate in the pathogenesis and progression of many diseases. However, the function of circRNAs in obstructive sleep apnea (OSA)-induced pancreatic damage has not been fully elucidated. In this study , the altered circRNA profiles in a chronic intermittent hypoxia (CIH) mouse model were investigated, aiming to provide novel clues for delineating the underlying mechanisms of OSA-induced pancreaticinjury. A CIH mouse model was established. circRNA microarray was then applied to profile circRNA expression in pancreatic samples from CIH groups and controls. Our preliminary findings were validated by qRT-PCR
Recent Changes in the Management of High-Grade Blunt PancreaticInjury in Children: A Nationwide Trend Analysis. The optimal management of pediatric patients with high-grade blunt pancreaticinjury (BPI) involving the main pancreatic duct remains controversial. This study aimed to assess the nationwide trends in the management of pediatric high-grade BPI at pediatric (PTC), mixed (MTC
Resolution of acinar dedifferentiation regulates tissue remodeling in pancreaticinjury and cancer initiation. Acinar to ductal metaplasia (ADM) is crucial in the development of pancreatic ductal adenocarcinoma (PDAC). However, our understanding of the induction and resolution of ADM remains limited. We conducted comparative transcriptome analyses to identify conserved mechanisms of ADM in mouse of acinar-derived metaplastic cells in pancreaticinjury and cancer initiation and is activated upon Kras ablation and tumor regression in mice. By uncovering novel potential strategies to promote tissue homeostasis, our findings offer new avenues for preventing the development of PDAC.
Use of Endoscopic Retrograde Cholangiopancreatography in the Diagnosis and Management of Pediatric PancreaticInjury. ERCP is the gold standard for evaluating the integrity of the main pancreatic duct (MPD); however, ERCP is underutilized in evaluating MPD integrity in pediatric blunt pediatric injury. The primary aim of this study was to evaluate the discordance of cross-sectional imaging (CSI ) and ERCP in children with suspected MPD injury. A retrospective review of all patients age ≤18 years with CSI or clinical findings suggestive of MPD injury (MPDI) and ERCP was conducted at a level I pediatric trauma center from January 2009 to May 2023. Demographic and clinical data were collected. Pancreaticinjury findings were compared between cross-sectional imaging and ERCP. An ERCP was performed
Clinical insights into drug-associated pancreaticinjury. Drug-induced pancreatitis is one of the top three causes of acute pancreatitis. A drug exposure is traditionally determined to be the cause of pancreatitis only after other possible and common causes of pancreatitis have been excluded. In this review, we challenge this traditional notion of drug-induced pancreatitis as a diagnosis of exclusion. Instead, we propose to shift the paradigm of conceptualizing what we term drug-associated pancreaticinjury (DAPI); as a continuum of pancreaticinjury that can be concomitant with other risk factors. The aims of this targeted review are to harness recent literature to build a foundation for conceptualizing DAPI, to highlight specific drugs associated with DAPI, and to describe a framework
Single-Cell Transcriptomics Reveals a Conserved Metaplasia Program in PancreaticInjury. Acinar to ductal metaplasia (ADM) occurs in the pancreas in response to tissue injury and is a potential precursor for adenocarcinoma. The goal of these studies was to define the populations arising from ADM, the associated transcriptional changes, and markers of disease progression. Acinar cells were
PancreaticInjuriesPancreaticInjuries - Practice Management Guideline Skip to main content Eastern Association for the Surgery of Trauma * Jobs * Fellowships * News & Events * Find a Member * Search * Search * Sign inWhat can we help you find? Submit * Education & Career Development * Annual Scientific Assembly * Practice Management Guidelines * Online Education : Vanessa.Ho@uhhospitals.org.OverviewTraumatic injuries to the pancreas are infrequent but can be associated with major morbidity and mortality, including acute hemorrhage, pancreatic leaks, abscesses, fistulae, and pancreatitis.[1] Estimates for the incidence of pancreaticinjury range from 0.2% to 12% of abdominal traumas.[2–6] Many factors, such as patient stability, the acuity of concomitant life
Acute pancreaticinjuries: A complication of Stevens-Johnson syndrome/toxic epidermal necrolysis associated with cytotoxic immune cell activation. Complications involving internal organs are usually present in Stevens-Johnson syndrome (SJS) and toxic epidermal necrolysis (TEN). However, pancreatic complications are rarely reported and studied. To summarize clinical characteristics of SJS/TEN -associated acute pancreaticinjuries and to investigate underlying inflammatory mechanisms. Clinical records of 124 inpatients with SJS/TEN were reviewed. Serum levels of tumor necrosis factor α, interleukin (IL) 6, IL-18, IL-15, IL-12p70, and soluble CD56 were determined in 18 healthy donors and 17 patients with SJS/TEN, including 3 with acute pancreaticinjuries. Acute pancreaticinjury was diagnosed
Macrophage phenotypic switch orchestrates the inflammation and repair/regeneration following acute pancreatitisinjury. Impaired or hyperactive pancreas regeneration after injury would cause exocrine insufficiency or recurrent / chronic pancreatitis and potentially carcinogenesis. Macrophages are the most abundant immune cells in the regenerative pancreas, however their phenotype and role remain
Epidemiological state, predictive model for mortality, and optimal management strategy for pancreaticinjury: A multicentre nationwide cohort study. Data for establishing the optimal management modalities for pancreaticinjury are lacking. Herein, we aimed to describe the epidemiology, identify mortality predictors, and determine the optimal management strategy for pancreaticinjury. We identified patients with pancreaticinjury between 2004 and 2017 recorded in the Japan Trauma Data Bank. The primary outcome was mortality. Multivariable logistic regression analyses were used to identify factors significantly associated with mortality and to develop a predictive model. Patients were also classified according to the Organ Injury Scaling of the American Association for the Surgery of Trauma
Lessons learned from isolated blunt major pancreaticinjury: Surgical experience in one trauma centre. The aim of this study was to present our surgical experience of isolated blunt major pancreaticinjury (IBMPI), and to compare its characteristic outcomes with that of multi-organ injury. From 1994-2015, 31 patients with IBMPI and 54 patients with multi-organ injury, who underwent surgery, were
Parenteral Nutrition Prolongs Hospital Stay in Children with Nonoperative Blunt PancreaticInjury: A Propensity Score Weighted Analysis. Blunt pancreaticinjury is frequently managed nonoperatively in children. Nutritional support practices - either enteral or parenteral - are heterogeneous and lack evidence-based guidelines. We hypothesized that use of parenteral nutrition (PN) in children with nonoperatively managed blunt pancreaticinjury would 1) be associated with longer hospital stay and more frequent complications, and 2) differ in frequency by trauma center type. We conducted a retrospective cohort study using the National Trauma Data Bank (2007-2016). Children (≤18 years) with blunt pancreaticinjury were included. Patients were excluded for duodenal injury, mortality <4 days from admission
Analysis of Risk Factors of PancreaticInjury during Elective Laparoscopic Splenectomy in Children. Laparoscopic splenectomy (LS) became the standard choice for splenectomy in children with benign hematological disease. There are few reports about pancreaticinjury during LS. The purpose of this study is to spot on factors increasing the risk of pancreaticinjury during LS in children. A total girls had LS. The mean splenic size was 13.50 cm in Group A and 12.51 cm in Group B. The mean operative time in Group A was 41.91 min and in Group B was 56.36 min. The mean level of amylase was 42.99 IU/ml in Group A and 75.70 IU/ml in Group B ( = 0.001). The mean level of lipase was 37 IU/ml in Group A and 76.66 IU/ml in Group B ( = 0.001). Pancreaticinjury during LS is a rare complication usually
An Unlikely Cause of a Blunt PancreaticInjury. We report the case of a 17-year-old male football player with blunt abdominal trauma. Careful evaluation, including computed tomography and laboratory, revealed a pancreatic body laceration. Pancreaticinjuries are relatively uncommon and associated with significant morbidity and mortality and require early diagnosis for optimal management
TRIM21 Restricts Coxsackievirus B3 Replication, Cardiac and PancreaticInjury via Interacting With MAVS and Positively Regulating IRF3-Mediated Type-I Interferon Production Tripartite motif-containing 21 (TRIM21) is a regulator of tissue inflammation and pro-inflammatory cytokine production, and has been implicated in negative regulation of IRF3-dependent type I interferon signaling. However cardiac and pancreatic CVB3 replication, and aggravated pancreaticinjury as well as myocarditis during acute infection. Thus, our results demonstrate TRIM21 as a positive regulator of IFN-β signaling by targeting MAVS during CVB3 infection and suggest it as a potent host defense against CVB3 infection and viral-induced injury in hearts and pancreas.
Evaluation of Circulating MicroRNA Biomarkers in the Acute PancreaticInjury Dog Model This study aimed to evaluate the usefulness of four microRNAs (miRNAs) in an acute pancreaticinjury dog model. Acute pancreatitis was induced by infusion of cerulein for 2 h (7.5 μg/kg/h). The levels of well-known miRNAs, microRNA-216a (miR-216a) and microRNA-375 (miR-375), and new candidates microRNA-551b expression levels, from initial increase to decrease by predose level in acute pancreatitis. Our findings demonstrate that, in dogs, miR-216a and miR-375 have the potential to sensitively detect pancreatitis and reflect well the degree of pancreaticinjury, whereas miR-551b and miR-7 do not.
Isoliquiritigenin Protects Against PancreaticInjury and Intestinal Dysfunction After Severe Acute Pancreatitis via Nrf2 Signaling Severe acute pancreatitis (SAP) is a digestive system disease that is associated with a range of complications including intestinal dysfunction. In this study, we determined that the chalcone compound, isoliquiritigenin (ISL), reduces pancreatic and intestinal injury dismutase (SOD). We then used Nrf2 mice to test the protective effect of Nrf2 during ISL treatment of SAP. Our results indicated that Nrf2 mice had greater pancreaticinjury and intestinal dysfunction than wild-type mice. They also had reduced adherens junctions (P120-catenin) and tight junctions (occludin), and increased activated nuclear factor-κB (NF-κB) protein. In Nrf2 mice, ISL was less effective
Co-sequencing and novel delayed anti-correlation identify function for pancreatic enriched microRNA biomarkers in a rat model of acute pancreaticinjury Co-sequencing of messenger ribonucleic acid (mRNA) and micro ribonucleic acid (miRNA) across a time series (1, 3, 6, 24, and 48 h post injury) was used to identify potential miRNA-gene interactions during pancreaticinjury, associate serum and tissue levels of candidate miRNA biomarkers of pancreaticinjury, and functionally link these candidate miRNA biomarkers to observed histopathology. RNAs were derived from pancreatic tissues obtained in experiments characterizing the serum levels of candidate miRNA biomarkers in response to acute pancreaticinjury in rats. No correlation was discovered between tissue and serum levels of the miRNAs
Total body irradiation and iron chelation treatment are associated with pancreaticinjury following pediatric hematopoietic stem cell transplantation Whereas many studies have addressed the risk of organ dysfunction following hematopoietic stem cell transplantation (HSCT), little is known about pancreatic susceptibility in this setting. We aimed to investigate the effect of iron overload (IO
Blunt PancreaticInjury in Major Trauma: Decision-Making between Nonoperative and Operative Treatment Blunt trauma injuries to the pancreas are rare but are associated with significant overall mortality and a high complication rate. Motor vehicle collisions are the leading cause of blunt pancreatic trauma, followed by falls, and sports injuries. We discuss the decision-making process used during the clinical courses of 3 patients with life-threatening blunt pancreaticinjuries caused by traumatic falls. We also discuss the utility of the American Association for the Surgery of Trauma Organ Injury Scale (AAST-OIS), which provides a system for grading pancreatic trauma. Retrospectively, the cases reviewed were classified as AAST-OIS grade II, III, and IV in each one patient. Although the nonoperative