Cinacalcet hydrochloride (Mimpara) - Secondary hyperparathyroidism (HPT) or Parathyroidcarcinoma and primary HPT in adults Published 9 March 2020 www.scottishmedicines.org.uk Statement of advice SMC2275 cinacalcet hydrochloride 1mg, 2.5mg and 5mg granules in capsules for opening (Mimpara®) Amgen Ltd 7 February 2020 Advice context: No part of this advice may be used without is not adequately controlled with standard of care therapy Parathyroidcarcinoma and primary HPT in adults Reduction of hypercalcaemia in adult patients with: parathyroidcarcinoma. primary HPT for whom parathyroidectomy would be indicated on the basis of serum calcium levels (as defined by relevant treatment guidelines), but in whom parathyroidectomy is not clinically appropriate
Neuroendocrine neoplasms of head and neck, genitourinary and gynaecological systems, unknown primaries, parathyroidcarcinomas and intrathyroid thymic neoplasms: ESMO Clinical Practice Guideline for diagnosis, treatment and follow-up www.esmoopen.comVerify you are human by completing the action below.www.esmoopen.com needs to review the security of your connection before proceeding.Ray ID
PI3K/AKT/mTOR Activation is Associated with Malignant Severity and Poorer Prognosis in ParathyroidCarcinomas. Parathyroidcarcinoma (PCa) is a rare endocrine neoplasm known for its high recurrence. The specific molecular properties influencing the prognosis of PCa remain largely elusive. The present study was designed to explore the significance of PI3K/AKT/mTOR activation in PCa. Over a 10
Incidental synchronous intrathyroidal parathyroidcarcinomas and papillary thyroid microcarcinoma with compressive neck mass and primary hyperparathyroidism: case report and literature review. Parathyroidcarcinoma (PC) is a rare malignancy, often diagnosed incidentally through postoperative pathological examination. The occurrence of nodular goiter, intrathyroidal parathyroidcarcinoma dissection was performed due to suspicion of an aggressive malignant tumor. Histology and immunohistochemistry analysis revealed incidental intrathyroidal parathyroidcarcinoma, contralateral parathyroid adenoma, classical papillary thyroid microcarcinoma, and nodular goiter. Parathyroidcarcinoma should be highly suspected when extremely high levels of PTH and severe hypercalcemia are present, which
Acute pancreatitis and refractory hypercalcemia in the third trimester caused by parathyroidcarcinoma. Hypercalcemia can be a rare contributor to acute pancreatitis (AP) in pregnancy. This is primarily due to primary hyperparathyroidism (PHPT), resulting from parathyroidcarcinoma. We exhibited a case report to analyze the diagnosis and treatment during the onset of hypercalcemia-induced AP . The final histopathology suggested parathyroidcarcinoma. When refractory hypercalcemia is present, serum PTH levels should be measured to determine PHPT. Parathyroidectomy is the optimal strategy for alleviating hypercalcemia and clarifying the underlying pathology.
Risk Factors of Distant Metastatic ParathyroidCarcinoma and Insights into Therapeutic Perspectives. Distant metastatic parathyroidcarcinoma (DM-PC) is a rare but often lethal entity with limited data about prognostic indicators. We sought to investigate the risk factors, patterns, and outcomes of DM-PC. In this observational cohort study, 126 patients who underwent surgery for PC at a tertiary
Parathyroidcarcinoma and atypical parathyroid tumor: Analysis of an Italian database. Atypical parathyroid tumor (aPT) and parathyroidcarcinoma (PC) are extremely rare parathyroid neoplasms, accounting together for less than 2% of all parathyroid tumors. They often present an overlapping clinical phenotype, sharing clinical, biochemical, and some histological features. They are distinguished
In-depth Proteomic Signature of ParathyroidCarcinoma. Diagnosing parathyroidcarcinoma (PC) is complicated and controversial that early diagnosis and intervention are often difficult. Therefore, we aimed to elucidate the protein signatures of PC through quantitative proteomic analyses to aid in the early and accurate diagnosis of PC. Retrospective cohort study. We performed liquid
Single-cell transcriptomic atlas of parathyroid adenoma and parathyroidcarcinoma. Primary hyperparathyroidism is typically characterized by monoclonal parathyroid tumors that secrete an excessive amount of parathyroid hormone (PTH). However, the underlying pathogenesis of tumorigenesis remain unclear. We performed single-cell transcriptomic analysis on five parathyroid adenomas (PA) and two PC
Mediastinal parathyroidcarcinoma: a case report and review of the literature. Parathyroidcarcinoma (PC) is an uncommon cause of primary hyperparathyroidism (PHPT) and particularly rare in the mediastinum. Herein, we present a case of mediastinal PC and conduct a related literature review. We described a case of a 50-year-old female patient with PHPT due to mediastinal PC. She was initially
Recurrence hyperparathyroidism caused by synchronous parathyroidcarcinoma and parathyromatosis in a patient with long-term hemodialysis. Parathyroidcarcinoma and parathyromatosis are very rare diseases in patients on hemodialysis. Its pathogenesis, clinical features, preoperative diagnosis, and surgery are challenging. We describe a rare case of recurrent hyperparathyroidism due to synchronous parathyroidcarcinoma and parathyromatosis. A 46-year-old Chinese woman was diagnosed with end-stage renal disease and received regular hemodialysis. Four years later, she experienced discomfort due to itching and was diagnosed with drug-resistant secondary hyperparathyroidism. Parathyroidectomy was performed, and her parathyroid hormone (PTH) levels were reduced. The pathology also revealed that the four
Left parathyroidcarcinoma with secondary hyperparathyroidism: a case report. Parathyroidcarcinoma is a rare disease with a frequency of 0.005% of all malignancies [1, 2]. Various aspects of its pathogenesis, diagnosis, and treatment remain poorly understood. Furthermore, cases with secondary hyperparathyroidism are fewer. In this case report, we describe a case of left parathyroidcarcinoma . Laryngeal endoscopy revealed paralysis of the left vocal cord, signifying recurrent nerve palsy due to parathyroidcarcinoma. Based on these results, a diagnosis of secondary hyperparathyroidism and suspected left parathyroidcarcinoma was made, and the patient underwent surgery. Pathology results revealed hyperplasia in the right upper and lower parathyroid glands. The left upper parathyroid gland showed
Prognostic Analysis for Patients With ParathyroidCarcinoma: A Population-Based Study. Parathyroidcarcinoma (PC) is a rare but often lethal malignancy for which staging system, prognostic indicators, and treatment guidelines are still not established. We aimed to explore the prognostic parameters and construct a nomogram for cancer-specific survival (CSS) of PC. A retrospective analysis of 604
Clinical Presentation, Treatment, and Outcome of ParathyroidCarcinoma: Results of the NEKAR Retrospective International Multicenter Study. In this retrospective cohort study, we describe the clinical presentation and workup of parathyroidcarcinoma (PC) and determine its clinical prognostic parameters. Primary outcome was recurrence free survival. PC is an orphan malignancy for which diagnostic
Extended En Bloc Reoperation for Recurrent or Persistent ParathyroidCarcinoma: Analysis of 31 Cases in a Single Institute Experience. Parathyroidcarcinoma (PC) is a rare malignancy that is difficult to eradicate completely after recurrence. We assessed the efficiency of extended en bloc resection (EEBR) in the management of recurrent or persistent PC. In this observational cohort study, 31
Parathyroidcarcinoma during pregnancy: a novel pathogenic CDC73 mutation - a case report. Parathyroidcarcinoma is an uncommon cause of PTH-dependent hypercalcemia. Only a handful of cases have been reported of parathyroidcarcinoma during pregnancy. Twenty-four - Year - old female presented with proximal myopathy was found to have hypercalcemia. Her serum corrected total calcium was - 15 mg/dl hyperparathyroidism. Her ultrasound scan of the neck revealed a well-defined discreate hypoechoic nodule, superior to the thyroid isthmus which was confirmed by a non-contrast MRI scan of the neck. She underwent an uncomplicated second trimester parathyroid tumour excision with normalization of post op PTH. Her histology revealed a parathyroidcarcinoma with vascular and capsular invasion. Her genetic studies
The Use and Benefit of Adjuvant Radiotherapy in ParathyroidCarcinoma: A National Cancer Database Analysis. The routine use of external beam radiotherapy (EBRT) is not recommended for parathyroidcarcinoma (PC). However, case series have demonstrated a potential benefit in preventing local recurrence with EBRT. We aimed to characterize the patient population treated with EBRT and identify any impact of EBRT on overall survival (OS) in parathyroidcarcinoma. Patients who underwent surgery for PC from 2004 to 2016 were identified from the National Cancer Database. Clinicopathologic variables and OS were compared between patients based on treatment with EBRT. Multivariable logistic and Cox regression models were performed with propensity scores and inverse-probability-weighting (IPW
HEREDITARY ENDOCRINE TUMOURS: CURRENT STATE-OF-THE-ART AND RESEARCH OPPORTUNITIES: New and future perspectives for parathyroidcarcinoma. This report summarizes published data on parathyroid cancer, with the inclusion of topics discussed at MEN2019: 16th International Workshop on Multiple Endocrine Neoplasia, 27-29 March 2019, Houston, TX, USA. An expert panel on parathyroid cancer search. All presentations were based upon the best peer-reviewed information taking into account the historical and current literature. Questions were developed by the expert panel on parathyroidcarcinoma. A comprehensive literature search for relevant studies was undertaken. This report represents the expert panel's synthesis of the conference material placed in a context designed to be relevant
Case report of parathyroidcarcinoma in a pediatric patient. Parathyroidcarcinoma is extremely rare in pediatric population. The authors report a case of 15-year-old girl with extremely elevated serum calcium (4.1 mmol/L) and parathyroid hormone (1170 pg/mL), with palpable neck mass. After en bloc resection, the patient remained normocalcemic within the next 2 years. To the best of our knowledge , this is the fourteenth documented case of parathyroidcarcinoma in patients younger than 16 years. Even though parathyroidcarcinoma is very uncommon in children with good prognosis, this diagnosis has to be considered when a child has severe hypercalcemia, elevated parathyroid hormone and palpable neck mass.