"Phantom pain"

A novel mixed reality system to manage phantom pain in-home: results of a pilot clinical trial. Mirror therapy for phantom limb pain (PLP) is a well-accepted treatment method that allows participants to use a mirror to visually perceive the missing limb. Mixed reality options are now becoming increasingly available, but an in-home virtual mirror therapy option has yet to be adequately investigated. We had previously developed a mixed reality system for Managing Phantom Pain (Mr. MAPP) that registers the intact limb and mirrors it onto the amputated limb with the system's visual field, allowing the user to engage with interactive games targeting different large lower limb movements. Feasibility and pilot outcomes of treating patients with lower extremity PLP by using Mr. MAPP at home for 1

Additive Analgesic Effect of Transcranial Direct Current Stimulation Together with Mirror Therapy for the Treatment of Phantom Pain. Current analgesic treatments for phantom pain are not optimal. One well-accepted yet limited nonpharmacological option is mirror therapy, which is thought to counterbalance abnormal plasticity. Transcranial direct current stimulation (tDCS) is an emerging approach believed to affect the membrane potential and activity threshold of cortical neurons. tDCS analgesic effectiveness, however, is mild and short, rendering it a noneffective stand-alone treatment. This study aimed to assess if a combination of mirror therapy with tDCS results in a superior analgesic effect as compared with mirror therapy alone in patients suffering from phantom pain due to recent

Targeted Muscle Reinnervation Treats Neuroma and Phantom Pain in Major Limb Amputees: A Randomized Clinical Trial To compare targeted muscle reinnervation (TMR) to "standard treatment" of neuroma excision and burying into muscle for postamputation pain. To date, no intervention is consistently effective for neuroma-related residual limb or phantom limb pain (PLP). TMR is a nerve transfer

Sensory feedback restoration in leg amputees improves walking speed, metabolic cost and phantom pain. Conventional leg prostheses do not convey sensory information about motion or interaction with the ground to above-knee amputees, thereby reducing confidence and walking speed in the users that is associated with high mental and physical fatigue. The lack of physiological feedback from

Motor Control and Sensory Feedback Enhance Prosthesis Embodiment and Reduce Phantom Pain After Long-Term Hand Amputation We quantified prosthesis embodiment and phantom pain reduction associated with motor control and sensory feedback from a prosthetic hand in one human with a long-term transradial amputation. Microelectrode arrays were implanted in the residual median and ulnar arm nerves ., without sensory feedback), open-loop sensation from the prosthesis (i.e., without motor control), and closed-loop control of the prosthesis (i.e., motor control with sensory feedback). There was also a statistically significant reduction in reported phantom pain after experimental sessions that included open-loop nerve microstimulation, open-loop prosthesis motor control, or closed-loop prosthesis motor

Phantom PAINS: Problems with the Utility of Alerts for Pan-Assay INterference CompoundS The use of substructural alerts to identify Pan-Assay INterference compoundS (PAINS) has become a common component of the triage process in biological screening campaigns. These alerts, however, were originally derived from a proprietary library tested in just six assays measuring protein-protein interaction

the Influence of Virtual Reality Approach on Phantom Pain in Trans Tibial Amputation: A Randomized Control Trail To investigate the effect of Virtual reality (VR) on phantom limb pain in trans tibial amputation.To investigate the effect of Virtual reality (VR) on lower limb Function in trans tibial amputation.A sample size of 60 will be randomly allocated to two groups(30 in each group ) , by using computer-generated random number list method. Control group will receive conventional physiotherapy(TENS- Phantom exercises and mirroring exercise) for reducing phantom pain in trans -tibial amputation and the experimental group will receive conventional physiotherapy(TENS- Phantom exercises and mirroring exercise) and Virtual Reality for reducing phantom pain in trans -tibial amputation . Pain

Effects of organized physical activity on quality of life and phantom pain among adults with lower limb amputation: a systematic review and meta-analysis PROSPERO International prospective register of systematic reviews Print | PDF PROSPERO This information has been provided by the named contact for this review. CRD has accepted this information in good faith and registered the review in PROSPERO

Assessing the Feasibility of a Virtual Reality Intervention for Phantom Pain Immediately Following Lower Limb Amputation The goal of this observational study is to see whether a new virtual reality (VR) program meant to treat phantom limb pain (PLP) is feasible to people immediately following lower limb amputation. This study aims to answer three questions. 1. Is this VR treatment acceptable

Reversal of phantom pain and hand‐to‐face remapping after brachial plexus avulsion Following left brachial plexus avulsion, a 20-year-old man had phantom limb pain and remapping of sensation from his paralyzed hand onto his face. Mirror therapy (15 min daily, 5 days/week) led immediately to good movement of the phantom limb with decreased pain. Within 2 weeks following nerve graft surgery

Phantom pain in a patient with brachial plexus avulsion injury. Phantom limb pain is a painful sensation perceived in the absent limb following surgical or traumatic amputation. Phantom limb sensations, which are nonpainful, occur in nearly all amputees. Deafferentation can also produce similar symptoms. Here we report the presence of phantom pain in a deafferented limb. Case report. Hospital of the scapula. Electrodiagnostic studies showed a left brachial plexopathy consistent with multilevel nerve root avulsion sparing the dorsal rami. This is a report of phantom limb sensations and phantom pain following BPA in an intact but flaccid and insensate limb.

Efficacy and safety of Pharmacological interventions in Phantom Pain and amputation related outcomes PROSPEROInternational prospective register of systematic reviews Print | PDFEfficacy and safety of Pharmacological interventions in Phantom Pain and amputation related outcomesRamin Abrishami, Nima Azh, Hamid BaradaranTo enable PROSPERO to focus on COVID-19 submissions, this registration record of Pharmacological interventions in Phantom Pain and amputation related outcomes. PROSPERO 2023 CRD42023385291 Available from: https://www.crd.york.ac.uk/prospero/display_record.php?ID=CRD42023385291Review questionWhat is the efficacy and safety profile of different pharmacological interventions (e.g. anti-depressants, NSAIDs, Benzodiazepines) compared to placebo, no treatment, or other treatments

Study of Lower-limb Phantom Pain Syndrome Using Peripheral Nerve and Spinal Cord Stimulation Brief Summary: The purpose of this study is to evaluate the effectiveness of neuromodulation for relief of phantom limb pain (PLP) using peripheral nerve (PNS) and spinal cord (SCS) stimulation with implantable electrodes. The researchers expect that PLP in patients with lower limb amputation will be relieved by peripheral nerve and the spinal cord stimulation. The possibility of finding EEG biomarkers for phantom pain will be explored. The purpose of this study is to evaluate the effectiveness of neuromodulation for relief of phantom limb pain (PLP) using peripheral nerve (PNS) and spinal cord stimulation (SCS) with implantable electrodes.The study is conducted to collect information on the role

Prevalence and psychological repercussion of phantom pain in women undergoing mastectomy: a systematic review Prevalence and psychological repercussion of phantom pain in women undergoing mastectomy: a systematic review Print | PDF PROSPERO This information has been provided by the named contact for this review. CRD has accepted this information in good faith and registered the review in PROSPERO

Methods for the application of mirror therapy in amputates with complaints of phantom pain: A systematic review Methods for the application of mirror therapy in amputates with complaints of phantom pain: A systematic review Print | PDF PROSPERO This information has been provided by the named contact for this review. CRD has accepted this information in good faith and registered the review

Mirror therapy in the treatment of phantom pain in amputee patients: a systematic review PROSPEROInternational prospective register of systematic reviews Print | PDFMirror therapy in the treatment of phantom pain in amputee patients: a systematic reviewWilliam Feitosa Araújo Costa, Mayra de Brito Saraiva, Jordano Leite Cavalcante de MacêdoTo enable PROSPERO to focus on COVID-19 submissions , Jordano Leite Cavalcante de Macêdo. Mirror therapy in the treatment of phantom pain in amputee patients: a systematic review. PROSPERO 2022 CRD42022382446 Available from: https://www.crd.york.ac.uk/prospero/display_record.php?ID=CRD42022382446Review questionDoes mirror therapy have efficacy in reducing phantom pain in patients with amputee limb?SearchesNational Library of Medicine (PubMed

Neural Bases of Phantom Pain After Amputation The amputation of a limb results in chronic pain associated with the lost limb in the majority of patients, which persists over time. Despite a large number of studies conducted in an attempt to elucidate the neural basis of phantom pain, these are still not elucidated and current treatments often fail to relieve patients' pain. undefined

Rethinking the role of the brain in driving phantom pain

Mixed Reality Based System to Manage Phantom Pain Phantom Pain for Patients With Lower Limb Amputation The primary goals of this pilot research project are a) to design and develop the a mixed reality based system for managing phantom pain and b) to evaluate the feasibility and preliminary functional outcomes of this system in a sample of patients with lower limb amputation. Findings from this pilot study will serve as preliminary data to inform regarding a fully powered clinical trial to determine the effectiveness and practical implementation of these findings in real-world settings.Aim1: Design and develop a feasible mixed reality based system to manage phantom pain in patients with lower limb amputation qualifying for on-going mirror therapy.Hypothesis 1: The investigators hypothesize

An Alternative to Traditional Mirror Therapy: Illusory Touch Can Reduce Phantom Pain When Illusory Movement Does Not. There is evidence that amputation leads to cortical reorganization, and it has been suggested that phantom pain might be related to a consequently emerging incongruence of motor intention, somatosensation and visual feedback. One therapeutic approach that has the potential study we therefore implemented an alternative version of the mirror therapy involving a visuotactile illusion, to explore whether it might be effective with amputees for whom the action of moving the phantom increases phantom pain. We recruited six upper limb amputees who had been previously exposed to the classical mirror therapy with no or limited success, and exposed them to two differential