"Phenindione"

/protocols. * For people on low dose methotrexate, consult local or national guidelines/protocols for recommendations on appropriate monitoring and management. * Mycophenolate mofetil — reduction in the level of active metabolite may occur when given with co-amoxiclav. Monitor mycophenolate efficacy. * Oral anticoagulants (warfarin, phenindione) — prolongation of prothrombin time has been reported

. [BNFC, 2024; EMC, 2024] Drug interactions * Aminoglycosides (for example gentamicin) — possible increased risk of nephrotoxicity. Routine renal monitoring for the aminoglycoside is usually adequate. * Oral anticoagulants (warfarin and phenindione) — cefalexin may enhance the anticoagulant effect. Monitor the international normalized ratio (INR) closely during concomitant use. * Probenecid — renal

for people on low-dose methotrexate. * Mycophenolatemofetil— amoxicillin reduces exposure to mycophenolate. Monitor for efficacy. * Coumarin anticoagulants (warfarin and phenindione) — INR may be increased. Monitor INR within 3 days of starting or stopping amoxicillin. * Live cholera vaccines — the efficacy of the live vaccine may be affected. Avoid concurrent use and for 14 days before, and for 10 days

K antagonists (VKAs; acenocoumarol and phenindione) work by inhibiting the vitamin K-dependent modification of prothrombin and other coagulation factors, which is required for their normal function. Warfarin has a number of Management of Dental Patients Taking Anticoagulants or Antiplatelet Drugs 2 Anticoagulants and Antiplatelet Drugs 5 limitations, including a narrow therapeutic range

if breastfeedingConcerns exist for: * Amiodarone * Chemotherapeutic/antineoplastic agents * Chloramphenicol * Ergotamine * Gold salts * Phenindione * Radioactive pharmaceuticals * Retinoids * Tetracyclines (chronic > 3 weeks) * Certain psychotropic medications * Codeine * PseudoephedrineCopied from: https://www.aap.org/en-us/Pages/Breastfeeding-and-Medication.aspxFor more resources on this, see: * https

oral anticoagulants? Sue Dickinson, Director of Pharmacy, Regional Drug & Therapeutics Centre (Newcastle) · Published 17 September 2018 Topics: Acenocoumarol · Administering · Apixaban · 9 more Coumarin · Dabigatran etexilate · Edoxaban · Influenza vaccine · Phenindione · Phenprocoumon · Rivaroxaban · Vaccinating · Warfarin · Less This Medicines Q&A discusses the potential risks associated

be given to patients taking oral anticoagulants? Sue Dickinson, Director of Pharmacy, Regional Drug & Therapeutics Centre (Newcastle) · Published 17 September 2018 Topics: Acenocoumarol · Administering · Apixaban · 9 more Coumarin · Dabigatran etexilate · Edoxaban · Influenza vaccine · Phenindione · Phenprocoumon · Rivaroxaban · Vaccinating · Warfarin · Less This Medicines Q&A discusses the potential

to ensure haemostasis has returned to normal. This is likely to differ for other vitamin K antagonists with different half-lives (acenocoumarol 10 hours, phenindione 8 hours, fluindione 3 days, phenprocoumon 5 days). If possible the INR should be determined the day before surgery to allow the administration of phytomenadione if the INR is ≥ 1.5 so reducing the risk of cancellation. The INR should . exp Anticoagulants/ 6. (anticoagula* or 4-hydroxycoumarins or Acenocoumarol or Dicumarol or Heparin or Heparin, low-molecular-weight or Phenindione or Phenprocoumon or Warfarin or Dabigatran or Rivaroxaban or Apixaban or Edoxaban).tw. 7. (thrombin* adj2 inhibitor*).tw. 8. or/1-7 9. exp Perioperative Care/ 10. (perioperative or periprocedural).tw. 11. (pre-operative or intra-operative or post

anticoagulants available in the UK are warfarin, acenocoumarol, phenindione, dabigatran etexilate, rivaroxaban, edoxaban and apixaban[1].Warfarin continues to be the most widely used oral anticoagulant but the use of the newer oral anticoagulants (dabigatran etexilate, rivaroxaban, edoxaban and apixaban) is increasing.Warfarin antagonises vitamin K (needed for the synthesis of clotting factors) and takes 2-3

antithrombotic drugs who experience significant bleeding or who require emergency surgery or an invasive procedure. Guidance on reversal of vitamin K antagonists (VKAs; warfarin, phenprocoumon, acenocoumarol (sinthrome) and phenindione has been described previously (Keeling et al , ). Antithrombotic drugs are used increasingly in patient groups at greater bleeding risk. Although major haemorrhage is infrequent K to have time to take effect, the INR can be corrected by giving PCC and intravenous vitamin K. PCC should not be used to enable elective or non‐urgent surgery (2C). Other vitamin K antagonists Whilst warfarin is the main coumarin used in the UK and North America, the VKA drugs phenprocoumon, acenocoumarol (sinthrome) and phenindione are also available and widely used in some countries. All drugs

. Potassium iodide 7. Phenindione (Anticoagulant) 5. Drugs of Abuse 1. Amphetamine 2. Cocaine 3. Heroin 4. Marijuana 5. Nicotine 6. Phencyclidine XIII. Resources 1. LactMed 1. https://toxnet.nlm.nih.gov/newtoxnet/lactmed.htm 2. InfantRisk 1. https://www.infantrisk.com/ XIV. References 1. (2000) Harriet Lane Handbook, Mosby, p. 913 2. Hale

, chlorthalidone, methazolamide, and spironolactone.Hypoglycemic agents include chlorpropamide and tolbutamide.Antimalarial drugs include amodiaquine, dapsone, hydroxychloroquine, pyrimethamine, and quinine.Miscellaneous drugs include allopurinol, colchicine, aminoglutethimide, famotidine, bezafibrate, flutamide, tamoxifen, penicillamine, retinoic acid, metoclopramide, phenindione, dinitrophenol, ethacrynic acid

, chlorthalidone, methazolamide, and spironolactone.Hypoglycemic agents include chlorpropamide and tolbutamide.Antimalarial drugs include amodiaquine, dapsone, hydroxychloroquine, pyrimethamine, and quinine.Miscellaneous drugs include allopurinol, colchicine, aminoglutethimide, famotidine, bezafibrate, flutamide, tamoxifen, penicillamine, retinoic acid, metoclopramide, phenindione, dinitrophenol, ethacrynic acid

, chlorthalidone, methazolamide, and spironolactone.Hypoglycemic agents include chlorpropamide and tolbutamide.Antimalarial drugs include amodiaquine, dapsone, hydroxychloroquine, pyrimethamine, and quinine.Miscellaneous drugs include allopurinol, colchicine, aminoglutethimide, famotidine, bezafibrate, flutamide, tamoxifen, penicillamine, retinoic acid, metoclopramide, phenindione, dinitrophenol, ethacrynic acid

, chlorthalidone, methazolamide, and spironolactone.Hypoglycemic agents include chlorpropamide and tolbutamide.Antimalarial drugs include amodiaquine, dapsone, hydroxychloroquine, pyrimethamine, and quinine.Miscellaneous drugs include allopurinol, colchicine, aminoglutethimide, famotidine, bezafibrate, flutamide, tamoxifen, penicillamine, retinoic acid, metoclopramide, phenindione, dinitrophenol, ethacrynic acid

, chlorthalidone, methazolamide, and spironolactone.Hypoglycemic agents include chlorpropamide and tolbutamide.Antimalarial drugs include amodiaquine, dapsone, hydroxychloroquine, pyrimethamine, and quinine.Miscellaneous drugs include allopurinol, colchicine, aminoglutethimide, famotidine, bezafibrate, flutamide, tamoxifen, penicillamine, retinoic acid, metoclopramide, phenindione, dinitrophenol, ethacrynic acid

, chlorthalidone, methazolamide, and spironolactone.Hypoglycemic agents include chlorpropamide and tolbutamide.Antimalarial drugs include amodiaquine, dapsone, hydroxychloroquine, pyrimethamine, and quinine.Miscellaneous drugs include allopurinol, colchicine, aminoglutethimide, famotidine, bezafibrate, flutamide, tamoxifen, penicillamine, retinoic acid, metoclopramide, phenindione, dinitrophenol, ethacrynic acid