"Phenoxybenzamine"

Rupture of pheochromocytoma caused by phenoxybenzamine - A case report

Pheochromocytoma: a review on preoperative treatment with phenoxybenzamine or doxazosin. During surgical treatment of pheochromocytoma,`haemodynamic instability may occur. To prevent this, patients receive preoperative treatment with an alpha-blocker. Nowadays, some centres use phenoxybenzamine, while others use doxazosin. The purpose of this review is to analyse the current evidence of the benefits and risks of phenoxybenzamine and doxazosin in the preoperative treatment of pheochromocytoma. The literature was reviewed by searching PubMed using the following search terms: pheochromocytoma, phenoxybenzamine, doxazosin and alpha-blockade. The filter was set on English language. No randomised controlled trials were found. Five follow-up studies comparing phenoxybenzamine and doxazosin

Prospective Study to Compare Peri-operative Hemodynamic Alterations following Preparation for Pheochromocytoma Surgery by Phenoxybenzamine or Prazosin. Prospective studies comparing the efficacy of selective versus nonselective alpha blockers for preoperative preparation of pheochromocytoma (PCC) are lacking. In this prospective nonrandomized study, we compared the outcome of preoperative preparation with phenoxybenzamine (PBZ) and prazosin (PRZ) in terms of perioperative hemodynamic alterations. The study was conducted at a tertiary referral center from July 2010 to December 2012. Thirty-two patients with PCC underwent operation after adequate preparation with PBZ (n = 15) or PRZ (n = 17). Five pediatric and adolescent patients were excluded because of different hemodynamics

therapy for hypertension (phenoxybenzamine, phentolamine, alpha-blockers) and surgical excision of tumour (open or laparoscopic adrenalectomy). For unresectable tumours, alternative approaches include chemotherapy or radiopharmaceuticals.Complications include hypertensive crisis, myocardial infarction, and hypotension.DefinitionA tumour arising from catecholamine-producing chromaffin cells

) such as Bethanecol (10-20mg tds) to enhance detrusor tone with an alpha adrenergic blocker such as Phenoxybenzamine (10-20mg bd) or Prazosin (0.5-2mg bd) to reduce internal sphincter spasm and/or a muscle relaxant such as Baclofen (10-25mg qid) or Diazepam (2.5-5mg bd or tds) or botulinum toxin may be required. In addition, a sphincterotomy or urethral wall stent may also be required to help manage detrusor medications (e.g. Phenoxybenzamine, Prazosin).• Spasmolytic agents (e.g. Baclofen, Diazepam, Botulinum toxin injection).• Local anaesthetic (Xylocaine gel per urethra).• External sphincterotomy/urethral wall stent.• Prostatectomy/urethrotomy (for mechanical causes such as benign prostatic hypertrophy or urethral stricture).TABLE 3 – A summary of pharmacological and non-pharmacological options to manage

, including direct instrumentation of the tumor (e.g., fine-needle aspiration).Eating foods high in tyramine (e.g., red wine, chocolate, and cheese).Urination (e.g., bladder wall tumor, which is rare).Phenoxybenzamine (an alpha-adrenergic receptor blocker) is an effective treatment for catecholamine excess and metyrosine (a catecholamine synthesis antagonist) can be added if needed.Parasympathetic extra . Complications may include the following:Hypertensive crisis.Arrhythmia.Myocardial infarction.Pulmonary edema.Phenoxybenzamine (a nonselective alpha-antagonist) is the usual drug of choice; prazosin, terazosin, and doxazosin (selective alpha-1-antagonists) are alternative choices.[1,2] Prazosin, terazosin, and doxazosin are shorter acting than phenoxybenzamine, and therefore, the duration of postoperative

recommended? 3. In patients with an adrenal metastasis, does resection improve survival compared with systemic therapy alone? 6. Pheochromocytoma and paraganglioma 1. In patients with pheochromocytoma and paraganglioma, how does selective α blockade affect perioperative hemodynamic stability when compared with nonselective blockade with phenoxybenzamine or mortality between selective and nonselective α blockade, selective blockade (doxazosin, prazosin, terazosin) is associated with more intraoperative hemodynamic instability while nonselective blockade (phenoxybenzamine) results in more postoperative hypotension. (Strong recommendation, moderate-quality evidence.)Pheochromocytomas (PCCs) and paragangliomas (PGLs) have the highest heritability of all adrenal

and the nonselective alpha-blocker phenoxybenzamine were not reviewed in the course of this Guideline revision, the 2003 Guideline statement indicating that the data were insufficient to support a recommendation for the use of these two agents as treatment alternatives for LUTS secondary to BPH has been maintained.[Based on Panel consensus.]Alpha-blockers are a widely used class of medications for the treatment

by increased levels of urine and serum catecholamines, metanephrines, and normetanephrines.Treatment includes medical therapy for hypertension (phenoxybenzamine, phentolamine, alpha-blockers) and surgical excision of tumour (open or laparoscopic adrenalectomy). For unresectable tumours, alternative approaches include chemotherapy or radiopharmaceuticals.Complications include hypertensive crisis, myocardial

of 42 years were found to have malignant PPGLs. The mean size of the tumors were 5.4 cm, with 4 located in the paraaortic area and 1 in right adrenal. Functional imaging with Ga-DOTATATE PET/CT showed a mean SUV of 4.5. Four of 5 patients underwent open resection of the tumors under general anesthesia following preoperative alpha blockade with oral phenoxybenzamine. The mean PASS score of the excised

, and two echocardiographic examinations led to the diagnosis of TTS. When the patient was treated by phenoxybenzamine instead of surgery for the PGL, his blood pressure and glucose level gradually returned to normal. The CAE was treated by thrombolysis, antiplatelet medications, atorvastatin, and myocardial protection therapies. No symptoms of PGL, CAE, or TTS were seen during a 6-month follow-up , and the patient had an excellent quality of life. We confirmed that phenoxybenzamine was the cause of the TTS because paradoxical systolic motion of the apex, inferior wall, left ventricular anterior wall, and interventricular septum were similarly recovered when the PGL was treated by phenoxybenzamine. To raise awareness of this illness and prevent misdiagnosis, we have herein presented a case of TTS