PiliAnnulati. This case report describes a teenage girl with glistening hair and was found to have alternating dark and light bands within the hair shafts on trichoscopic evaluation.
Piliannulati with fragility: Electron microscopic findings of a case Piliannulati (PA) is typically characterized by shinny beads seen along the hair shaft. PA is accepted to belong to the classification of hair shaft abnormalities without fragility. Herein, we described a 14-year-old, fair skin with dark-haired girl diagnosed as PA with fragility which was demonstrated by weathering features
trichorrhexis nodosa. Role of cumulative damage in frayed hair. Arch Dermatol. 1972 Dec. 106(6):888-92. [QxMD MEDLINE Link]. 10. Marubashi Y, Yanagishita T, Muto J, Taguchi N, Sugiura K, Kawamoto Y, et al. Morphological analyses in fragility of pili torti with Björnstad syndrome. J Dermatol. 2017 Apr. 44 (4):455-458. [QxMD MEDLINE Link]. 11. Gonzalez AM, Borda LJ, Tosti A. PiliAnnulati
trichorrhexis nodosa. Role of cumulative damage in frayed hair. Arch Dermatol. 1972 Dec. 106(6):888-92. [QxMD MEDLINE Link]. 10. Marubashi Y, Yanagishita T, Muto J, Taguchi N, Sugiura K, Kawamoto Y, et al. Morphological analyses in fragility of pili torti with Björnstad syndrome. J Dermatol. 2017 Apr. 44 (4):455-458. [QxMD MEDLINE Link]. 11. Gonzalez AM, Borda LJ, Tosti A. PiliAnnulati
trichorrhexis nodosa. Role of cumulative damage in frayed hair. Arch Dermatol. 1972 Dec. 106(6):888-92. [QxMD MEDLINE Link]. 10. Marubashi Y, Yanagishita T, Muto J, Taguchi N, Sugiura K, Kawamoto Y, et al. Morphological analyses in fragility of pili torti with Björnstad syndrome. J Dermatol. 2017 Apr. 44 (4):455-458. [QxMD MEDLINE Link]. 11. Gonzalez AM, Borda LJ, Tosti A. PiliAnnulati
trichorrhexis nodosa. Role of cumulative damage in frayed hair. Arch Dermatol. 1972 Dec. 106(6):888-92. [QxMD MEDLINE Link]. 10. Marubashi Y, Yanagishita T, Muto J, Taguchi N, Sugiura K, Kawamoto Y, et al. Morphological analyses in fragility of pili torti with Björnstad syndrome. J Dermatol. 2017 Apr. 44 (4):455-458. [QxMD MEDLINE Link]. 11. Gonzalez AM, Borda LJ, Tosti A. PiliAnnulati
Cytokeratin expression in piliannulati hair follicles. Piliannulati is a rare autosomal inherited hair shaft abnormality of unknown pathogenesis in which clinical examination reveals alternating light and dark bands leading to a shiny appearance of the hair due to cavities within the cortex of the hair shaft. This is the first investigation of the proposed cytokeratin defect in piliannulati hair follicles. Four cryopreserved piliannulati and four control scalp specimens were analysed using immunohistochemistry for different 'hard' trichocytic and 'soft' epithelial cytokeratins including K1, K6, K10, K14, K16, K17, K18, K19, Ha1 and Hb1. There was no difference in staining intensity and quality of staining pattern seen in piliannulati and control scalp specimens. These results suggest
Alterations in the basement membrane zone in piliannulati hair follicles as demonstrated by electron microscopy and immunohistochemistry. Piliannulati is a rare autosomal dominant inherited hair shaft abnormality in which clinical examination reveals alternating light and dark bands leading to a shiny appearance of the hair. The clinically light bands are the abnormal areas due to cavities within the cortex. The pathogenesis remains unknown. To investigate the expression of the basement membrane zone (BMZ) components in piliannulati hair follicles of the scalp. Transmission electron microscopy (TEM) was carried out on scalp sections of six individuals with piliannulati and six controls. Longitudinal sections of scalp tissues from four individuals with piliannulati and six normal
Disappearance of piliannulati following an episode of alopecia areata. Piliannulati is a distinctive autosomal dominant hair shaft disorder that produces alternating light and dark bands that can give a spangled appearance to the hair. The literature contains three case reports of patients in whom the condition has disappeared following recovery from alopecia totalis. None of these reports contain a direct microscopic comparison of pre- and post-regrowth hairs. We report a 6-year-old girl who was first noted to have piliannulati at the age of 2 years and who developed alopecia totalis at the age of 3 years. When the hair regrew spontaneously, 18 months later, the piliannulati was no longer visible. Hair samples obtained before and after the episode of alopecia areata were compared
Phenotypes of the ovarian follicular basal lamina predict developmental competence of oocytes. The ovarian follicular basal lamina underlies the epithelial membrana granulosa and maintains the avascular intra-follicular compartment. Additional layers of basal lamina occur in a number of pathologies, including piliannulati and diabetes. We previously found additional layers of follicular basal
Piliannulati: refinement of the locus on chromosome 12q24.33 to a 2.9-Mb interval and candidate gene analysis. Piliannulati is an autosomal dominant hair shaft disorder characterized by alternating light and dark bands in hairs of affected individuals. Recently, a locus for piliannulati was mapped to chromosome 12q24.32-24.33 and recombination events defined a critical region of 9.2 cM (3.9 Mb). The aim of the current study was to narrow the size of the candidate region and to identify the pathogenic mutation for piliannulati by analysing the candidate genes. In three families with 90 individuals, including 40 affected subjects, linkage analysis was performed with 13 microsatellite markers in the candidate region on chromosome 12. Candidate genes were analysed for their expression
-shaft characteristics were photographed using a digital camera. Dermatoscopy was helpful in detecting tapered hairs, weathering, monilethrix, pediculosis capitis, peripilar casts, 'exclamation-mark' hairs of alopecia areata, bubble hair and pili torti. It was less helpful in piliannulati and unhelpful in detecting 'tiger-tail' banding in trichothiodystrophy. Light microscopy provided greater detail in almost all cases; it was necessary for detection of cuticle changes and added significant information in detecting characteristic features of trichothiodystrophy, piliannulati, bubble hair and pili torti. Dermatoscopy is most revealing in conditions resulting in gross changes in shaft outline and colour, where reflected light is valuable. It is unhelpful for detection of features within the shaft
Concomitant Manifestation of PiliAnnulati and Alopecia Areata: Coincidental Rather than True Association. The autosomal dominantly inherited hair disorder piliannulati is characterized by alternating light and dark bands of the hair shaft. Concomitant manifestation of piliannulati with alopecia areata has been reported previously on several occasions. However, no systematic evaluation of patients manifesting both diseases has been performed. We studied the simultaneous or sequential occurrence of piliannulati and alopecia areata in individuals diagnosed in different European academic dermatology units. We included 162 Caucasian individuals from 14 extended families, comprising 76 affected and 86 unaffected family members. Statistical analysis showed that the frequency of alopecia areata
A gene locus responsible for the familial hair shaft abnormality piliannulati maps to chromosome 12q24.32-24.33. Piliannulati, a rare hair shaft abnormality with a characteristic shiny appearance due to alternating light and dark bands of the hair, is assumed to be inherited in an autosomal dominant mode with high penetrance. A locus for piliannulati has not been found yet. We identified one large and four small European kindreds with piliannulati and conducted a genomewide linkage analysis using 382 microsatellite markers. A multipoint logarithm of the odds (LOD) score of 3.19 was demonstrated between D12S1659 and D12S1723 on the telomeric part of the long arm of chromosome 12. Subsequent finemapping in a region of 20 cM gave a maximum multipoint LOD score of 3.24 at D12S1723 under
A gene for piliannulati maps to the telomeric region of chromosome 12q. Piliannulati (PA) is a rare hair shaft disorder characterized by discrete banding of hairs. We studied two families with PA in which the disorder segregated in an autosomal dominant fashion. All family members were clinically examined and hair samples were examined under the light microscope. In family G, of 19 individuals