in the outer membrane. The conversion of the 42-kDal precursor to M2 is inhibited by a number of different local anesthetics (procaine, piperocaine, lidocaine, cocaine), by the neuroactive drug atropine, and by the classical trypsin inhibitors N alpha-tosyllysine chloromethyl ketone (TLCK) and benzamidine. Our kinetic studies demonstrate that the amidase action of pure trypsin is inhibited competitively
, and toes (due to constriction of end arteries), is invalidated, since no case of necrosis has been reported since the introduction of commercial lidocaine with epinephrine in 1948.[58]Ester group[edit]Procaine * Benzocaine * Chloroprocaine * Cocaine * Cyclomethycaine * Dimethocaine (Larocaine) * Piperocaine * Propoxycaine * Procaine (Novocaine) * Proparacaine * Tetracaine (Amethocaine)Amide group[edit