Opportunistic Infection Therapeutic Guidelines - Pneumocystispneumonia (PCP) 2 TABLE OF CONTENTS I) PROPHYLAXIS ................................................................................................................................ 3 A) INDICATIONS .................................................................................................................................. 3 B , polymerase chain reaction; PLWH, persons living with HIV; TMP-SMX, trimethoprim-sulfamethoxazole PNEUMOCYSTISPNEUMONIA (PCP) 3 I) PROPHYLAXIS Recommendations: a) Indications: i) Primary prophylaxis is recommended for patients with either a CD4 count below 200 cells/μL (AI) or a CD4 fraction below 14% (BII), and considered if the CD4 is 200-250 cells/μL and follow-up is uncertain (BII) ii) Secondary
CRISPR-mediated detection of Pneumocystis transcripts in bronchoalveolar, oropharyngeal, and serum specimens for Pneumocystispneumonia diagnosis. Pneumocystis jirovecii pneumonia (PCP) is a leading cause of fungal pneumonia, but its diagnosis primarily relies on invasive bronchoalveolar lavage (BAL) specimens that are difficult to obtain. Oropharyngeal swabs and serum could improve the PCP
Pneumocystispneumonia in intensive care: clinical spectrum, prophylaxis patterns, antibiotic treatment delay impact, and role of corticosteroids. A French multicentre prospective cohort study. Severe Pneumocystis jirovecii pneumonia (PJP) requiring intensive care has been the subject of few prospective studies. It is unclear whether delayed curative antibiotic therapy may impact survival
Effectiveness of pulse methylprednisolone in patients with non-human immunodeficiency virus pneumocystispneumonia: a multicentre, retrospective registry-based cohort study. A recent database study and meta-analysis reported that adjunctive glucocorticoid therapy reduces mortality in patients with non-human immunodeficiency virus-associated (non-HIV) Pneumocystis jirovecii pneumonia (PCP
Use of echinocandins combined with clindamycin in Pneumocystispneumonia: a case series of 14 patients. Pneumocystis jirovecii pneumonia (PcP) is an opportunistic infection for which the standard of care is co-trimoxazole. However, safety concerns and intolerance may compromise its utility. To evaluate the safety and efficacy of the combination of echinocandins and clindamycin to treat PcP. We
Should HIV-uninfected patients with Pneumocystispneumonia be treated with corticosteroids? Chiefs’ Inquiry Corner – March 17th, 2019 – Clinical Correlations Clinical Correlations * AboutAboutAwardsPeer Review * CategoriesBedside RoundsChiefs' Inquiry CornerCORE IM PodcastDiseases 2.0EthicsEvolution and MedicineGamechanger?Healthcare PolicyHotSpotsMystery QuizMyths that vaccination poses, and the tremendous importance of influenza primary prevention each season, the risk of GBS is best placed secondary to the task of primary influenza prevention.References: Influenza and GBS Tisch/Kimmel: Should HIV-uninfected patients with Pneumocystispneumonia be treated with corticosteroids? Pneumocystis jirovecii (previously carinii) has long been known to cause pulmonary disease
Relationship between clinical features and droplet digital PCR copy number in non-HIV patients with pneumocystispneumonia. Droplet digital PCR (ddPCR) is a novel assay to detect pneumocystis jjrovecii (Pj) which has been defined to be more sensitive than qPCR in recent studies. We aimed to explore whether clinical features of pneumocystispneumonia (PCP) were associated with ddPCR copy numbers
Low- Versus Conventional-Dose Trimethoprim-Sulfamethoxazole Treatment for PneumocystisPneumonia in Non-Human Immunodeficiency Virus-Infected Patients: A Multi-Center, Retrospective Observational Cohort Study. Trimethoprim-sulfamethoxazole (TMP-SMX) is an effective treatment for Pneumocystis jirovecii pneumonia (PCP) in immunocompromised patients with and without human immunodeficiency virus
Non-small cell lung cancer with bone metastasis and pneumocystispneumonia in a pregnant woman: a case report and literature review. Cancer case during pregnancy is rare, but it is the second leading cause of maternal mortality. A-32-year old pregnant woman with a gestational age of 37 weeks was admitted to the hospital due to repeated coughing for 5 months. She received Veno-Venous Extracorporeal Membrane Oxygenation (V-V ECMO) treatment for severe hypoxemia after delivery. She was diagnosed with non-small cell lung cancer (NSCLC) with bone metastasis and pneumocystispneumonia (PCP). She subsequently received anti-tumor therapy and anti-infective therapy. After treatment, her condition improved and she was weaned from ECMO. Two weeks after weaning ECMO, her condition worsened again. Her
Risk factors for Pneumocystispneumonia with acute respiratory failure among kidney transplant recipients. One of the rare life-threatening fungal infections is pneumocystispneumonia (PCP). Immunocompromised patients are the main vulnerable population. We investigate the risk factors associated with the development of severe PCP infection with acute respiratory failure after kidney
Rising Incidence of Pneumocystispneumonia: a population-level descriptive ecological study in England. Pneumocystispneumonia (PCP) is an opportunistic infection that causes significant morbidity and mortality in the immunocompromised population. This population is growing and diversifying, yet contemporary epidemiology is lacking. We investigated the population-level incidence of PCP over
Role of fungal burden in risk stratification of non-HIV patients with Pneumocystispneumonia: A 12-year retrospective observational multicenter cohort. Explore the role of fungal burden in risk stratification of non-HIV patients with Pneumocystispneumonia (PCP). Retrospective analysis of characteristics associated with 30-day mortality in patients with positive P. jirovecii PCR in BALF between
Clinical features and prognostic predictors in patients with rheumatic diseases complicated by Pneumocystispneumonia. To investigate the clinical outcomes and risk factors of mortality in patients with rheumatic diseases complicated by Pneumocystispneumonia (PCP). Between November 2015 and April 2021, patients with rheumatic diseases with PCP in a tertiary referral hospital were
Initiating antiretroviral therapy within 2 weeks of anti-Pneumocystis treatment does not increase mortality or AIDS-defining events in patients with HIV-associated moderate to severe Pneumocystispneumonia: results of a prospective observational multicen The mortality rate remains high among patients with coinfection with Pneumocystispneumonia (PCP) and HIV. The timing for initiation
Extracorporeal membrane oxygenation rescue for severe pneumocystispneumonia with the Macklin effect: a case report. Pneumocystis jirovecii pneumonia (PJP) in an immunocompromised host is often associated with the Macklin effect, which can progress to spontaneous pneumomediastinum (SPM), subcutaneous emphysema (SCE), and pneumothorax (PNX). Diagnosing the causative organism of these conditions
Spotlight: PneumocystisPneumonia in a Patient Without AIDS, A Clinical Vignette Spotlight: PneumocystisPneumonia in a Patient Without AIDS, A Clinical Vignette – Clinical Correlations Clinical Correlations * AboutAboutAwardsPeer Review * CategoriesBedside RoundsChiefs' Inquiry CornerCORE IM PodcastDiseases 2.0EthicsEvolution and MedicineGamechanger?Healthcare PolicyHotSpotsMystery QuizMyths and RealitiesPrimeCutsSpotlightSee All Categories * SystemsAllergy/ImmunologyCardiologyDermatologyEndocrineGeriatricsGIHeme/OncIDMusculoskeletalNeuroNutritionPain/PalliativePsychiatryPulmonary/Critical CareRadiologyRenalRheumatologyUrology * SubscribeSearch Spotlight: PneumocystisPneumonia in a Patient Without AIDS, A Clinical VignetteSeptember 20, 2017ID Pulmonary/Critical Care Spotlight 6 min read | Twitter | Facebook
Identifying predictors for bacterial and fungal coinfection on chest computed tomography in patients with Pneumocystispneumonia. Pneumocystispneumonia (PCP) is a common opportunistic infection with high mortality in individuals with decreased immunity. Pulmonary coinfections with PCP are associated with poor prognosis. The study aims to identify radiological predictors for pulmonary
T and B cell abnormalities, pneumocystispneumonia, and chronic lymphocytic leukemia associated with an AIOLOS defect in patients. AIOLOS/IKZF3 is a member of the IKAROS family of transcription factors. IKAROS/IKZF1 mutations have been previously associated with different forms of primary immunodeficiency. Here we describe a novel combined immunodeficiency due to an IKZF3 mutation in a family
Toward a humanized mouse model of Pneumocystispneumonia. Pneumocystis is an important opportunistic fungus that causes pneumonia in children and immunocompromised individuals. Recent genomic data show that divergence of major surface glycoproteins may confer speciation and host range selectivity. On the other hand, immune clearance between mice and humans is well correlated. Thus, we recognition of trophs (CD209) and asci (CLEC7A). These same genes were downregulated in CD4-deficient mice as well as twins with bare lymphocyte syndrome with Pneumocystispneumonia.
Differences and similarities of high-resolution computed tomography features between pneumocystispneumonia and cytomegalovirus pneumonia in AIDS patients. Accurately differentiating pneumocystis from cytomegalovirus pneumonia is crucial for correct therapy selection in AIDS patients. Hence, the goal of this study was to compare the computerized tomography (CT) features of pneumocystispneumonia and cytomegalovirus pneumonia in AIDS patients and identify clinical hallmarks to accurately distinguish these two pathologies. A total of 112 AIDS patients (78 with pneumocystispneumonia and 34 cytomegalovirus pneumonia) at Beijing Ditan Hospital from January 2017 to May 2019 were included in this study. Two experienced chest radiologists retrospectively reviewed CT images for 17 features including ground-glass