Spotlight: what are the clinical implications of prominent trabeculation: cardiomyopathy or normal variant? Spotlight: What are the Clinical Implications of Prominent Trabeculation: Cardiomyopathy or Normal Variant? – Clinical Correlations Clinical Correlations * AboutAboutAwardsPeer Review * CategoriesBedside RoundsChiefs' Inquiry CornerCORE IM PodcastDiseases 2.0EthicsEvolution and MedicineGamechanger?Healthcare PolicyHotSpotsMystery QuizMyths and RealitiesPrimeCutsSpotlightSee All Categories * SystemsAllergy/ImmunologyCardiologyDermatologyEndocrineGeriatricsGIHeme/OncIDMusculoskeletalNeuroNutritionPain/PalliativePsychiatryPulmonary/Critical CareRadiologyRenalRheumatologyUrology * SubscribeSearch Spotlight: What are the Clinical Implications of Prominent Trabeculation: Cardiomyopathy
Effect size reporting among prominent health journals: a case study of odds ratios Effect size reporting among prominent health journals: a case study of odds ratios ================================================================================== * Brian Chu * Michael Liu * Eric C Leas * Benjamin M Althouse * John W Ayers ## Abstract **Background** The accuracy of statistical reporting that informs medical and public health practice has generated extensive debate, but no studies have evaluated the frequency or accuracy of effect size (the magnitude of change in outcome as a function of change in predictor) reporting in prominent health journals. **Objective** To evaluate effect size reporting practices in prominent health journals using the case study of ORs. **Design** Articles published
Boosting or inhibiting - how semantic-pragmatic and syntactic cues affect prosodic prominence relations in German. In this exploratory study, we investigate the influence of several semantic-pragmatic and syntactic factors on prosodic prominence production in German, namely referential and lexical newness/givenness, grammatical role, and position of a referential target word within a sentence . Especially in terms of the probabilistic distribution of accent status (nuclear, prenuclear, deaccentuation) we find evidence for an additive influence of the discourse-related and syntactic cues, with lexical newness and initial sentence position showing the strongest boosting effects on a target word's prosodic prominence. The relative strength of the initial position is found in nearly all prosodic
Endorsements of five reporting guidelines for biomedical research by journals of prominent publishers. Biomedical research reporting guidelines provide a framework by which journal editors and the researchers who conduct studies can ensure that the reported research is both complete and transparent. With more than 16 different guidelines for the 11 major study types of medical and health research , authors need to be familiar with journal reporting standards. To assess the current endorsements of reporting guidelines for biomedical and health research, this study examined the instructions for authors (IFAs) of 559 biomedical journals by 11 prominent publishers that publish original research or systematic reviews/meta-analyses. Data from the above original sources were cleaned and restructured
Prosody matters: Preserved prominence marking strategies in people with Parkinson's disease independent of motor status. While many studies focus on segmental variation in Parkinsonian speech, little is known about prosodic modulations reflecting the ability to adapt to communicative demands in people with Parkinson's disease (PwPD). This type of prosodic modulation is important for social of the oral articulators: tongue tip movements were smaller and lower lip movements were larger in amplitude under levodopa, reflecting a more agile and efficient articulatory movement under levodopa. Thus, respiratory-phonatory functions and consonant production improved, while syllable duration and tongue body kinematics did not change. Interestingly, prominence marking strategies were comparable between
Pollution and health risk assessments related to heavy metals on three prominent beaches in Makkah Province, Kingdom of Saudi Arabia: Concerning levels of cadmium pollution. Beach pollution can impact the health of people living in or visiting coastal areas. The primary goal of this research was to investigate the presence of heavy metal pollutants and associated health risks in three distinct
Detecting changes in tobacco product marketplace prominence using social media, advertising, sales, and web traffic data: The example of Puff Bar in the United States tobacco marketplace from 2019 to 2021. Puff Bar, a disposable electronic nicotine delivery system (ENDS), was the ENDS brand most commonly used by U.S. youth in 2021. We explored whether Puff Bar's rise in marketplace prominence ), and the number of visits to the Puff Bar website (web traffic) exhibited potential for surveilling Puff Bar due to ease of calculation, comprehensibility, and responsiveness to events. Advertising tracked through Numerator and Comperemedia did not appear to capture marketing from Puff Bar's manufacturer or drive change in marketplace prominence. This study demonstrates how quantitative changes in metrics
Heterogeneity of Primary Outcomes in Large Atherosclerotic Cardiovascular Disease Trials Published in Prominent Medical Journals. This cohort study examines heterogeneity in primary end points reported by randomized clinical trials of atherosclerotic cardiovascular disease published in prominent medical journals.
Effectiveness of supracondylar dome osteotomy in reducing lateral condylar prominence and enhancing functional outcomes in pediatric cubitus varus: a retrospective study. Cubitus varus, a common complication of pediatric supracondylar humerus fractures, presents with internal rotation, extension, and varus angulation. While primarily considered a cosmetic concern, it can lead to significant complications, including chronic pain, ulnar nerve palsy, and posterolateral elbow instability. This study evaluates the effectiveness of supracondylar dome osteotomy in decreasing lateral condylar prominence and improving functional outcomes in patients with cubitus varus. This retrospective cohort study analyzed 65 patients under 18 who underwent dome-shaped corrective osteotomy between 2017 and 2022
NLRP1 Is a Prominent Inflammasome Sensor Found in Bronchial Epithelial Cells in Asthma and Can Be Activated by Rhinovirus A16. Asthma exacerbations are frequently triggered by human rhinoviruses (RVs). Among other pro-inflammatory responses, RV infection of airway epithelium promotes the activation of the inflammasome pathway, the role of which in asthma exacerbations and disease progression
Mutations in the small nuclear RNA gene RNU2-2 cause a severe neurodevelopmental disorder with prominent epilepsy. The major spliceosome includes five small nuclear RNA (snRNAs), U1, U2, U4, U5 and U6, each of which is encoded by multiple genes. We recently showed that mutations in RNU4-2, the gene that encodes the U4-2 snRNA, cause one of the most prevalent monogenic neurodevelopmental disorders
Greater nurse density correlates to higher level of population ageing globally, but is more prominent in developed countries. Representing over 50% of the healthcare workforce, nurses provide care to people at all ages. This study advances, at a population level, that high levels of nursing services, measured by nurse density may significantly promote population ageing measured by the percentage . The universal correlations identified in country groupings suggest that low nurse density may be a significant global concern. While nurse density might contribute significantly to 65yo% globally, the effect was more prominent in developed countries. Ironically, countries with higher nurse densities and therefore greater levels of 65yo%, were countries with an increased need for more nursing staff
Evaluation of open-face maxillary complete denture for patients with prominent premaxilla: a crossover study. The establishment of good facial esthetics is one of the main objectives of complete denture construction. Unfortunately, it may be the caused issue for patients having a prominent premaxilla due to excessive lip support by the labial flange of the maxillary denture. Open-face dentures (OFD) may suggest suitable prosthetic management for these patients. However, clinical evidence regarding the efficiency of OFD is scarce. A total of 38 completely edentulous participants having prominent premaxilla and skeletal class I Angle's classification were enrolled in this study. Each participant received a mandibular complete denture and 2 opposing maxillary dentures; conventional (CD
Prominent role of gut dysbiosis in the pathogenesis of cystic fibrosis-related liver disease in mice. Cystic fibrosis-related liver disease (CFLD) is a chronic cholangiopathy that increases morbidity and mortality in patients with CF. Current treatments are unsatisfactory, and incomplete understanding of CFLD pathogenesis hampers therapeutic development. We have previously shown that mouse CF
De novo FRMD5 Missense Variants in Patients with Childhood-Onset Ataxia, Prominent Nystagmus, and Seizures. FRMD5 variants were recently identified in patients with developmental delay, ataxia, and eye movement abnormalities. We describe 2 patients presenting with childhood-onset ataxia, nystagmus, and seizures carrying pathogenic de novo FRMD5 variants. Weighted gene co-expression network
Microbiological isolates and associated complications of dacryocystitis and canaliculitis in a prominent tertiary ophthalmic teaching hospital in northern China. To report the microbiological isolates, aetiology, complications, antibiotic susceptibilities, and clinical remission of dacryocystitis and canaliculitis in a prominent tertiary ophthalmic teaching and referral hospital located
Heterozygous THBS2 pathogenic variant causes Ehlers-Danlos syndrome with prominent vascular features in humans and mice. Ehlers-Danlos syndromes (EDS) are a group of connective tissue disorders caused by mutations in collagen and collagen-interacting genes. We delineate a novel form of EDS with vascular features through clinical and histopathological phenotyping and genetic studies of a three
Hypertension as a prominent manifestation secondary to renal artery lesions in pediatric Behcet's disease. Hypertension caused by vascular Behcet's disease (BD) is an important prognostic factor of paediatric BD. However, much less is known about its clinical features. The objective of this study was to investigate the clinical characteristics of paediatric vascular BD complicated