Association of Sleep Spindle Rate With Memory Consolidation in Children With RolandicEpilepsy. Rolandicepilepsy (RE), the most common childhood focal epilepsy syndrome, is characterized by a transient period of sleep-activated epileptiform activity in the centrotemporal regions and variable cognitive deficits. Sleep spindles are prominent thalamocortical brain oscillations during sleep
Perforating artery injury as a critical factor besides cortical dysfunction in motor deficit after peri-rolandicepilepsy surgery. Surgery for peri-rolandicepilepsy requires appropriate consideration to balance the functional risk of postoperative motor deficit and seizure outcome. Based on voxel-based morphometric analysis, the authors hypothesized that cortical damage and ischemic subcortical damage related to surgery could affect postoperative motor deterioration. Sixteen patients with peri-rolandicepilepsy who underwent resective surgery at a single institution were retrospectively investigated. Their imaging findings, postoperative seizure outcomes, and postoperative neurological deteriorations in motor function, as well as duration, were analyzed. Using the standardized MRI data
Changing Agendas on Sleep, Treatment and Learning in Epilepsy (CASTLE) Sleep-E: a protocol for a randomised controlled trial comparing an online behavioural sleep intervention with standard care in children with Rolandicepilepsy. Sleep and epilepsy have an established bidirectional relationship yet only one randomised controlled clinical trial has assessed the effectiveness of behavioural sleep interventions for children with epilepsy. The intervention was successful, but was delivered via face-to-face educational sessions with parents, which are costly and non-scalable to population level. The Changing Agendas on Sleep, Treatment and Learning in Epilepsy (CASTLE) Sleep-E trial addresses this problem by comparing clinical and cost-effectiveness in children with Rolandicepilepsy between standard
Delayed brain development of Rolandicepilepsy profiled by deep learning-based neuroanatomic imaging. Although Rolandicepilepsy (RE) has been regarded as a brain developmental disorder, neuroimaging studies have not yet ascertained whether RE has brain developmental delay. This study employed deep learning-based neuroanatomic biomarker to measure the changed feature of "brain age" in RE of attention. This study provided neuroimaging evidence to support the notion that RE has delayed brain development. • The children with Rolandicepilepsy showed imaging phenotypes of delayed brain development with increased GM volume and decreased WM volume in the Rolandic regions. • The children with Rolandicepilepsy had a 0.45-year delay of brain-predicted age by comparing with typically developing
Temporal trends in incidence of Rolandicepilepsy, prevalence of comorbidities and prescribing trends: birth cohort study. To examine temporal trends in incidence of Rolandicepilepsy (RE), prevalence of comorbidities and antiepileptic drug (AED) prescribing patterns. Retrospective cohort study. The UK. Children aged 0-16 years born 1994-2012 were followed from birth until September 2017
Stridor as initial presentation of rolandicepilepsy. The authors present the case of a 5-year-old girl referred to our institution due to several episodes of nocturnal stridor with ocular retroversion and parental notion of apnea. She has been previously submitted to adenotonsillectomy. Due to symptoms worsening she was referred to our hospital. Here, a nasal fiberoptic endoscopy evaluation
Identification of new risk factors for rolandicepilepsy: CNV at Xp22.31 and alterations at cholinergic synapses. Rolandicepilepsy (RE) is the most common genetic childhood epilepsy, consisting of focal, nocturnal seizures and frequent neurodevelopmental impairments in speech, language, literacy and attention. A complex genetic aetiology is presumed in most, with monogenic mutations
Exome-wide analysis of mutational burden in patients with typical and atypical Rolandicepilepsy. Rolandicepilepsy (RE) is the most common focal epilepsy in childhood. To date no hypothesis-free exome-wide mutational screen has been conducted for RE and atypical RE (ARE). Here we report on whole-exome sequencing of 194 unrelated patients with RE/ARE and 567 ethnically matched population controls
Tantrums, Emotion Reactions and Their EEG Correlates in Childhood Benign RolandicEpilepsy vs. Complex Partial Seizures: Exploratory Observations We explored associations between EEG pathophysiology and emotional/behavioral (E/B) problems of children with two types of epilepsy using standard parent questionnaires and two new indicators: tantrums recorded by parents at home and brief, emotion -eliciting situations in the laboratory. Children with Benign Rolandicepilepsy (BRE, = 6) reportedly had shorter, more angry tantrums from which they recovered quickly. Children with Complex Partial Seizures (CPS, = 13) had longer, sadder tantrums often followed by bad moods. More generally, BRE correlated with anger and aggression; CPS with sadness and withdrawal. Scores of a composite group
Benign Rolandicepilepsy presenting like paradoxical vocal fold motion. Paradoxical vocal fold motion (PVFM) is characterized by vocal fold adduction during respiration. Benign Rolandicepilepsy (BRE) is the most common childhood epilepsy and can cause oropharyngolaryngeal or facial manifestations. A 9-year-old male presented with intermittent apnea lasting 30-60 seconds and presumed PVFM
Reading comprehension difficulties in children with rolandicepilepsy. Difficulties in reading comprehension can arise from either word reading or listening comprehension difficulties, or a combination of the two. We sought to determine whether children with rolandicepilepsy had poor reading comprehension relative to typically developing comparison children, and whether such difficulties were associated with word reading and/or general language comprehension difficulties. In this cross-sectional study, children with rolandicepilepsy (n=25; 16 males, 9 females; mean age 9y 1mo, SD 1y 7mo) and a comparison group (n=39; 25 males, 14 females; mean age 9y 1mo, SD 1y 3mo) completed assessments of reading comprehension, listening comprehension, word/non-word reading, speech articulation, and Non
Identification of new risk factors for rolandicepilepsy: CNV at Xp22.31 and alterations at cholinergic synapses Identification of new risk factors for rolandicepilepsy: CNV at Xp22.31 and alterations at cholinergic synapses - JMG Contact blog Skip to content * Home * JournalIdentification of new risk factors for rolandicepilepsy: CNV at Xp22.31 and alterations at cholinergic synapsesPosted
Real-time effects of centrotemporal spikes on cognition in rolandicepilepsy: An EEG-fMRI study. To identify the real-time effects of interictal rolandic spikes (or centrotemporal spikes [CTS]) on language, behavior, and cognitive function in patients with rolandicepilepsy (RE). We studied 22 medication-naive patients with RE using EEG-fMRI with a 3T MRI scanner. We used simultaneous EEG
A microRNAâ€328 binding site in PAX6 is associated with centrotemporal spikes of rolandicepilepsyRolandicepilepsy is a common genetic focal epilepsy of childhood characterized by centrotemporal sharp waves on electroencephalogram. In previous genome-wide analysis, we had reported linkage of centrotemporal sharp waves to chromosome 11p13, and fine mapping with 44 SNPs identified the ELP4-PAX6 locus in two independent US and Canadian case-control samples. Here, we aimed to find a causative variant for centrotemporal sharp waves using a larger sample and higher resolution genotyping array. We fine-mapped the ELP4-PAX6 locus in 186 individuals from rolandicepilepsy families and 1000 population controls of European origin using the Illumina HumanCoreExome-12 v1.0 BeadChip. Controls were
Rare variants in GABAA receptor genes in Rolandicepilepsy and related syndromes. To test whether mutations in γ-aminobutyric acid type A receptor (GABAA -R) subunit genes contribute to the etiology of rolandicepilepsy (RE) or its atypical variants (ARE). We performed exome sequencing to compare the frequency of variants in 18 GABAA -R genes in 204 European patients with RE
Antiepileptic drug treatment of rolandicepilepsy and Panayiotopoulos syndrome: clinical practice survey and clinical trial feasibility. The evidence base for management of childhood epilepsy is poor, especially for the most common specific syndromes such as rolandicepilepsy (RE) and Panayiotopoulos syndrome (PS). Considerable international variation in management and controversy about non
Risk factors for reading disability in rolandicepilepsy families The high prevalence and impact of neurodevelopmental comorbidities in childhood epilepsy are now well known, as are the increased risks and familial aggregation of reading disability (RD) and speech sound disorder (SSD) in rolandicepilepsy (RE). The risk factors for RD in the general population include male sex, SSD, and ADHD