Vestibular schwannoma Skip to main contentSkip to searchAbout usHelpSubscribeAccess through your institutionLog inBMJ Best PracticeSearchSearchSelect languageVestibular schwannoma MENULog in or subscribe to access all of BMJ Best PracticeLast reviewed:20 Aug 2023Last updated:15 Sep 2023SummaryVestibular schwannoma is a histologically benign, generally slow-growing tumour that may remain stable ), and patient preference.DefinitionA vestibular schwannoma is a histologically benign, usually slow-growing tumour that develops from the vestibular divisions of the vestibulocochlear nerve, typically presenting with unilateral sensorineural hearing loss.[1][2] Vestibular schwannomas are also called acoustic neuromas; however, the term 'acoustic neuroma' is a misnomer because the tumour actually grows from
Assessment of stereotactic radiosurgery (SRS) for the treatment of vestibular schwannoma requiring intervention 1 Translation of Chapters 1 to 6 of the final report N20-03 Stereotaktische Radiochirurgie zur Behandlung von interventionsbedürftigen Vestibularisschwannomen (Version 1.0; Status: 20 September 2021 [German original], 19 January 2022 [English translation]). Please note: This document was translated by an external translator and is provided as a service by IQWiG to English-language readers. However, solely the German original text is absolutely authoritative and legally binding. Extract IQWiG Reports – Commission No. N20-03 Stereotactic radiosurgery for the treatment of vestibular schwannoma requiring intervention1 Extract of final
Improving access to vestibular schwannoma quality of life research through multilanguage translations of the Mayo Clinic Vestibular Schwannoma Quality of Life Index. To address the limitations of existing instruments, the authors developed the Vestibular Schwannoma Quality of Life (VSQOL) Index. The Index captures the multifaceted impacts of vestibular schwannoma (VS) on daily life across eight
Genetic profiling of rat gliomas and cardiac schwannomas from life-time radiofrequency radiation exposure study using a targeted next-generation sequencing gene panel. The cancer hazard associated with lifetime exposure to radiofrequency radiation (RFR) was examined in Sprague Dawley (SD) rats at the Ramazzini Institute (RI), Italy. There were increased incidences of gliomas and cardiac schwannomas. The translational relevance of these rare rat tumors for human disease is poorly understood. We examined the genetic alterations in RFR-derived rat tumors through molecular characterization of important cancer genes relevant for human gliomagenesis. A targeted next-generation sequencing (NGS) panel was designed for rats based on the top 23 orthologous human glioma-related genes. Single
Synergistic effect of PAK and Hippo pathway inhibitor combination in NF2-deficient Schwannoma. Neurofibromatosis type 2 is a genetic disorder that results in the formation and progressive growth of schwannomas, ependymomas, and/or meningiomas. The NF2 gene encodes the Merlin protein, which links cell cortical elements to the actin cytoskeleton and regulates a number of key enzymes including Group I p21-activated kinases (PAKs), the Hippo-pathway kinase LATS, and mTORC. While PAK1 and PAK2 directly bind Merlin and transmit proliferation and survival signals when Merlin is mutated or absent, inhibition of Group 1 PAKs alone has not proven sufficient to completely stop the growth of NF2-deficient meningiomas or schwannomas in vivo, suggesting the need for a second pathway inhibitor
Fall-related injury among patients with vestibular schwannoma. Vestibular schwannoma can cause vestibular dysfunction; however, conflicting evidence exists regarding whether this affects the incidence of fall-related injuries in this patient population. This matched cross-sectional and cohort study assess the risk of fall-related injuries in patients with vestibular schwannoma. The study included patients with vestibular schwannoma treated at a tertiary referral hospital in Sweden between 1988 and 2014. Information on fall-related injuries was obtained from the National Patient Register, and matched population comparisons were randomly selected in a 1:25 ratio. Fall-related injuries occurring pre- (within 5 years before the diagnosis of vestibular schwannoma) and post-diagnostically (up to 3
Comparing the Accuracy and Reliability of ABC/2 and Planimetry for Vestibular Schwannoma Volume Assessment. Vestibular schwannoma (VS) is a common intracranial tumor that affects patients' quality of life. Reliable imaging techniques for tumor volume assessment are essential for guiding management decisions. The study aimed to compare the ABC/2 method to the gold standard planimetry method
Hearing Preservation Outcomes in 230 Consecutive Patients with Small Vestibular Schwannomas Treated with Microsurgery. To evaluate hearing preservation (HP) outcomes for patients with small sporadic vestibular schwannomas (VS) who elect to undergo microsurgical resection. Retrospective study. Tertiary single-academic institution. Individuals 18 years or older with small sporadic VS (≤15 mm) who
Cochlear Implantation With Sporadic Inner Ear Schwannomas: Outcomes in 106 Patients From an International Multi-Institutional Study. To evaluate cochlear implant speech perception among patients with sporadic inner ear schwannoma who underwent ipsilateral implantation. Retrospective multi-institutional cohort study. Eleven tertiary academic medical centers across Germany, Denmark, and the United States. One hundred six patients with sporadic inner ear schwannoma who received an ipsilateral cochlear implant from 2011 to 2022. Ipsilateral cochlear implantation with observation, stereotactic radiosurgery, or microsurgery for tumor management. Monosyllabic speech perception testing scores and rates of open-set speech perception. Among 106 patients studied, 101 (95%) achieved open-set speech
Analgesia After Vestibular Schwannoma Surgery in Europe-Potential for Reduction of Postoperative Opioid Usage. Excessively prescribed opioids promote chronic drug abuse and worsen a highly prevalent public health problem in the era of the opioid epidemic. This study aimed to (a) determine general analgesic prescription patterns after surgery for vestibular schwannoma (VS) with a focus on opioid
Intraoperative Electrical Stapedius Reflex Testing to Monitor Cochlear Nerve Integrity during Simultaneous Vestibular Schwannoma Resection and Cochlear Implantation. To compare the utility of intraoperative electrically evoked auditory brainstem response (eABR) and electrically evoked stapedial reflex testing (eSRT) for cochlear nerve integrity monitoring during simultaneous translabyrinthine resection of vestibular schwannoma (VS) and cochlear implantation. Historical cohort study. Tertiary academic referral center. Eleven patients (12 cases) who underwent translabyrinthine tumor resection with simultaneous placement of a standard, unmodified cochlear implant (CI). A CI placed at the beginning of the operation before tumor resection to facilitate intraoperative cochlear nerve monitoring
Brain with coexistent acoustic schwannoma and ependymoma. This particular case is a world-first with no previous literature reports on patients presenting with both benign acoustic schwannoma and malignant ependymoma. A 60-year-old woman with unexplained right-sided hearing loss that had worsened progressively over 4 years, along with intermittent dizziness that had begun 3 years prior. Our preliminary diagnosis included: (1) Right acoustic neuroma; (2) Ependymoma of the fourth ventricle; and (3) Hydrocephalus. We employed the right sigmoid sinus posterior approach combined with the posterior median approach, beginning with removal of the fourth ventricle tumor and then proceeding to acoustic schwannomas resection through rotating operation positions. The case presented significant challenges
Automatic Segmentation of Vestibular Schwannoma From MRI Using Two Cascaded Deep Learning Networks. Automatic segmentation and detection of vestibular schwannoma (VS) in MRI by deep learning is an upcoming topic. However, deep learning faces generalization challenges due to tumor variability even though measurements and segmentation of VS are essential for growth monitoring and treatment
Airway-centered invasive pulmonary aspergillosis featuring histopathologic fruiting bodies in an immunocompetent patient with a rare incidental finding of thyroid gland Schwannoma: a case report. Invasive pulmonary aspergillosis (IPA) is typically associated with immunocompromised patients, but rare occurrences have been documented in immunocompetent individuals. This presents diagnostic and therapeutic challenges due to atypical presentations and less apparent risk factors. A 67-year-old Cambodian American female with a history of stable pulmonary nodules and a left neck schwannoma presented with a two-week history of cough and hemoptysis. Imaging revealed a left lower lobe lung mass suspicious for malignancy. Biopsy and bronchoalveolar lavage confirmed the diagnosis of invasive pulmonary
Preoperative cVEMP Results Predict Developing Prolonged Dizziness After Vestibular Schwannoma Surgery. To assess pretreatment factors including preoperative vestibular function tests evaluated using cVEMP and caloric tests, which correlate with the development of prolonged dizziness after vestibular schwannoma resection. Retrospective cohort study. Academic tertiary referral centers. Patients with vestibular schwannoma who underwent surgery and completed preoperative vestibular function tests and questionnaires. Diagnostic. Participants were divided into prolonged dizziness and nonprolonged dizziness groups according to their postoperative DHI scores. The rates of abnormal results of preoperative vestibular function tests (caloric test, cVEMP), including other factors such as preoperative HADS
Effect of Simvastatin on Irradiated Primary Vestibular Schwannoma Cells. Simvastatin enhances radiation cytotoxicity of primary vestibular schwannoma (VS) and NF2-mutant human Schwann (HS01) cells. Approximately 10% of VS progress after radiotherapy. Simvastatin is a lipid-lowering medication that promotes apoptosis, inhibits cell proliferation, and enhances radiation response in various cancers
The Dural Deviation Ratio: A Novel Indicator for Preoperative Differentiation of Intradural Extension in Spinal Dumbbell Tumors Schwannomas Using Axial T2-weighted MRI. This study investigates the potential of using dural deviation in axial T2-weighted MRI to differentiate between Eden type-2 and type-3 spinal dumbbell schwannomas preoperatively. A retrospective analysis of 43 patients with spinal dumbbell Schwannomas was conducted. Tumors were classified into Eden type-2 or type-3 based on the need for dural incision during surgery. The dural deviation ratio (D-ratio) was measured using axial T2-weighted MRI. Statistical significance and diagnostic accuracy were assessed with Mann-Whitney U test and receiver operating characteristic (ROC) analysis. The authors declare no conflicts
Adaptation of dose-prescription for vestibular schwannoma radiosurgery taking body contouring method and heterogeneous material into account. Majority of vestibular schwannoma (VS) patients have undergone gamma-knife radiosurgery (GKRS) with favorable results. Clinical evidence is derived from doses calculated with a type-a algorithm, which in this case assumes all material to be water. A type-b
Angiotensin-Receptor Blockers Prevent Vestibular Schwannoma-Associated Hearing Loss. Vestibular schwannoma (VS) tumors typically present with sensorineural hearing loss (SNHL). Losartan has recently demonstrated prevention of tumor-associated SNHL in a mouse model of VS through suppression of inflammatory and pro-fibrotic factors, and the current study investigates this association in humans
Quality of Information Provided by Artificial Intelligence Chatbots Surrounding the Management of Vestibular Schwannomas: A Comparative Analysis Between ChatGPT-4 and Claude 2. To examine the quality of information provided by artificial intelligence platforms ChatGPT-4 and Claude 2 surrounding the management of vestibular schwannomas. Cross-sectional. Skull base surgeons were involved from different centers and countries. Thirty-six questions regarding vestibular schwannoma management were tested. Artificial intelligence responses were subsequently evaluated by 19 lateral skull base surgeons using the Quality Assessment of Medical Artificial Intelligence (QAMAI) questionnaire, assessing "Accuracy," "Clarity," "Relevance," "Completeness," "Sources," and "Usefulness." The scores