minutes.1 Other effects include increased energy and alertness, increased body temperature, increased heart rate and blood pressure,8,9 agitation, paranoia, suppressed appetite, muscle spasms, stroke, fainting and overdose. An overdose can involve chest pain, arrhythmia, confusion, convulsions, respiratory depression, coma or death.8 Long-Term Effects Longer-term effects of cocaine use are sleep disturbance, weight loss, tolerance to the drug, depression, cardiovascular problems,9, 10 nasal damage (through snorting), kidney failure,9 throat and bronchial damage (through crack smoking),11 headaches, hallucinations, seizure, and attention and memory disruptions. Maternal use of cocaine during pregnancy can result in low birth weight (and related long-term health complications) in newborns.12,13