Stimulant laxatives (bisacodyl, senna and sennosides, sodiumpicosulfate) available over-the-counter: new measures to support safe use Stimulant laxatives (bisacodyl, senna and sennosides, sodiumpicosulfate) available over-the-counter: new measures to support safe use - GOV.UK Skip to main content Cookies on GOV.UKWe use some essential cookies to make this website work.We’d like to set on GOV.UK * Moving to the UK from Ukraine * Coronavirus (COVID-19) * Find a job * Check benefits and financial support you can get * Universal Credit account: sign in 1. Home 2. Drug Safety Update Stimulant laxatives (bisacodyl, senna and sennosides, sodiumpicosulfate) available over-the-counter: new measures to support safe use We have introduced pack size restrictions, revised recommended
Comparing the bowel cleansing efficacy between sodiumpicosulfate vs. 2L polyethylene glycol electrolyte lavage solution for colonoscopy: a prospective observational study. This study aimed to compare the bowel cleansing efficacy, adverse reactions, and patient compliance of two low-volume bowel preparation regimens, sodiumpicosulfate (PICO) and 2 L polyethylene glycol electrolyte lavage
Comparison of the efficacy and tolerability of elobixibat plus sodiumpicosulfate with magnesium citrate and split-dose 2-L polyethylene glycol with ascorbic acid for bowel preparation before outpatient colonoscopy: a study protocol for the multicentre, Sodiumpicosulfate (SP)/magnesium citrate (MC) and polyethylene glycol (PEG) plus ascorbic acid are recommended by Western guidelines
Comparison of optimal bowel cleansing effects of 1L polyethylene glycol with ascorbic acid versus sodiumpicosulfate with magnesium citrate: A randomized controlled study. Various low-volume bowel cleansing formulations that improve compliance have been approved and are being used in clinical practice. This study aimed to compare the effectiveness of 1 L polyethylene glycol (PEG) with ascorbic acid with that of sodiumpicosulfate (PICO) with magnesium citrate. This was a multicenter, randomized controlled, non-inferiority study. Patients were randomized into a 1 L PEG with ascorbic acid group and a PICO with magnesium citrate group according to the bowel cleansing agent used. Colonoscopy was performed as a single-blind study wherein the endoscopist had no information about any bowel
Comparative study between manitol and sodiumpicosulfate with magnesium oxide solutions in the preparation for colonoscopy. This prospective, randomized and double-blind study aims to compare two different protocols used for bowel preparation in patients scheduled for colonoscopy. The protocols were composed by solutions of Mannitol or sodiumpicosulfate combined with magnesium oxide. Patients , although the review of literature shows a difference in favor of preparation made with Mannitol solution regarding the colon neatness during the exam. In line with the literature, patients who used Mannitol solution had more side effects, highlighting the significant difference found for vomiting and sleep impairment. The preparation with SodiumPicosulfate with Magnesium Oxide was significantly superior
The risk of surgical site infection of oral sulfate tablet versus sodiumpicosulfate for bowel preparation in colorectal cancer surgery: a randomized clinical trial. Oral sulfate tablets are abundantly used for bowel preparation before colonoscopy. However, their efficiency and safety for bowel preparation before colorectal surgery remain ill-defined. Herein, we aimed to compare the surgical site infection rates and efficiency between oral sulfate tablets and sodiumpicosulfate. We designed a prospective, randomized, phase 2 clinical trial. Patients with colorectal cancer aged 19-75 years who underwent elective bowel resection and anastomosis by minimally invasive surgery were administered oral sulfate tablets or sodiumpicosulfate. Eighty-three cases were analyzed from October 2020
Comparison Between Same-Day and Split-Dose Preparations with SodiumPicosulfate/Magnesium Citrate: A Randomized Noninferiority Study. Sodiumpicosulfate/magnesium citrate (SPMC) is a small-volume bowel cleansing agent with similar efficacy to and better tolerability than polyethylene glycol. However, we found no data on which SPMC preparation (same-day vs. split-dose) provides better bowel
Split-dose versus day-before regimen of sodiumpicosulfate plus magnesium citrate for bowel cleansing before colonoscopy in children: Randomized controlled trial. Polyethylene glycol (PEG) split-dose regimen is recommended as the option of choice for colon preparation before colonoscopy in children and adults. Sodiumpicosulfate plus magnesium citrate (SPMC) is equally effective but better
Safety and efficacy of sodiumpicosulfate, magnesium oxide, and citric acid bowel preparation in patients with baseline renal impairment or diabetes: subanalysis of a randomized, controlled trial. Selecting a bowel preparation for patients with renal impairment or diabetes requires special consideration. We aimed to describe the effect of baseline renal impairment or diabetes on the safety , efficacy, and tolerability of low-volume sodiumpicosulfate, magnesium oxide, and citric acid (SPMC) ready-to-drink oral solution bowel preparation. A secondary analysis was performed from a randomized, assessor-blinded study of SPMC oral solution bowel preparation in participants with mild or moderate baseline renal impairment or diabetes. Primary efficacy endpoint ('responders') was the proportion
Split-dose 1 L polyethylene glycol (PEG) with ascorbate is non-inferior to split-dose PEG with sodiumpicosulfate and magnesium citrate with similar tolerability: a randomized study. Post-marketing studies comparing low-volume polyethylene glycol (PEG)-based regimens are limited. This randomized study aimed to compare the efficacy and tolerability of a novel 1-L low-volume PEG-based preparation : 1 L PEG+Asc (PEG3350, sodium ascorbate, sodium sulfate, ascorbic acid, sodium chloride, and potassium chloride) with PEG+SPMC (PEG3350, sodium chloride, potassium chloride and sodium sulfate, sodiumpicosulfate, magnesium oxide, citric acid, and aspartame), prior to routine colonoscopy at an Australian tertiary referral center. Outpatients undergoing colonoscopy were randomized to receive either
SodiumPicosulfate An official website of the United States government Here's how you know Log inAccess keysNCBI HomepageMyNCBI HomepageMain ContentMain NavigationBookshelfSearch databaseBooksAll DatabasesAssemblyBiocollectionsBioProjectBioSampleBooksClinVarConserved DomainsdbGaPdbVarGeneGenomeGEO DataSetsGEO ProfilesGTRHomoloGeneIdentical Protein GroupsMedGenMeSHNLM Levels and EffectsSummary of Use during LactationSodium picosulfate is not absorbed from the gastrointestinal tract, and its active metabolite, which is absorbed, is not detectable in breastmilk. Sodiumpicosulfate can be taken during breastfeeding and no special precautions are required.Drug LevelsMaternal Levels. Sixteen postpartum women who were not breastfeeding, but were producing at least 200 mL
A Randomized Trial Comparing the Bowel Cleansing Efficacy of SodiumPicosulfate/Magnesium Citrate and Polyethylene Glycol/Bisacodyl (The Bowklean Study). Bowel cleansing is essential for a successful colonoscopy, but the ideal clearing agent and the volume have yet to be determined. A small-volume cleanser is important for patient compliance. This study aimed to compare the bowel cleansing efficacy, safety, tolerability, and acceptability of a 300-mL small-volume sodiumpicosulfate/magnesium citrate (PSMC) preparation-Bowklean with one 2-L polyethylene glycol (PEG)/bisacodyl-Klean-Prep/Dulcolax preparation under identical dietary recommendations. This multicenter, randomized, parallel-group, pre-specified noninferiority study enrolled 631 outpatients scheduled to undergo colonoscopy
A Randomized, Endoscopist-Blinded, Prospective Trial to Compare the Efficacy and Patient Tolerability between Bowel Preparation Protocols Using SodiumPicosulfate Magnesium Citrate and Polyethylene-Glycol (1 L and 2 L) for Colonoscopy. Patient compliance during bowel preparation is important for successful colonoscopy. Bowel preparation with polyethylene glycol (PEG), the most commonly used solution for cleansing, involves the unpleasant ingestion of a large amount of liquid. Sodiumpicosulfate magnesium citrate (SP-MC) solution is an alternative option with better palatability than PEG. Therefore, in this study, we compared the efficacy and patient tolerability among the following three bowel preparation protocols: 2 L PEG-ascorbic acid (ASc), 1 L PEG-ASc plus bisacodyl, and SP-MC 340 mL
Pediatric bowel preparation: Sodiumpicosulfate, magnesium oxide, citric acid vs polyethylene glycol, a randomized trial. Bowel preparation in children can be challenging. To describe the efficacy, safety, and tolerability of sodiumpicosulfate, magnesium oxide, and citric acid (SPMC) bowel preparation in children. Phase 3, randomized, assessor-blinded, multicenter study of low-volume, divided
Clinical comparison of low-volume agents (oral sulfate solution and sodiumpicosulfate with magnesium citrate) for bowel preparation: the EASE study. This study compared the efficacy, compliance, and safety of bowel preparation between sodiumpicosulfate with magnesium citrate (SPMC) and oral sulfate solution (OSS). A prospective randomized multicenter study was performed. Split preparation
Colon cleansing efficacy and safety with 1 L NER1006 versus sodiumpicosulfate with magnesium citrate: a randomized phase 3 trial. Polyethylene glycol (PEG) bowel preparations are widely used for precolonoscopy bowel cleansing. This phase 3 trial assessed the efficacy, safety, and tolerability of the novel 1 L PEG-based NER1006 vs. sodiumpicosulfate plus magnesium citrate (SP + MC) in day
Efficacy and Safety of SodiumPicosulfate/Magnesium Citrate for Bowel Preparation in a Physically Disabled Outpatient Population: A Randomized, Endoscopist-Blinded Comparison With Ascorbic Acid-Enriched Polyethylene Glycol Solution Plus Bisacodyl (The PIC Because of its volume, adequate bowel preparation remains problematic in physically unfit patients. This study aimed to compare a small-volume sodiumpicosulfate/magnesium citrate preparation with a 2-L ascorbic acid-enriched polyethylene glycol solution plus bisacodyl. This study has a noninferiority design, assuming that ascorbic acid-enriched polyethylene glycol solution plus bisacodyl is 70% efficacious in achieving an Ottawa score ≤7 and accepting a difference in success rate of <15% with a target enrollment of 146 patients per group
Aquanet Bowel Cleansing Device Versus Oral SodiumPicosulfate for Pre-Endoscopy Bowel Preparation: Propensity Score Analysis for Interventional Effectiveness Evaluation Colonoscopy procedures are commonly performed and have high success rates. However, poor or inadequate bowel preparation is one of the most common reasons for a repeated or failed colonoscopy. We therefore performed an observational study followed by propensity score modeling to evaluate and compare the quality of bowel preparation with the use of Aquanet bowel cleansing devices (BCDs) versus the use of oral sodiumpicosulfate solution. We performed a prospective cross-sectional study to compare the quality of pre-endoscopic bowel preparation using a BCD with oral solution. Our major outcome of interest was the quality
Efficacy and tolerability of 2-L polyethylene glycol with ascorbic acid versus sodiumpicosulfate with magnesium citrate: a randomized controlled trial. Previous studies comparing 2-L polyethylene glycol (PEG)-based solution with ascorbic acid (PEG/Asc) with sodiumpicosulfate/magnesium citrate (SP/MC) drew inconclusive results. This study aimed to compare a 2-L-PEG/Asc with SP/MC by split
[Comparison of colon-cleansing methods in preparation for colonoscopy-comparative of solutions of mannitol and sodiumpicosulfate]. The purpose of the present study is to compare intestinal preparation with mannitol and sodium picosulphate, assessing patient's acceptance, side effects and cleaning capacity. This is a prospective, nom randomized, blind study, in which the evaluator had no information about the preparation applied. The sample obtained was divided into two groups according to the bowel preparation applied, with 153 patients prepared with 10% mannitol and 84 patients with sodiumpicosulfate. The evaluation of colon preparation was done using the Boston Scale (Boston Bowel Preparation Scale - BBP) through a three-point scoring system for each of the three regions of the colon