"Spleen transplantation"

sensitized kidney and kidney-pancreas recipients in active waiting-list.Intervention(s), exposure(s)The study aims to summarize the state of art of splenic transplantation.We want to enlighten the role of splenic transplantation over the last decades specifically focusing on the effect of spleen transplantation over the immunity response and the viability of temporary spleen transplantation.Literature conducted on human patient undergoing spleen transplantation and studies reporting association between splenic transplantation and immunity response; we accepted both transient and definitive transplantation.ContextThe study aims to summarize the state of art of splenic transplantation.We want to enlighten the role of splenic transplantation over the last decades specifically focusing on the effect

Spleen Transplant in Solid Organ Transplantation Although the notions that kidney transplantation is the treatment of choice for patients with end-stage renal disease and that simultaneous kidney and pancreas transplant is the only treatment able to restore euglycemia in patients with type 1 diabetes and selected patients with type 2 diabetes, are now consolidated, rates of transplantation remain allograft failure is common.This protocol has been designed to demonstrate the feasibility and efficacy of spleen transplant as a desensitization strategy for highly sensitized patients, potential candidates of kidney or simultaneous kidney pancreas transplant with (positive cross-match by flow cytometry (T or B) or B positive standard cross-match). After obtaining surgical and research consent at a pre

of PDAC with a mesenchymal phenotype, which was accompanied by increased liver metastases and decreased survival. Lineage tracing revealed that pancreatic Reck deletion induced epithelial-mesenchymal transition (EMT) in PDAC cells, giving rise to inflammatory cancer-associated fibroblast-like cells in mice. Splenic transplantation of Reck-null PDAC cells resulted in numerous liver metastases

spleen transplantation. Spleen-derived CD11b cells purified from fibrotic livers were then annotated by scRNA-seq and a subtype of CD11b CD43 Ly6C splenic monocytes (sM-1s) was identified, which was markedly expanded in both spleens and livers of mice with liver fibrosis. sM-1s exhibited mature feature with high expressions of F4/80, produced much ROS, and manifested preferential migration into livers

-specific Calr-deficient mice. CALR deficiency had little effect on the leukocyte count, hemoglobin levels, or platelet count in peripheral blood. However, Calr-deficient mice showed some hematopoietic properties of MPN, including decreased erythropoiesis and increased myeloid progenitor cells in the bone marrow and extramedullary hematopoiesis in the spleen. Transplantation experiments revealed that Calr

organs and varices in the upper abdomen. Esophagogastroduodenoscopy revealed portal hypertensive gastropathy. Conventional total splenectomy was performed in this patient because of an enlarged spleen and unknown etiology, preoperatively. Upon surgery, splenomegaly with polycystic content and varicose vessels over the omentum were noted. Autologous spleen transplantation was not performed because

transplanted. To observe the effect of ART1 on tumor growth or liver metastasis in vivo, a spleen transplant tumor model of CT26 cells in BALB/c mice was successfully constructed. Expression levels of focal adhesion kinase (FAK), Ras homolog gene family member A (RhoA) and the downstream factors, c‑myc, c‑fos and cyclooxygenase‑2 (COX‑2) proteins, were measured in vivo. The results demonstrated that ART1 gene silencing inhibited the growth of the spleen transplanted tumor and its ability to spread to the liver via metastasis. There was also an accompanying increase in expression of FAK, RhoA, c‑myc, c‑fos and COX‑2, whereas CT26 cells with ART1 overexpression demonstrated the opposite effect. These results suggest a potential role for ART1 in the proliferation and invasion of CT26 cells

transplant inhibited Th17 cell differentiation, alloreactive T cell responses, and STAT3 expression in mice with GVHD. On the other hand, the differentiation of Tregs and STAT5 production were enhanced by GRIM19. Overall, the severity of GVHD was decreased in mice that had received GRIM19 transgenic bone marrow and spleen transplants. Transplantation from GRIM19-overexpressing cells downregulated

autotransplantation may improve the outcomes of such patients. Omental splenic transplantation is the standard procedure but may be difficult when performing laparoscopic colorectal surgery or when total or subtotal omentectomy is required. This animal model study was performed to evaluate the impact of splenic autotransplantation to the groin area on colonic wound healing. Thirty rats were divided into three

-term investigation of combined G-CSF and BM MNC treatment at 48 hours indicated splenic accumulation of granulocytes and transplanted cells, accompanied by a significant rise of granulocytes in the circulation and the ischemic brain. G-CSF improved functional recovery in spontaneously hypertensive rats, but this effect was abolished by cotransplantation of BM MNC after 48 hours. In the spleen , transplanted cells may hinder the clearance of granulocytes that were massively increased by G-CSF. Increased circulation and infiltration of granulocytes into the ischemic brain may be detrimental for stroke outcome.

717-9. [QxMD MEDLINE Link]. 57. Peitzman AB, Heil B, Rivera L. Blunt splenic injury in adults: Multi-institutional Study of the Eastern Association for the Surgery of Trauma. J Trauma. 2000 Aug. 49(2):177-87; discussion 187-9. [QxMD MEDLINE Link]. 58. Pisters PW, Pachter HL. Autologous splenic transplantation for splenic trauma. Ann Surg. 1994 Mar. 219(3):225-35. [QxMD MEDLINE

717-9. [QxMD MEDLINE Link]. 57. Peitzman AB, Heil B, Rivera L. Blunt splenic injury in adults: Multi-institutional Study of the Eastern Association for the Surgery of Trauma. J Trauma. 2000 Aug. 49(2):177-87; discussion 187-9. [QxMD MEDLINE Link]. 58. Pisters PW, Pachter HL. Autologous splenic transplantation for splenic trauma. Ann Surg. 1994 Mar. 219(3):225-35. [QxMD MEDLINE

]. 57. Peitzman AB, Heil B, Rivera L. Blunt splenic injury in adults: Multi-institutional Study of the Eastern Association for the Surgery of Trauma. J Trauma. 2000 Aug. 49(2):177-87; discussion 187-9. [QxMD MEDLINE Link]. 58. Pisters PW, Pachter HL. Autologous splenic transplantation for splenic trauma. Ann Surg. 1994 Mar. 219(3):225-35. [QxMD MEDLINE Link]. 59. Poulin EC

]. 57. Peitzman AB, Heil B, Rivera L. Blunt splenic injury in adults: Multi-institutional Study of the Eastern Association for the Surgery of Trauma. J Trauma. 2000 Aug. 49(2):177-87; discussion 187-9. [QxMD MEDLINE Link]. 58. Pisters PW, Pachter HL. Autologous splenic transplantation for splenic trauma. Ann Surg. 1994 Mar. 219(3):225-35. [QxMD MEDLINE Link]. 59. Poulin EC

. To our knowledge, this is the first report of human splenic transplantation in a large series. All primary multivisceral recipients who received a donor spleen (N = 60) were compared with those who did not receive a spleen (N = 81). Thirty-five of 60 (58%) are alive in the spleen group, and 39 of 81 (48%) are alive in control group (P = 0.98). In univariate analysis, splenic recipients showed

The Regeneration of Autoplastic Splenic Transplants

ATTEMPTED SPLEEN TRANSPLANT IN CLASSICAL HEMOPHILIA

Autologous splenic transplantation.

Anti-A Production by a Group 0 Spleen Transplanted to a Group A Recipient A group A1 diabetic received a pancreas-spleen transplant from a group 0 donor. Severe immune hemolysis due to anti-A ensued, requiring graft splenectomy. The transplanted spleen can be a potent source of blood group antibody.