"Status epilepticus"

Status epilepticus Skip to main contentSkip to searchAbout usHelpSubscribeAccess through your institutionLog inBMJ Best PracticeSearchSearchSelect languageStatus epilepticus MENULog in or subscribe to access all of BMJ Best PracticeLast reviewed:11 May 2023Last updated:07 Jun 2023SummaryStatus epilepticus is a life-threatening neurological condition and carries a high mortality and morbidity . The most common acute causes of status epilepticus are hypoxia, stroke, metabolic abnormalities, alcohol intoxication/withdrawal, and poor anticonvulsant therapy adherence (in people with known epilepsy).If the patient with convulsive status epilepticus has an individualised emergency management plan that is immediately available, administer medication as detailed in the plan. If no emergency management

Pre-hospital and emergency department treatment of convulsive status epilepticus in adults: an evidence synthesis Pre-hospital and emergency department treatment of convulsive status epilepticus in adults: an evidence synthesis * Text only * * Home * Journals * * Other NIHR research * * For authors * For reviewers * About * * Accessibility * Journals LibraryNHS NIHR - National Institute

Japanese guidelines for treatment of pediatric status epilepticus

Management of Refractory Status Epilepticus Management of Refractory Status Epilepticus - Emergency MedicineSkip to contentSkip to searchSkip to footerWashington University School of Medicine in St. LouisEmergency MedicineOpen MenuBackCloseMenuSearch for:SearchClose Search * WelcomeWelcome * Mission * Videos * Clinical Sites * Explore St. Louis * Our TeamOur Team * Faculty * APP * News * EventsEvents * BJH & WU EMS Critical Care Symposium * Lewis Health Policy Symposia * Jermyn LecturesJermyn Lectures * 2019 * Women in Medicine Symposium * Code 3 Conference * Project PREPARE * Guidelines for Patient Data Request Management * EM Accounting ServicesOpen Search Management of Refractory Status Epilepticus Washington University Emergency Medicine

Status epilepticus ' Emergency management in children Status epilepticus – Emergency management in children | Children's Health Queensland Skip to main content Skip to main navigation health.qld.gov.au Contact Us Search Menu Queensland Government Children's Health Queensland Search this website Search MenuClose * Home * Going to hospital Going to hospital Going to hospital * How in childrenOn this page View resources * Emergency management flowchart [PDF 1445.82 KB] - 2 pages * Seizure chart (QH only) - 1 pageKey points * Status epilepticus (defined as seizure lasting greater than five minutes or repeated seizures without full recovery to normal conscious level between episodes) is a neurological emergency. * Refractory status epilepticus is associated with significant mortality

Levetiracetam as an alternative to phenytoin for second-line emergency treatment of children with convulsive status epilepticus: the EcLiPSE RCT Levetiracetam as an alternative to phenytoin for second-line emergency treatment of children with convulsive status epilepticus: the EcLiPSE RCT * Text only * * Home * Journals * * Other NIHR research * * For authors * For reviewers * About * * Download report PDF * Download report documents * Download report documents * * Disclosure of interest * * * Download report XML * * Citation Tools * Print * * * * Responses to this report (0) * Permissions information View ProjectThis trial found that levetiracetam was not superior to phenytoin in the time taken to terminate convulsive status

Status Epilepticus Printed copies of this document may not be up to date, obtain the most recent version from www.cats.nhs.uk Children’s Acute Transport Service provides paediatric intensive care retrieval for Great Ormond Street, The Royal Brompton and St Mary’s NHS Trusts. Funded and accountable to the North Thames Paediatric Intensive Care Commissioning Group through Great Ormond Street NHS Trust. Page 1 of 5 Children’s Acute Transport Service Clinical Guidelines Status Epilepticus Document Control Information Author E Sturgess E Randle Author Position CATS ANP CATS Consultant Document Owner M Clement Document Owner Position CATS Nursing and Operational Lead Document Version Version 6 Replaces Version Version 5 - January 2020 First Introduced

Levetiracetam Compared With Phenytoin Or Fosphenytoin In Benzodiazepine-Refractory Pediatric Status Epilepticus HomeReviewsTherapy (NNT) ReviewsDiagnosis (LR) ReviewsAboutThe NNT, ExplainedThe NNT Rating SystemtheNNT Editorial ProcessThe NNT Intervention QuizAbout theNNT TeamSubmit an articleAccountLoginSign upContactDONATELevetiracetam Compared With Phenytoin Or Fosphenytoin In Benzodiazepine -Refractory Pediatric Status EpilepticusAssociated with similar time to seizure cessation and safety outcomesBenefits in NNTNot applicable (similar efficacy and safety)Harms in NNTNot applicable (similar efficacy and safety)View As: NNT %SourceKlowak JA, Hewitt M, Catenacci V, et al. Levetiracetam versus phenytoin or fosphenytoin for second-line treatment of pediatric status epilepticus: a meta-analysis

Sustained effort network for treatment of status epilepticus/European academy of neurology registry on adult refractory status epilepticus (SENSE-II/AROUSE). Status Epilepticus (SE) is a common neurological emergency associated with a high rate of functional decline and mortality. Large randomized trials have addressed the early phases of treatment for convulsive SE. However, evidence regarding third-line anesthetic treatment and the treatment of nonconvulsive status epilepticus (NCSE) is scarce. One trial addressing management of refractory SE with deep general anesthesia was terminated early due to insufficient recruitment. Multicenter prospective registries, including the Sustained Effort Network for treatment of Status Epilepticus (SENSE), have shed some light on these questions

Seizure control via pH manipulation: a phase II double-blind randomised controlled trial of inhaled carbogen as adjunctive treatment of paediatric convulsive status epilepticus (Carbogen for Status Epilepticus in Children Trial (CRESCENT)). Paediatric convulsive status epilepticus is the most common neurological emergency presenting to emergency departments. Risks of resultant neurological . There is strong pre-clinical evidence that pH (acid-base balance) is an important determinant of seizure commencement and cessation, with seizures tending to start under alkaline conditions and terminate under acidic conditions. These mechanisms may be particularly important in febrile status epilepticus: prolonged fever-related seizures which predominantly affect very young children. This trial will assess

When patients with Creutzfeldt-Jakob disease are misdiagnosed as having nonconvulsive status epilepticus. Contemporary studies report nonconvulsive status epilepticus (NCSE) in Creutzfeldt-Jakob disease (CJD), based on benzodiazepine (BZP)-responsive epileptiform discharges on the electroencephalogram (EEG), with the following false syllogism: (1) intravenous (IV) administration of BZPs usually

Autism, Electrical Status Epilepticus in Sleep, and a Likely Pathogenic SEMA6B Variant. This case report describes a boy aged 8 years with autism spectrum disorder who was diagnosed with electrical status epilepticus in sleep (ESES) and found to have a likely pathogenic variant in the SEMA6B gene. The patient presented with developmental regression and cognitive decline. An electroencephalogram

New onset refractory status epilepticus: Long-term outcomes beyond seizures. We propose and prioritize important outcome domains that should be considered for future research investigating long-term outcomes (LTO) after new onset refractory status epilepticus (NORSE). The study was led by the international NORSE Institute LTO Working Group. First, literature describing the LTO of NORSE survivors

Nonconvulsive status epilepticus in patients under intensive care: Should we view epilepsy as a sleep disorder? Nonconvulsive status epilepticus (NCSE) was initially described in patients with typical and atypical absence status epilepticus (ASE) characterized by states of confusion varying in severity and in focal epilepsies with or without alteration of consciousness. Continuous EEG monitoring ), there is no vigilance impairment. This contrasts with metabolic/toxic encephalopathies, which exhibit monomorphic generalized periodic discharges in which patients may become comatose and die. The extended concept of NCSE in comatose patients may lead to an inflated assessment of NCSE, implying a potentially worse prognosis compared to convulsive status epilepticus.

Tenets of timing: An evidence based comprehensive review on time-lag in the management of pediatric status epilepticus and its effect on clinical outcomes. Pediatric status epilepticus (SE) is a life-threatening, time-sensitive neurological emergency. The adequate treatment of pediatric patients with SE is challenging, especially when the principles of time are considered. Various clinical trials and studies [especially one of the most important randomized controlled trials of the present time, 'ESETT (Established Status Epilepticus Treatment Trial)'] compared the effectiveness of 3 antiseizure medications (ASMs) in patients with SE, providing robust evidence for clinical practice. Meticulous analysis of care delivery is an essential component as far as optimal management of pediatric SE

Electrographic and Clinical Determinants of Good Outcome After Postanoxic Status Epilepticus. Postanoxic electrographic status epilepticus (PSE) affects up to a third of all comatose patients after cardiac arrest (CA) and is associated with high mortality. Late PSE onset (>24 hours), from a restored continuous background pattern, and absence of established indicators of poor outcome

Neuro-Behcet's Masquerading as Status Epilepticus and Meningoencephalitis in the Emergency Department. Behcet disease (BD) is a rare small vessel vasculitis that commonly manifests as recurrent painful oral or genital ulcerations, uveitis, and skin lesions. Some patients with BD develop neurological symptoms termed neuro-Behcet's disease. In the emergency department setting, these symptoms can be mistaken for other common acute issues including stroke, infection, epilepsy, multiple sclerosis, toxin ingestion, or psychiatric conditions. We present a case of a 28-year-old male with neuro-BD mimicking status epilepticus and meningoencephalitis. He was actively seizing on arrival and febrile at 103.8 F. The patient also had a history of vasculitis, uveitis, and genital lesions which raised suspicion

A Unique Case of MBD5 and CCM2 Deletions Leading to a Severe Neurological Phenotype With Prolonged Status Epilepticus. Heterozygous pathogenic variants in MBD5 (MIM*611472) and CCM2 (MIM*607929) cause autosomal dominant intellectual developmental disorder 1 (MIM#156200) and cerebral cavernous malformations-2 (MIM#603284), respectively. Both conditions may present with seizures, epilepsy , and status epilepticus. However, super-refractory status epilepticus, defined as seizures lasting more than 24 h, has not been described in either condition. Herein, we describe the case of a 14-year-old boy with a neurodevelopmental disorder caused by a heterozygous MBD5 deletion as well as multiple cerebral cavernous malformations caused by a CCM2 deletion, who presented with prolonged super-refractory

Emergency department and inpatient interhospital transfers for patients with status epilepticus. Interhospital transfers for status epilepticus (SE) are common, and some are avoidable and likely lower yield. The use of interhospital transfer may differ in emergency department (ED) and inpatient settings, which contend with differing clinical resources and financial incentives. However, transfer

A peptide-neurotensin conjugate that crosses the blood-brain barrier induces pharmacological hypothermia associated with anticonvulsant, neuroprotective, and anti-inflammatory properties following status epilepticus in mice. Preclinical and clinical studies show that mild to moderate hypothermia is neuroprotective in sudden cardiac arrest, ischemic stroke, perinatal hypoxia/ischemia, traumatic following peripheral administration. One of these conjugates, VH-N412, displayed improved stability, binding potential to both the LDLR and NTSR-1, rodent/human cross-reactivity and improved brain distribution. In a mouse model of kainate (KA)-induced status epilepticus (SE), VH-N412 elicited rapid hypothermia associated with anticonvulsant effects, potent neuroprotection, and reduced hippocampal