"Suloctidil"

In vitro and in vivo effects of suloctidil on growth and biofilm formation of the opportunistic fungus Candida albicans As the most frequent fungal pathogen in humans, can develop serious drug resistance because its biofilms are resistant to most antifungal agents; this leads to an urgent need to develop novel antifungals. Here, we evaluated the efficacy of an antithrombotic drug, suloctidil , against biofilms and . We found that suloctidil is effective to inhibit biofilm, with a minimum inhibitory concentration (MIC) of 4 μg/mL, a biofilm inhibiting concentration (BIC) of 16 μg/mL and a biofilm eradicating concentration (BEC) of 64 μg/mL. Furthermore, the concentration-dependent characteristics of suloctidil were shown by its time-kill curves. Scanning electron microscopy images clearly

; “amlodipine”, “bepridil”, “fendiline”, “mibefradil”, “perhexiline”, medications for functional gastrointestinal disorders; “alverine”, “camylofin”, “dicycloverine”, “mebeverine”, natural products ; “conessine”, “solasodine”, “tomatidine”, vasodilators ;” dilazep”, “suloctidil”, muscle relaxant; “cyclobenzaprine”, mucolytic ; “ambroxol”, medications of the nervous system; “cinnarizine”, “flunarizine

An evaluation of suloctidil in the prevention of deep vein thrombosis in neurosurgical patients. Suloctidil (200 mg t.i.d.) was compared with placebo in a randomized, double-blind trial to assess its value in preventing deep venous thrombosis (DVT) in high-risk neurosurgical patients, comprising 136 patients with brain or spinal tumour, head or spinal injury, or subarachnoid or intracranial hemorrhage. 125I fibrinogen leg scanning and impedance plethysmography were performed for up to 14 days to detect DVT. The two groups were also evenly balanced for DVT risk factors. Seventeen of 68 patients (25%) (95% confidence interval, 15-35%) treated with suloctidil and 12 of 68 patients (21%) (95% confidence interval, 11-32%) treated with placebo developed deep venous thrombosis. This observed

An experimental evaluation of the efficacy of suloctidil in the treatment of primary degenerative dementia. A double-blind, placebo-controlled randomized design was employed to test the efficacy and optimal dosage of Suloctidil in the treatment of primary degenerative dementia (PDD i.e., Alzheimer's disease). Initially, 30 geriatric patients with a diagnosis of PDD were matched for age, education , and handedness, and randomly assigned to one of three groups: (a) 600 mg. Suloctidil daily; (b) 450 mg. Suloctidil daily; (c) or placebo, for 12 weeks. All patients were administered individually a brief neuropsychological battery at pretreatment and at 12-week posttreatment. The tests were the Boston Naming Test, the Thurstone Word Fluency Test, the Trail Making Test, and the Grooved Pegboard. While

Effect of suloctidil on tomographically quantitated platelet accumulation in Dacron aortic grafts. Platelet deposition contributes to the thrombotic and embolic complications of prosthetic materials in man. To determine if the investigational platelet inhibitory drug suloctidil (200 mg 3 times daily) reduces platelet deposition on Dacron aortic grafts, a randomized, double-blind, crossover trial after platelet injection and was quantitated by a graft/blood ratio that compared indium-111 platelet activity in summed 1.8-cm-thick transaxial tomographic slices of the aortic graft to indium-111 platelet activity in well-counted whole blood. Compared with placebo, suloctidil failed to decrease the tomographic graft/blood ratio at 24 hours (6.2 +/- 1.3 vs 5.7 +/- 0.8) and 72 hours (11.4 +/- 2.9 vs

A secondary prevention, randomized trial of suloctidil in patients with a recent history of thromboembolic stroke. Four hundred and thirty-eight patients who had suffered a thromboembolic stroke not less than two weeks or more than four months previously, were entered into a placebo-controlled randomized clinical trial to determine whether suloctidil (200 mg t.i.d.) would influence the subsequent recurrence of stroke, the occurrence of myocardial infarction, or cardiovascular death. The two treatment groups were comparable at baseline with respect to important prognostic variables and there was good adherence to the study protocol during an average follow-up of 20 months. Significantly more patients complained of side-effects in the suloctidil group and more hepatotoxicity was also reported

[Evaluation of therapeutic effect of suloctidil in aged patients with cerebrovascular insufficiency. Double-blind study in comparison with placebo].

Double blind trial with suloctidil, a new vasoactive agent, in elderly patients with psycho-organic brain syndrome.

A double-blind study comparing suloctidil and placebo in chronic peripheral arteriopathy.

Medical treatment of intermittent claudication: a comparative double-blind study of suloctidil, dihydroergotoxine and placebo. Forty-five patients suffering from intermittent claudication were admitted to a double-blind non-crossover study. Three groups were constituted at random and treated for 2 months with either 100 mg suloctidil t.i.d. or 1.5 mg dihydroergotoxine methylate t.i.d. or placebo . From the results of measurements of pain-free walking distance and venous occlusion plethysmography recordings, suloctidil was shown to be active and significantly superior to dehydroergotoxine and placebo: in the two latter groups a decrease in calf blood perfusion after 2 months was also noted. The physician's overall assessment of response to treatment showed that suloctidil and dihydroergotoxine

Suloctidil: long-term trial in the aged. Study of microcirculation, viscosity, red cell deformability, fibrinolysis and lipid fractions. 15 aged patients with clinical and laboratory evidence of cerebrovascular insufficiency and/or myocardial sclerosis were given suloctidil (Locton) at the daily dose of 200 mg X 3, for 180 days, under the conditions of an open trial. Blood and plasma viscosity

Effects of long-term treatment with suloctidil on blood viscosity, erythrocyte deformability and total fibrinogen plasma levels in diabetic patients. 1-(4-Isopropylthiophenyl)-2-n-octylaminopropanol (suloctidil, Sulocton), a drug introduced into clinical practice for the treatment of cerebral and peripheral vascular insufficiency and its complications, has been shown to decrease blood hyperviscosity after long-term treatment in diabetic patients. Suloctidil was particularly effective in lowering measured blood viscosity at high shear rate (230 s-1). At low shear rate (0.77 s-1) a decreasing effect was also observed but reached a statistically significant level only after one month. Since neither total plasma fibrinogen levels nor red blood cell deformability were modified by suloctidil

Controlled trial of suloctidil in intermittent claudication. Forty-five patients with intermittent claudication were first treated with placebo tablets for 3 months and then randomly allocated to double-blind therapy with either suloctidil or placebo for 6 months. Walking distance improved significantly in both groups during the 3 months of placebo treatment. During the 6 months of double-blind treatment with a further significant improvement occurred only in the placebo group when all patients were analyzed. However, when patients who stopped for reasons unrelated to claudication such as angina and exhaustion during repeated walking tests were eliminated, only suloctidil-treated patients improved significantly. The evolution of leg flow and distal pressure was similar in the two treatment

Double-blind trial of suloctidil versus placebo in moderate to severe mental deterioration. A double-blind, parallel group, placebo-controlled study was carried out in 30 elderly patients with moderate to severe mental deterioration to assess the effect of suloctidil on their mental condition. A battery of clinical and psychometric evaluations failed to demonstrate any significant differences between the two groups at the end of a 6-month treatment period during which patients received either 200 mg suloctidil or placebo 3-times daily. However, further analysis of the results showed that in the sub-group of patients with moderate mental deterioration on entry, suloctidil treatment produced significant improvement from baseline in the Rey 15 words test and the results were significantly

Hypocholesterolaemic activity of suloctidil: double-blind, crossover short-term and long-term treatment trial. Two studies were carried out in patients with primary hyperlipidaemia to investigate the effect of suloctidil (200 mg 3-times daily) on serum cholesterol levels and other lipidaemic variables. The first study was a double-blind, crossover comparison of suloctidil and placebo in 23 , with suloctidil for periods of up to 1 year. As in the short-term trial, patients were maintained on a controlled diet. The results showed that suloctidil produced a statistically significant reduction in total serum cholesterol and serum triglycerides in the short-term and this reduction was maintained over the longer period of the second study. In addition, there was a concomitant and approximately

Intermittent claudication: Suloctidil v.s. placebo treatment.

Activation of platelets and of fibrinolysis by venous occlusion in healthy volunteers and influence of suloctidil in comparison with placebo. The effect of venous occlusion on blood fibrinolytic activity and platelet activation was studied in 10 normal human volunteers. The procedure was used as a model to study the pharmacological effects of 1-(4-isopropylthiophenyl)-2-n-octylaminopropanol (suloctidil, Sulocton) in a double-blind cross-over trial comparing suloctidil 200 mg three times per day versus identical placebo, each given for one week at random, after an initial one-week placebo run-in; blood sampling was done at the end of each period. Statistically significant changes in plasminogen, alpha 2-anti-plasmin, fibrinogen and antithrombin-III were consistently obtained on each occasion

A double-blind trial of suloctidil v. placebo in intermittent claudication. In a recent double-blind trial lasting over 6 months, 40 patients suffering from intermittent claudication were randomly allocated to receive 300 mg of suloctidil per day or exactly matching placebo capsules. In addition to treadmill walking distance, other objective criteria including ankle blood pressure response and muscle blood flow measured by 133Xe clearance were used to assess the effectiveness of therapy. Nine patients (4 in the suloctidil group and 5 controls) did not complete the trial according to the protocol. Of the remaining 31 patients, 17 were in the control group and 14 received suloctidil. A significant improvement in the absolute walking distance, the level of beta-thromboglobulin (beta TG

Effects of suloctidil on platelet survival time following cardiac valve replacement. Platelet functions and blood clotting parameters were examined in 23 patients with a shortened platelet survival time after cardiac valve replacement. Treatment was given at random: for a first group antivitamin K with suloctidil and for the second group antivitamin K alone. Six weeks of treatment with antivitamin K alone did not induce any significant change in the platelet survival time, platelet retention or platelet factor 4 in plasma. In contrast, the shortened platelet survival time increased significantly after 6 weeks of treatment with suloctidil. Moreover the platelet retention and the amount of platelet factor 4 in plasma were significantly reduced, indicating that normalization of platelet