"Sultiame"

Others CA inhibitors * Sulfonamides: Acetazolamide * Ethoxzolamide * Sultiame

drugs. The original antibacterial sulfonamides are synthetic (nonantibiotic) antimicrobial agents that contain the sulfonamide group. Some sulfonamides are also devoid of antibacterial activity, e.g., the anticonvulsant sultiame. The sulfonylureas and thiazide diuretics are newer drug groups based upon the antibacterial sulfonamides.[1][2]Allergies to sulfonamides are common. The overall incidence Others CA inhibitors * Sulfonamides: Acetazolamide * Ethoxzolamide * Sultiame

Others CA inhibitors * Sulfonamides: Acetazolamide * Ethoxzolamide * Sultiame

Others CA inhibitors * Sulfonamides: Acetazolamide * Ethoxzolamide * Sultiame

Others CA inhibitors * Sulfonamides: Acetazolamide * Ethoxzolamide * Sultiame

of the condition and the low seizure frequency, treatment is often unnecessary. If treatment is warranted or preferred by the child and his or her family, antiepileptic drugs can usually control the seizures easily.[2] Carbamazepine is the most frequently used first-line drug, but many other antiepileptic drugs, including valproate, phenytoin, gabapentin, levetiracetam and sultiame have been found effective

currently under development. The clinical tolerability to single doses of sulthiame will also be closely monitored to orient future trials.Condition or disease Intervention/treatment Phase Epilepsy Drug: Sulthiame Phase 1 Detailed Description: Sulthiame (or sultiame), marketed in the 60's in Germany, Austria, Switzerland, Israel, Australia and Japan under the brand Outcome Measures Go to Top of Page Study Description Study Design Arms and Interventions Outcome Measures Eligibility Criteria Contacts and Locations More Information Primary Outcome Measures : 1. Elimination half-life of sultiame after single doses of 50, 100 and 200 mg of sulthiame in 4 healthy volunteers. [ Time Frame: 9 weeks ]Sultiame plasma concentration will be measured at predefined times after

: pregabaline Biological: sultiame Biological: tiagabine Biological: vigabatrine Biological: mesuximide Biological: primidone Biological: perampanel Biological: ethosuximide Biological: zonisamide Biological: cannabidiol Other: genetic polymorphisms Detailed Description: Epilepsy affects about 1% of the population, with a peak incidence in childhood, and persistent seizures on antiepileptic therapy in this population.The main goal is to develop population pharmacokinetic models for the following antiepileptic drugs in children: valproic acid, carbamazepine, phenobarbital, phenytoin, levetiracetam, lamotrigine, topiramate, oxcarbazepine, stiripentol, clobazam, brivaracétam, felbamate, lacosamide, rufinamide, gabapentine, pregabaline, sultiame, tiagabine, vigabatrine, mesuximide, primidone, perampanel