A case report of hypersomnia in tetrasomyX improved with medical therapy TetrasomyX is a rare chromosomal anomaly in which sleep disorders have not been previously reported. We report on one patient with tetrasomyX and hypersomnia successfully treated with psychostimulant therapy. Sleep disorders are rarely reported in chromosomal anomalies. Clinicians should screen patients for sleep
. In addition, we reviewed reports concerning the possible association between SLE and other connective tissue diseases and male polysomy-X. An 11-year-old girl with tetrasomy-X (48 XXXX karyotype) presented with prolonged fever. Workup led to the diagnosis of SLE, and subsequent renal biopsy revealed mild diffuse mesangial proliferative glomerulonephritis. Two additional cases of SLE in women with 47 XXX
, tetrasomyX, pentasomy X, and Turner syndrome mosaicism (see these terms).Antenatal diagnosisPatients diagnosed in the prenatal period should be followed closely for developmental delay so that early intervention therapies can be implemented as needed.Genetic counselingGenetic counseling is recommended, with families being informed about the sporadic nature of the chromosome anomaly, the wide variability