)D2BedaquilineDelamamidBdqDlmD3p-aminosalicylic acidImipenem-cilastatinMeropenemAmoxicillin-clavulanate(Thioacetazone2)PASIpmMpmAmx-Clv(T)1 Streptomycin can substitute other injectable drugs if none of these agents can be used and if the strain is shown not to be resistant. 2 Thioacetazone should not be used if the patient is HIV seropositive.10Standards for addressing HIV infection and comorbiditiesStandard 14 HIV counselling
: ethionamide; protionamide; cycloserine; terizidone; para-aminosalicylic acid Group 5 – Agents with unclear efficacy: clofazimine; linezolid; amoxicillin/clavulanate; thioacetazone; clarithromycin; imipenem/cilastatin; high-dose isoniazid. The revised guidelines (2011)4 state that streptomycin is considered as a first line agent and its use in MDR-TB patients is not recommended. In Group 4 products, among
(26/33), sulfamethoxazole (26/33), and tigecycline (25/33) showed the highest activity; clofazimine (20/33) and doxycycline (18/33) showed intermediate activity; and rifapentine (13/33), rifabutin (13/33), and minocycline (11/33) showed low antimicrobial activity, closely followed by thioacetazone (10/33) and pasiniazid (10/33), against the tested organisms. According to their susceptibility
tyrosinase inhibitors, we studied other thiourea-containing drugs as potential tyrosinase inhibitors. The thiourea-containing drugs in clinical use were retrieved and tested for their ability to inhibit tyrosinase. We observed that methimazole, thiouracil, methylthiouracil, propylthiouracil, ambazone, and thioacetazone inhibited mushroom tyrosinase. Except for methimazole, there was limited information regarding the activity of other drugs against tyrosinase. Both thioacetazone and ambazone significantly inhibited tyrosinase, with IC50 of 14 and 15 μM, respectively. Ambazone decreased melanin content without causing cellular toxicity at 20 μM in B16F10 cells. The activity of ambazone was stronger than that of kojic acid both in enzyme and melanin content assays. Kinetics of enzyme inhibition assigned
Conteben Thioacetazone - WikipediaThioacetazoneFrom Wikipedia, the free encyclopedia(Redirected from Conteben)Jump to navigationJump to search NY(what is this?)(verify) Thioacetazone (INN, BAN), also known as amithiozone (USAN), is an oral antibiotic which is used in the treatment
A second international cooperative investigation into thioacetazone side effects: 2. Frequency and geographical distribution of side effects As part of a large-scale international cooperative investigation into the side effects of thioacetazone-containing regimens in the treatment of tuberculosis, an evaluation has been made of the variation in the frequency of side effects between different treatment, the variation being similar for the two thioacetazone-containing regimens and for the streptomycin plus isoniazid control regimen, though at a lower level for the latter. In Malaysia, Singapore, and Trinidad, where different racial groups were under treatment, there was no clear indication that race was an important factor in explaining the differences between countries, except for cutaneous
A second international co-operative investigation into thioacetazone side-effects: 1. The influence of a vitamin and antihistamine supplement As part of a large-scale international, co-operative investigation into the side-effects produced by thioacetazone employed in the treatment of tuberculosis, an evaluation has been made of a supplement incorporating vitamins and an antihistamine was however infrequent, was reduced.In view of this lack of appreciable benefit, as well as the higher cost and impaired keeping properties of tablets containing thioacetazone plus isoniazid when the supplement is added, the use of the supplement as a prophylactic cannot be recommended.
, isoniazid and thioacetazone (SHT). All the cases were hospitalized. A significant rise in serum uric acid levels was found in 66% of SHE patients during the first 60-90 days of treatment, but there was no such change in the SHT patients. In one patient who received ethambutol generalized arthralgia developed and in another acute gouty arthritis was observed. In both cases, symptoms abated when ethambutol
drugs (WHO group 5) include drugs that may be useful, but have doubtful or unproven efficacy: * rifabutin * macrolides: e.g., clarithromycin (CLR); * linezolid (LZD); * thioacetazone (T); * thioridazine; * arginine; * vitamin D; * bedaquiline.These drugs are listed here either because they are not very effective (e.g., clarithromycin) or because their efficacy has not been proven (e.g., linezolid and protease inhibitors have an increased risk of treatment failure or relapse.[69]The World Health Organization (WHO) warns against using thioacetazone in patients with HIV, because of the 23% risk of potentially fatal exfoliative dermatitis.[70][71]According to Caprisa 003 (SAPiT) Study the mortality in patients who were started on anti-retrovirals during TB treatment was 56% lower than those started after