The molecular pathogenesis of Trichilemmalcarcinoma. Trichilemmalcarcinoma (TC) is an extremely rare hair follicle tumor. We aimed to explore the genetic abnormalities involved in TC to gain insight into its molecular pathogenesis. Data from patients diagnosed with TC within a 12-year period were retrospectively reviewed. Genomic DNA isolated from a formalin-fixed paraffin-embedded (FFPE
Malignant tumor of outer root sheath epithelium, trichilemmalcarcinoma: Clinical presentations, treatments and outcomes To emphasize different clinical features of tumor that can be misdiagnosed clinically. A total of 8 cases operated between September 2009 and 2016 at the Celal Bayar University, Faculty of Medicine were included in the study. Patients' clinicopathological features, type
Eyelid trichilemmalcarcinomaTrichilemmalcarcinomas are rare malignant adnexal tumors which can involve the head and, rarely, the eyelid. Accurate diagnosis and differentiation from basal cell carcinoma or trichoepithelioma are dependent on histopathological and immunohistochemical analysis. We report a case of an eyelid mass, initially diagnosed by incisional biopsy as a trichoepithelioma , later found on excisional biopsy to be a trichilemmalcarcinoma and present a review of the literature of the histopathology, differential diagnosis and management. Consideration of these entities will be useful to the histopathologist and clinician to better identify and treat these challenging lesions.
TrichilemmalCarcinoma from Proliferating Trichilemmal Cyst on the Posterior Neck Trichilemmal cysts are common fluid-filled growths that arise from the isthmus of the hair follicle. They can form rapidly multiplying trichilemmal tumors-, also called proliferating trichilemmal cysts, which are typically benign. Rarely, proliferating trichilemmal cysts can become cancerous. Here we report the case . The tumor was removed without safety margin, and the skin defect was covered with a split-thickness skin graft. The pathologic diagnosis was a benign proliferating trichilemmal cyst. The mass recurred after 4months, at which point, a wide excision (1.3-cm safety margin) and split-thickness skin graft were performed. The biopsy revealed a trichilemmalcarcinoma arising from a proliferating trichilemmal
Mohs micrographic surgery versus wide local excision for treatment of trichilemmalcarcinoma: a systematic review PROSPERO International prospective register of systematic reviews Print | PDF PROSPERO This information has been provided by the named contact for this review. CRD has accepted this information in good faith and registered the review in PROSPERO. The registrant confirms
Metastatic trichilemmalcarcinoma in a patient with breast cancer Trichilemmalcarcinoma (TC) is described as a very rare cancer of the skin adnexa. Ninety per cent of the lesions present on the scalp. Prognostic factors in TC are limited to lymph node status and surgical margins, with no statistical significance observed for age or gender of the patient, size of tumour or locoregional
Management of trichilemmalcarcinoma: an update and comprehensive review of the literature. Trichilemmalcarcinoma (TC) is a rare malignant adnexal neoplasm with outer root sheath differentiation. Most cases have been treated by surgical excision with a few recurrences. There have been 6 case reports of TC treated with Mohs micrographic surgery (MMS). To perform an updated review of the literature regarding management of this uncommon tumor. A comprehensive literature review was conducted by searching the PubMed database using the keywords trichilemmalcarcinoma, tricholemmal carcinoma, and tricholemmocarcinoma. There have been 103 reported cases of TC, and most of these were treated with surgical excisions. Of the 35 cases with follow-up data, 3 reported local recurrences and 1 had
in pediatric XP patients. Our literature search yielded 130 pediatric XP patients with oral involvement and 210 associated tumoral or non-tumoral lesions. Squamous cell carcinoma was the most common type of oral mucosal tumor reported, with other malignancies including basal cell carcinoma, melanoma, angiosarcoma, fibrosarcoma, and trichilemmalcarcinoma. Given the potential morbidity and mortality
man with a scalp lesion; on biopsy, the morphology and immunoprofile suggested MCC with divergent squamous differentiation. Patient 2 was an 87-year-old woman with a lesion on her leg, originally reported as squamous cell carcinoma, later showing extensive local recurrence. On review, primary histology showed an MCC with divergent differentiation, most likely trichilemmalcarcinoma; the recurrence
(trichilemmalcarcinoma). Because of the discrepancy between clinical and histopathological findings, the tumor specimen was submitted to another facility, wherein lymphoma infiltration by anaplastic large cells was found in the dermis and subcutaneous tissue. C-ALCL. The patient was transferred to the Lymphoid Tumours Clinic of the Maria Skłodowska Curie Memorial Cancer Centre and Institute of Oncology
of trichilemmalcarcinoma or hidradenocarcinoma have not been reported. Two (4.2%) regional lymph node metastases but no distant metastases or local recurrences have been reported in eccrine porocarcinoma. Squamoid eccrine duct tumor, pilomatrix carcinoma, and spiradenocarcinoma treated with MMS are also reviewed. The rarity of ACs and the lack of comparative data on treatment makes conclusive recommendations
sweat duct carcinoma (n=1), mucinous carcinoma (n=1), ductal eccrine adenocarcinoma (n=1), porocarcinoma (n=1), and trichilemmalcarcinoma (n=1). All tumors were reviewed by a dermatopathologist to confirm the SAC diagnosis.All patients had undergone surgery. Indications for adjuvant radiation included involved lymph nodes (n=4), perineural invasion (n=2), nodal extracapsular extension (n=2), positive
, and a 53-year-old man from Khyber Pakhtunkhwa. The male to female ratio was 1.2:1. The histological variations were sebaceous differentiation (n = 4), microcystic adnexal carcinoma (n = 4), trichilemmalcarcinoma (n = 1), pilomatrix carcinoma (n = 1), and hidradenocarcinoma (n = 1). The mean age at presentation was 54 years (range 32 to 75). The primary subsite of involvement was the scalp in nine
are small, resembling a syringoma; however, they contain keratin instead of eccrine secretion. Also notice the characteristic markedly fibrous stroma. * * High-powered view of desmoplastic trichoepithelioma. Notice the cluster of squamous cells surrounding a small cystic area containing keratin. Intervening stroma is markedly fibrous. * * The malignant counterpart, trichilemmalcarcinoma, typically shows areas with infiltrative growth and necrosis. * * Trichilemmalcarcinoma cells have large, lightly stained cytoplasm with large, pleomorphic nuclei. As a sign of follicular differentiation, some cells may display the characteristic cytoplasmic, red, trichohyalin granules (arrows). of 10 TablesBack to List Contributor Information and Disclosures Author Victor G Prieto, MD, PhDFerenc and Phyllis
-Oct. 30 (5):491-4. [QxMD MEDLINE Link]. 26. Kanoh M, Amoh Y, Sato Y, Katsuoka K. Expression of the hair stem cell-specific marker nestin in epidermal and follicular tumors. Eur J Dermatol. 2008 Sep-Oct. 18(5):518-23. [QxMD MEDLINE Link]. 27. Kurokawa I, Senba Y, Nishimura K, Habe K, Hakamada A, Isoda K. Cytokeratin expression in trichilemmalcarcinoma suggests differentiation
stroma is markedly fibrous. * * The malignant counterpart, trichilemmalcarcinoma, typically shows areas with infiltrative growth and necrosis. * * Trichilemmalcarcinoma cells have large, lightly stained cytoplasm with large, pleomorphic nuclei. As a sign of follicular differentiation, some cells may display the characteristic cytoplasmic, red, trichohyalin granules (arrows). of 10 TablesBack
M, Amoh Y, Sato Y, Katsuoka K. Expression of the hair stem cell-specific marker nestin in epidermal and follicular tumors. Eur J Dermatol. 2008 Sep-Oct. 18(5):518-23. [QxMD MEDLINE Link]. 27. Kurokawa I, Senba Y, Nishimura K, Habe K, Hakamada A, Isoda K. Cytokeratin expression in trichilemmalcarcinoma suggests differentiation towards follicular infundibulum. In Vivo. 2006 Sep-Oct. 20(5
are small, resembling a syringoma; however, they contain keratin instead of eccrine secretion. Also notice the characteristic markedly fibrous stroma. * * High-powered view of desmoplastic trichoepithelioma. Notice the cluster of squamous cells surrounding a small cystic area containing keratin. Intervening stroma is markedly fibrous. * * The malignant counterpart, trichilemmalcarcinoma, typically shows areas with infiltrative growth and necrosis. * * Trichilemmalcarcinoma cells have large, lightly stained cytoplasm with large, pleomorphic nuclei. As a sign of follicular differentiation, some cells may display the characteristic cytoplasmic, red, trichohyalin granules (arrows). of 10 TablesBack to List Contributor Information and Disclosures Author Victor G Prieto, MD, PhDFerenc and Phyllis