Molecular evidence of Tulavirus in Microtus obscurus in the region of Yili, Xinjiang, China. Hantaviruses are important zoonotic pathogens, and they pose a profound risk to public health. So far, there has been no evidence showing that Tulavirus (TULV), one species of hantavirus, is endemic in China. In this study, we captured rodents and found that the Tulavirus had infected voles in Yili gene confirmed that all of the detected amplicons were TULV, which was similar to one strain of TULV identified in Kazakhstan. This is the first identification of Tulavirus in China, and we found that M. obscurus acts as a natural reservoir for carrying the virus. Although the infection rate in the local human population remains unknown, the high prevalence of TULV in the small mammals in the region
to be hospitalised in North Wales, Yorkshire, Humberside and Scotland.Studies of rodents trapped in Cheshire, showed the existence of a novel Hantavirus, which is related to PUUV and Tulavirus (TULV).PathogenesisHantavirus is named after the Hantaan River in Korea. Hantaviruses are Bunyaviruses usually classified with the viral haemorrhagic fevers (VHFs[4] .Hantaviruses infect endothelial cells.In HFRS the cells
Tula hantavirus infection in a hospitalised patient, France, June 2015. We report an infection with Tulavirus in June 2015, leading to hospitalisation, in a patient living approximately 60 km east of Paris with no previous remarkable medical history. Clinical symptoms were limited to a fever syndrome with severe headache. The main laboratory findings included thrombocytopenia and elevated
the occurrence of viruses (including Tulavirus, Puumala virus, and Dobrava-Belgrade virus) among rodents. We examined 70 suspected human cases with symptoms corresponding to the clinical picture of HFRS. Serological analysis (indirect immunofluorescence assay and immunoblot) confirmed the presence of anti-hantavirus antibodies in 18 patients, which were surveyed with regard to developed symptoms and presumed
Tula hantavirus infection in immunocompromised host, czech republic. We report molecular evidence of Tula hantavirus as an etiologic agent of pulmonary-renal syndrome in an immunocompromised patient. Acute hantavirus infection was confirmed by using serologic and molecular methods. Sequencing revealed Tulavirus genome RNA in the patient's blood. This case shows that Tulavirus can cause serious
by the commonly used reverse transcription (RT)-PCR is difficult because of high sequence diversity of hantaviruses and low viral loads in clinical specimens. We developed 5 real-time RT-PCR assays, 3 of which are specific for the individual European hantaviruses Dobrava, Puumala, or Tulavirus. Two additional assays detect the Asian species Hantaan virus together with Seoul virus and the American species Andes
observed that the Tulavirus-induced cell death process is augmented by external TNF-alpha. Since TNF-alpha is involved in the pathogenesis of hantavirus-caused hemorrhagic fever with renal syndrome (HFRS) we investigated its effects on HFRS-causing hantavirus-infected cells. We studied both apathogenic (Tula and Topografov) and pathogenic (Puumala and Seoul) hantaviruses for their ability to regulate
by recombination between viruses from two genetic lineages. Here we show transfection-mediated rescue of Tulavirus carrying recombinant S RNA segment. Independent attempts yielded S RNA molecules of similar structure; the majority of them carried a break point located close to one of the break points suggested for natural recombinants. Recombinant virus purified from the original variant was able to grow