Optilume for anterior urethralstrictures Optilume for anterior urethralstrictures Medtech innovation briefing Published: 5 January 2021 www.nice.org.uk/guidance/mib241 pathwaysSummary Summary • The technologytechnology described in this briefing is Optilume. It is used to treat anterior urethralstrictures that need treating again because they have re-occurred after first-line endoscopic treatment. • The innovative aspectsinnovative aspects are that it incorporates balloon dilation with an anti-proliferative drug called paclitaxel, which is delivered around the inside surface of the urethra during the procedure. • The intended place in therapyplace in therapy would be as an alternative to standard care for urethralstrictures. • The main points from the evidencemain points from
Drug-coated balloon dilation catheter for the transurethral treatment of urethralstrictures - Assessment according to §137h Social Code Book V 1 Translation of the executive summary of the §137h assessment: H20-02 Medikamentenbeschichteter Ballondilatationskatheter zur transurethralen Behandlung von Harnröhrenstrikturen (Version 1.1; Status Drug-coated balloon catheter for urethralstrictures 12 February 2021 Institute for Quality and Efficiency in Health Care (IQWiG) - 1 - Publishing details Publisher Institute for Quality and Efficiency in Health Care Topic Drug-coated balloon catheter for the transurethral treatment of urethralstrictures Commissioning agency Federal Joint Committee Commission awarded on 16 December 2020 Internal
Drug-coated balloon catheter for the transurethral treatment of urethralstrictures - Second addendum to commission H20-02 1 Translation of the executive summary of the addendum H21-11 Medikamentenbeschichteter Ballondilatationskatheter zur transurethralen Behandlung von Harnröhrenstrikturen – 2. Addendum zum Auftrag H20-02 (Version 1.0; Status: 30 August 2021). Please note : This translation is provided as a service by IQWiG to English-language readers. However, solely the German original text is absolutely authoritative and legally binding. Extract IQWiG Reports – Commission No. H21-11 Drug-coated balloon catheter for the transurethral treatment of urethralstrictures 2. Addendum to Commission H20-021 Extract of addendum H21-11 Version 1.0 Drug-coated balloon catheter for urethral
Open urethroplasty versus endoscopic urethrotomy for recurrent urethralstricture in men: the OPEN RCT Open urethroplasty versus endoscopic urethrotomy for recurrent urethralstricture in men: the OPEN RCT * Text only * * Home * Journals * * Other NIHR research * * For authors * For reviewers * About * * Accessibility * Journals LibraryNHS NIHR - National Institute for Health Research Select
Urethral-sparing laparoscopic simple prostatectomy for the treatment of benign prostatic hyperplasia with asymptomatic urethralstricture after urethralstricture surgery. To evaluate the efficacy of urethral-sparing laparoscopic simple prostatectomy (US-LSP) for the treatment of large-volume (>80 ml) benign prostatic hyperplasia (BPH) with asymptomatic urethralstricture (urethral lumen > 16 Fr ) after urethralstricture surgery. We retrospectively analyzed clinical data of 39 large-volume BPH patients with asymptomatic urethralstricture after urethralstricture surgery who underwent US-LSP from January 2016 to October 2021. Postoperative follow-ups were scheduled at 1, 3, and 6 months. All patients affected by significant BPH-related lower urinary tract symptoms (LUTS) including 22 cases
Construction of a nomogram to predict urethralstricture after transurethral resection of the prostate: A retrospective cohort study. To investigate the risk factors for urethralstricture (US) in patients with benign prostatic hyperplasia (BPH) after transurethral resection of the prostate (TURP) and to construct a nomogram model with predictive features. Clinical data of 400 patients with BPH
Outcomes of Urethroplasty for Synchronous Anterior UrethralStricture Utilizing the Trauma and Urologic Reconstruction Network of Surgeons (TURNS) Length, Segment and Etiology Anterior UrethralStricture Classification System. To describe the characteristics, management, and functional outcomes of patients with synchronous urethralstricture disease (SUSD) utilizing a multi-institutional cohort . Data were collected and assessed from a prospectively maintained, multi-institutional database. Patients who underwent anterior urethroplasty for USD were included and stratified by the presence or absence of SUSD. USD location and etiology were classified according to the TURNS LSE Anterior UrethralStricture Classification System. Anterior urethroplasty techniques were recorded for both strictures
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UrethralStricture Symptom and Impact Measure (USSIM) Validation Study. To create and validate a disease-specific Patient-Reported Outcome Measure (PROM) derived from the patient voice for men with a urethralstricture disease. We previously performed and published a qualitative assessments to construct a disease-specific PROM for urethralstricture disease. Psychometric evaluations were done to discriminate patients who did better or worse following surgery. The intraclass correlation coefficient for USSIM score was 0.74 indicating moderate to good test-retest reliability. The UrethralStricture Symptom and Impact Measure possesses strong measurement properties that are representative for use in men with a urethralstricture. We propose use of this instrument in the preoperative and postoperative
Multi-Institutional Analysis of Surgery for Lichen Sclerosus Induced Penile UrethralStricture: Establishing Single-Stage Urethroplasty as a Primary Treatment Option. Ideal treatment of lichen sclerosus (LS) induced penile urethralstrictures (PUS) remains elusive. The objective of this study is to compare multi-institutional outcomes of single-stage urethroplasty (SSU) with oral mucosal graft
Comparative Efficacy of Dorsal-Onlay and Ventral-1 Inlay Buccal Mucosal Graft Urethroplasty in Female UrethralStricture: A Randomized Clinical Trial. To compare the outcomes of dorsal-onlay (DO) and ventral‑inlay (VI) buccal mucosal graft urethroplasty (BMGU). This is the first Clinical Trials Registry-India registered randomized clinical trial on female urethralstricture disease. Women
Extracellular matrix analysis of fibrosis: A step towards tissue engineering for urethralstricture disease. The urogenital tract is a target for many congenital and acquired diseases, both benign and oncogenic. In males, the urethra that transports urine and semen can be obstructed by a fibrotic disease called urethralstricture disease (USD). In severe USD, the whole organ including
Evaluating Tools for Characterizing Anterior UrethralStricture Disease: A Comparison of the LSE System and the UrethralStricture Score. We evaluated if scores generated by the LSE classification system and the UrethralStricture Score system are associated with intraoperative surgical complexity and stricture recurrence risk. We retrospectively reviewed all consenting patients who underwent single-stage anterior urethroplasty by a single surgeon at 2 institutions. UrethralStricture Score and a numerical LSE "score" was calculated for each patient. Pearson's correlation and linear regression analyses were used to assess for a relationship between increasing UrethralStricture Score and LSE score and surgical complexity. Kaplan-Meier curves and Cox proportional hazard regression models
Deep Phenotyping the Anterior UrethralStricture: Characterizing the Relationship Between Inflammation, Fibrosis, Patient History and Disease Pathophysiology. Anterior urethralstricture disease (aUSD) is a complex, heterogeneous condition which is idiopathic in origin for most men. This gap in knowledge rarely affects the current management strategy for aUSD, as urethroplasty does not generally for intervention would emerge based on stricture presence/absence, stricture etiology, and the presence/absence of stricture inflammation. Men with aUSD undergoing urethroplasty were recruited from one of five participating centers. Enrollees provided urethralstricture tissue and blood/serum on the day of surgery and completed patient reported outcome measure questionnaires both pre and post-operatively
Outcomes of Ventral Onlay Buccal Mucosal Graft Urethroplasty In Bulbomembranous urethralstrictures Post-Transurethral Resection of the Prostate. To evaluate the outcomes of Ventral Onlay Buccal Mucosal Graft Urethroplasty (VOBMGU) in bulbomembranous urethralstrictures after transurethral resection of the prostate (TURP). After approval of the institutional ethical committee, we retrospectively
Impact of a clinical care pathway developed through the action research method on the psychological well-being and quality of life in male patients with urethralstricture. The objective of this study is to examine the development of a clinical care pathway utilizing an action research methodology for male patients with urethralstricture, and to assess the psychological and quality of life outcomes following the implementation of this pathway. Ninety patients diagnosed with urethralstricture, admitted to our hospital between May 2021 and May 2022, were selected as the study cohort. Employing a random number method, these patients were allocated into an observation group and a control group, each comprising 45 individuals. The control cohort employs standard care protocols for individuals