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Trial protocol for a multicenter randomized controlled trial to assess the efficacy and safety of intravenous ketamine for chronicdailyheadaches: the "KetHead" trial. Chronicdailyheadaches (CDH) are common and associated with significant morbidity, poor quality of life, and substantial burden on the healthcare system. CDH tends to be refractory to conventional medical management
Associations between Plasma Lipid Mediators and ChronicDailyHeadache Outcomes in Patients Randomized to a Low Linoleic Acid Diet with or without Added Omega-3 Fatty Acids. A previous report showed that 12-week lowering of dietary omega-6 linoleic acid (LA) coupled with increased omega-3 polyunsaturated fatty acid (PUFA) intake (H3-L6 diet) reduced headache frequency and improved quality of life in patients with chronicdailyheadaches (CDHs) compared to dietary LA reduction alone (L6 diet). The trial also showed that targeted dietary manipulation alters PUFA-derived lipid mediators and endocannabinoids. However, several additional classes of lipid mediators associated with pain in preclinical models were not measured. The current secondary analysis investigated whether the clinical
Association between iron deficiency anemia and chronicdailyheadache: A case-control study. We aimed to determine the association between iron deficiency anemia and chronicdailyheadache. This case-control study was conducted in a tertiary care center in Dehradun, India. One hundred patients with chronicdailyheadache were randomly selected for the study with an equal number of controls . Subsets of chronicdailyheadache were diagnosed as per the 3rd edition of the International Classification of Headache Disorders. The study participants were assessed for iron deficiency anemia. The mean age of the patients was 51.1 ± 22.1 years. Male: female ratio was 1:1.08. Chronic migraine was present in 62 (62%), tension-type headache in 23 (23%), and new daily persistent headache in 15 (15
Phenotype of new daily persistent headache: subtypes and comparison to transformed chronicdailyheadache. It is unknown whether new daily persistent headache (NDPH) is a single disorder or heterogenous group of disorders, and whether it is a unique disorder from chronic migraine and chronic tension-type headache. We describe a large group of patients with primary NDPH, compare its phenotype to transformed chronicdailyheadache (T-CDH), and use cluster analysis to reveal potential sub-phenotypes in the NDPH group. We performed a case-control study using prospectively collected clinical data in patients with primary NDPH and T-CDH (encompassing chronic migraine and chronic tension-type headache). We used logistic regression with propensity score matching to compare demographics, phenotype
CGRP antibody therapy in patients with drug resistant migraine and chronicdailyheadache: a real-world experience. Calcitonin gene-related peptide (CGRP) (receptor) antibodies (erenumab, fremanezumab and galcanezumab) are increasingly used in prophylactic treatment of migraine. In the approval studies, severely affected patients with migraine and chronicdailyheadache without any headache free , migraine duration and intensity improved under therapy. Despite the low responder rate, CGRP antibodies can be effective at least in a few cases of severely affected patients with drug resistant migraine and chronicdailyheadache. Retrospective registered.
Validity and Reliability of the Fibromyalgia Rapid Screening Tool Among Individuals with ChronicDailyHeadache: A Clinic-Based Study. Fibromyalgia is a common chronic pain disorder typically associated with headache disorders, particularly chronicdailyheadache. However, fibromyalgia is typically underdiagnosed and undertreated. The Fibromyalgia Rapid Screening Tool questionnaire is a brief headache. Consecutive first-visit headache patients with primary chronicdailyheadache (≥15 days/month for three or more months) at the outpatient clinics of four university hospitals were enrolled in this study from April 2015 to October 2015, and the validity and reliability of the Fibromyalgia Rapid Screening Tool questionnaire for determining fibromyalgia were evaluated. Fibromyalgia was diagnosed
Multidisciplinary Team Treatment Approaches to ChronicDailyHeadaches. In this review, we focus on nonmedication treatment approaches to chronicdailyheadaches and chronic migraine. We review the current scientific data on studies using multimodal treatments, especially physical therapy and occupational therapy, and provide recommendations on the formation of interdisciplinary headache teams . Chronicdailyheadache, which includes chronic migraine, is a particularly challenging clinical entity which often involves multiple headache types and comorbidities. A team approach in treating these patients may be particularly useful. We review all current studies performed with at least one or more other modality in addition to usual medical treatment, with a focus on physical and occupational
Psychiatric Comorbidities and Environmental Triggers in Patients with ChronicDailyHeadache: A Lifestyle Study Patients with chronicdailyheadache (CDH) suffer from several significant psychiatric comorbidities and have unhealthy lifestyle. We aimed at studying psychiatric comorbidities, environmental triggers, lifestyle factors, and intensity of CDH in patients referred by the department
Management of ChronicDailyHeadache and Psychiatric Co-Morbidities by Lifestyle Modification: Participatory Action Research Combining New Communication Media Lifestyle modification has a significant role in chronicdailyheadache (CDH) management. Participatory action research (PAR) can play an important role in managing chronic medical conditions. However, it has been scarcely used in CDH
ChronicDailyHeadache: Ten Steps for Primary Care Providers to Regain Control. Chronicdailyheadache (CDH) affects 2% to 4% of the North American and European population. Various pathways lead to this condition, although chronification of migraine and the occurrence of central sensitization in tension headache are the 2 most common. Medication overuse headaches complicate a substantial portion
ChronicDailyHeadache and Medication Overuse Headache in First-Visit Headache Patients in Korea: A Multicenter Clinic-Based Study Chronicdailyheadache (CDH) is defined as a headache disorder in which headaches occur on a daily or near-daily basis (at least 15 days/month) for more than 3 months. Chronic migraine (CM) and medication overuse headache (MOH) are very disabling headaches
Allergic Rhinitis and ChronicDailyHeadaches: Is There a Link? Allergic rhinitis and migraine remain on the list of the most common diseases affecting adults. Migraines and headaches due to allergic rhinitis are easily confused because the symptoms of both conditions often overlap. Both may occur with sinus headache, nasal congestion, and lacrimation and may worsen with weather changes
Study of Sleep Disorders and Polysomnographic Evaluation among Primary ChronicDailyHeadache Patients Studies related to sleep disorders and polysomnography (PSG) among chronicdailyheadache patients are rare. We studied this and compared chronic migraine (CM) with chronic tension-type headache. Eighty-three patients were recruited. They were evaluated by semi-structured interview, headache
A neurometabolite study of chronicdailyheadache in patients with systemic lupus erythematosus using magnetic resonance spectroscopy: comparison with fibromyalgia patients and healthy controls Neuropsychiatric systemic lupus erythematosus (SLE) includes a broad spectrum of neurologic and psychiatric manifestations. One of the most commonly observed neuropsychiatric symptoms is headache. However , the lack of specific clinical distinctions for headache in SLE has made it difficult to elucidate its pathophysiology. The aim of this study is to evaluate the neurometabolic changes using Proton Magnetic Resonance Spectroscopy (H-MRS) in patients with SLE who suffer from chronicdailyheadache (CDH). SLE and fibromyalgia patients with CDH and healthy controls were recruited (n = 9, n = 5, and n = 6
A Multicenter, Double-Blind, Randomized, Placebo-Controlled Trial to Evaluate the Efficacy and Safety of Duliang Soft Capsule in Patients with ChronicDailyHeadache. Objective. To investigate the efficacy and safety of traditional Chinese medicine Duliang soft capsule (DSC) in prophylactic treatment for patients with chronicdailyheadache (CDH). Methods. A multicenter, double-blind, randomized
A Flexible Format Interdisciplinary Treatment and Rehabilitation Program for ChronicDailyHeadache: Patient Clinical Features, Resource Utilization and Outcomes. To describe the demographics, diagnoses, program duration, human resource utilization and outcomes of patients with chronicdailyheadache treated in an ambulatory, interdisciplinary, flexible format, treatment and rehabilitation program. Research indicates that multidisciplinary care is an effective approach to manage chronicdailyheadache, but little is known about the resources needed for effective care. The study was a secondary data analysis within a cohort design of previously collected data. Patients completed questionnaires and outcome measures on admission and discharge. Diagnoses were extracted from patient charts
Randomized Controlled Trial of the Acceptability, Feasibility, and Preliminary Effects of a Cognitive Behavioral Skills Building Intervention in Adolescents with ChronicDailyHeadaches: A Pilot Study. The treatment challenge of adolescents with chronicdailyheadaches (CDHs) creates an urgent need for evidence-based interventions. Therefore the purpose of this pilot study was to evaluate
The Positive Impact of Integrative Medicine in the Treatment of Recalcitrant ChronicdailyHeadache: A Series of Case Reports People who suffer from recalcitrant chronicdailyheadache (CDH)-a primary, episodic headache occurring at least 15 days per month, and lasting four or more hours per day for at least three consecutive months(1)-have generally tried many pain relief medications with few
Assessment of the Efficacy of the Transnasal Sphenopalatine Ganglion Block in the Treatment of ChronicDailyHeadache in Children and Adolescents. Primary Objective The primary objective of the study is to assess whether transnasal sphenopalatine ganglion block using the device TX360 reduces intensity and severity of the Post-Traumatic Headache in adolescents.Secondary ObjectivesThe study